CRHR2
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Official Full Name
corticotropin releasing hormone receptor 2
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Overview
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
CRHR2; corticotropin releasing hormone receptor 2; corticotropin-releasing factor receptor 2; CRF RB; CRF2; HM CRF; Corticotropin-releasing hormone receptor 2; CRF 2; CRF 2R; CRF R2; CRF-R-2; CRF-R2; CRF2R; CRFR 2; CRFR-2; CRFR2; CRFR2_HUMAN; CRH 2R; CRH R2; CRH-R-2; CRH-R2; CRH2R; CRHR 2; CRF2 receptor, beta isoform; CRF-RB; HM-CRF;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Homo sapiens (Human)
- Human
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
CRHR2 involved in several pathways and played different roles in them. We selected most pathways CRHR2 participated on our site, such as Class B/2 (Secretin family receptors), Corticotropin-releasing hormone, G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRHR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class B/2 (Secretin family receptors) | CRH;CALCB;CD97;GCGB;PTHLHA;ADCYAP1B;CRHR2;ADM2;CRHR1 |
| Corticotropin-releasing hormone | CRHR2;TBX19;TFAP2A;KRT1;TCF4;ADRBK2;KRT14;TRIM28;CRHR1 |
| G alpha (s) signalling events | PTHLH;PTH2;ADM2;CRH;CRHB;INSL3;RLN2;RAMP1;PTH |
| GPCR downstream signaling | INSL5;TIAM2;TRPC7;GPR18;RGS4;RLN2;QRFP;CRH;APLNR |
| GPCR ligand binding | PTH2;NMBA;S1PR1;PENKA;GPR17;EMR4;INSL5;CCR9;LPAR2A |
| GPCRs, Class B Secretin-like | CALCRL;EMR2;CRHR2;ELTD1;LPHN1;ADCYAP1R1;CRHR1;EMR1;CD97 |
| Neuroactive ligand-receptor interaction | PTGER2A;P2RY1;CHRNA1;TRHR;GRIN2D;TAAR4;C3AR1;CHRNA7;CHRM5B |
| Signal Transduction | AATF;RSPO1;ACVR1C;NPFF;RDH7;FGFBP3;CXCL11.8;MDK;GPR65 |
CRHR2 has several biochemical functions, for example, corticotrophin-releasing factor receptor activity, corticotropin-releasing hormone receptor activity, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CRHR2 itself. We selected most functions CRHR2 had, and list some proteins which have the same functions with CRHR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| corticotrophin-releasing factor receptor activity | CRHR1;CRHR2 |
| corticotropin-releasing hormone receptor activity | CRHR2;CRHR1 |
| hormone activity | SST6;NMB;PRL7B1;IGF2A;HAMP;IGF3;PYY;CGA;CSHL1 |
| peptide hormone binding | NPR3;OXTR;MC4R;EDNRB;RXFP2;AGTR1B;NPR2;CRHR2;GIPR |
| protein binding | CLK4;TMEM173;SOX30;PPP2R1A;KNDC1;AP1M2;FOXH1;SNW1;RGL2 |
CRHR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRHR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CRHR2.
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