CRBN
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Official Full Name
cereblon
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Overview
This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CRBN; cereblon; mental retardation, non syndromic, autosomal recessive, 2A , MRT2A; protein cereblon; 2900045O07Rik; AF229032; AW108261; piL; 2610203G15Rik; DKFZp781K0715; MGC27358; MRT2A; OTTHUMP00000209555; Protein x 0001; MRT2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- Avi
- Flag
- GST
- His (Fc)
- His|B2M
- His|Myc
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CRBN Related Research Area
CRBN involved in several pathways and played different roles in them. We selected most pathways CRBN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CRBN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
CRBN has several biochemical functions, for example, ATP-dependent peptidase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRBN itself. We selected most functions CRBN had, and list some proteins which have the same functions with CRBN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP-dependent peptidase activity | SPG7;CRBN;LONRF3;AFG3L2;LONP1;LONRF2;YME1L1;LONRF1L |
| metal ion binding | COL3A1;ZNF383;ISL2B;CSRP1A;GGTA1;CNDP2;FLYWCH1;ZBTB7A;NGLY1 |
| protein binding | OPRK1;INSIG1;RGS17;TUBA1A;RPTOR;MYO5A;MITD1;PPARA;FAM189B |
CRBN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRBN here. Most of them are supplied by our site. Hope this information will be useful for your research of CRBN.
PAK7; RBPMS; GTF2F2; IKZF1; Ddb1; COPS6; SUV39H1; KDM1A; ysuI; flaF; q8d015_yerpe
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