CRLF2
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Official Full Name
cytokine receptor-like factor 2
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Overview
The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CRLF2; cytokine receptor-like factor 2; CRL2; TSLPR; IL-XR; TSLP receptor; P2RY8/CRLF2 fusion; cytokine receptor-like 2; cytokine receptor CRL2 precusor; thymic stromal lymphopoietin receptor; thymic stromal lymphopoietin protein receptor; thymic stromal-;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- CHO cells
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- NS0
- Wheat Germ
- Fc
- Fc Chimera
- Avi
- Flag
- GST
- His
- His (Fc)
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CRLF2 Related Research Area
CRLF2 involved in several pathways and played different roles in them. We selected most pathways CRLF2 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRLF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | Il6ra;CD40LG;PRP2;IL2RGB;IL2RGA;ACVR2AA;CCL28;IL3;Ccl21a |
Jak-STAT signaling pathway | LEPR;CSH;PIK3R2;IL24;IL4R;MCL1;STAM;STAT1B;IL13RA2 |
CRLF2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CRLF2 itself. We selected most functions CRLF2 had, and list some proteins which have the same functions with CRLF2. You can find most of the proteins on our site.
Function | Related Protein |
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CRLF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRLF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CRLF2.
- Q&As
- Reviews
Q&As (6)
Ask a questionThe protein may interact with other proteins to fulfill its function. These interactions can involve various types of protein-protein interactions like electrostatic interactions, hydrogen bonding, etc. Understanding these interactions can help unravel the mechanism of action of the CRLF2 protein in cells.
The expression level of CRLF2 protein may be regulated by a variety of factors, including gene transcription, translation, post-transcriptional modification, etc. Studying these regulatory mechanisms can help to understand the expression patterns of CRLF2 protein in organisms and its impact on biological processes.
Mutations or modifications of the CRLF2 protein may affect its function and thus affect the organism. The specific effects may vary depending on the type and location of the mutation or modification and may involve various biological processes, such as growth and development, immune response, etc.
CRLF2 protein may be involved in a variety of biological processes, including immune response, regulation of hematopoietic processes, cell growth and differentiation, etc. These processes require the regulatory effect of CRLF2 protein for normal life activities.
Studying the structure and function of CRLF2 protein may require the design of a series of experiments, including biochemical and cell biology experiments. For example, X-ray crystal diffraction can be used to study its structure, and its function can be studied by gene knockout or knockdown techniques.
Evaluating the potential of CRLF2 protein as a drug target may involve several aspects, including its expression level in organisms, its role in biological processes, and its changes in disease. In addition, factors such as ease of drug development for this protein and potential drug side effects need to be considered. At the same time, in vitro and in vivo experiments can be performed with known CRLF2 inhibitors or agonists to verify their efficacy and safety.
Customer Reviews (3)
Write a reviewCRLF2 is highly expressed, which is convenient for detection and quantification.
Green and pollution-free, it can be seen that the manufacturer is very environmentally conscious.
The range of applications is breathtaking, and it can play an important role in any field.
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