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CRLF2

  • Official Full Name

    cytokine receptor-like factor 2

  • Overview

    The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    CRLF2; cytokine receptor-like factor 2; CRL2; TSLPR; IL-XR; TSLP receptor; P2RY8/CRLF2 fusion; cytokine receptor-like 2; cytokine receptor CRL2 precusor; thymic stromal lymphopoietin receptor; thymic stromal lymphopoietin protein receptor; thymic stromal-;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • CHO cells
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • Wheat Germ
  • Fc
  • Fc Chimera
  • Avi
  • Flag
  • GST
  • His
  • His (Fc)
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CRLF2-76H Active Recombinant Human CRLF2, Fc-tagged Mammalian cells Fc
Human CRLF2-30H Active Recombinant Human CRLF2 Protein, Fc-tagged, Alexa Fluor® 647 conjugated NS0 Fc
Human CRLF2-29H Active Recombinant Human CRLF2 Protein, Fc-tagged, Alexa Fluor® 488 conjugated NS0 Fc
Human CRLF2-051H Active Recombinant Human CRLF2 protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi Gly25 & Val30-Lys231
Human CRLF2-1891H Recombinant Human CRLF2 Protein, GST-tagged Wheat Germ GST
Human CRLF2-7578H Recombinant Human CRLF2, His-tagged E.coli His 23-231aa
Human CRLF2-75H Recombinant Human CRLF2, MYC/DDK-tagged HEK293 Myc/DDK
Human CRLF2-7275HCL Recombinant Human CRLF2 293 Cell Lysate HEK293 N/A
Human CRLF2-46H Recombinant Human CRLF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CRLF2-2069HF Recombinant Full Length Human CRLF2 Protein, GST-tagged In Vitro Cell Free System GST 232 amino acids
Human CRLF2-373H Active Recombinant Human CRLF2 protein, Fc-tagged HEK293 Fc Gly 25 - Lys 231
Human CRLF2-46H-B Recombinant Human CRLF2 Protein Pre-coupled Magnetic Beads HEK293
Human CRLF2-3650HFL Recombinant Full Length Human CRLF2, Flag-tagged Mamanlian cells Flag
Human CRLF2-77H Recombinant Human CRLF2 Protein, His-tagged HEK293 His Met1-Lys231
Human CRLF2-845H Recombinant Human CRLF2 Protein, His&GST-tagged E.coli N-His&GST Glu28-Lys231
Mouse Crlf2-450M Active Recombinant Mouse Crlf2, Fc Chimera Mammalian cells Fc Chimera
Mouse Crlf2-452M Recombinant Mouse Crlf2 protein, His-tagged HEK293 His Ala20-Leu233
Mouse CRLF2-3917M Recombinant Mouse CRLF2 Protein Mammalian Cell His
Mouse Crlf2-451M Recombinant Mouse Crlf2 protein, Fc-tagged HEK293 Fc Ala20-Leu233
Mouse Crlf2-846M Recombinant Mouse Crlf2 Protein, His-tagged E.coli N-His Val32-Ala160
Mouse Crlf2-129M Recombinant Mouse Crlf2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CRLF2-1986M Recombinant Mouse CRLF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Crlf2-129M-B Recombinant Mouse Crlf2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Crlf2-6614M Recombinant Mouse Crlf2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse CRLF2-1986M-B Recombinant Mouse CRLF2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CRLF2-7424Z Recombinant Zebrafish CRLF2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CRLF2 Related Research Area

CRLF2 involved in several pathways and played different roles in them. We selected most pathways CRLF2 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRLF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIl6ra;CD40LG;PRP2;IL2RGB;IL2RGA;ACVR2AA;CCL28;IL3;Ccl21a
Jak-STAT signaling pathwayLEPR;CSH;PIK3R2;IL24;IL4R;MCL1;STAM;STAT1B;IL13RA2

CRLF2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CRLF2 itself. We selected most functions CRLF2 had, and list some proteins which have the same functions with CRLF2. You can find most of the proteins on our site.

Function Related Protein

CRLF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRLF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CRLF2.

  • Q&As
  • Reviews

Q&As (6)

Ask a question
How does CRLF2 protein interact with other proteins? 05/11/2023

The protein may interact with other proteins to fulfill its function. These interactions can involve various types of protein-protein interactions like electrostatic interactions, hydrogen bonding, etc. Understanding these interactions can help unravel the mechanism of action of the CRLF2 protein in cells.

How is the expression level of CRLF2 protein regulated? 07/30/2022

The expression level of CRLF2 protein may be regulated by a variety of factors, including gene transcription, translation, post-transcriptional modification, etc. Studying these regulatory mechanisms can help to understand the expression patterns of CRLF2 protein in organisms and its impact on biological processes.

What are the effects of mutations or modifications in the CRLF2 protein on organisms? 10/30/2021

Mutations or modifications of the CRLF2 protein may affect its function and thus affect the organism. The specific effects may vary depending on the type and location of the mutation or modification and may involve various biological processes, such as growth and development, immune response, etc.

In which biological processes does CRLF2 protein play a role? 10/21/2021

CRLF2 protein may be involved in a variety of biological processes, including immune response, regulation of hematopoietic processes, cell growth and differentiation, etc. These processes require the regulatory effect of CRLF2 protein for normal life activities.

What is the structure and function of CRLF2 protein? 04/04/2021

Studying the structure and function of CRLF2 protein may require the design of a series of experiments, including biochemical and cell biology experiments. For example, X-ray crystal diffraction can be used to study its structure, and its function can be studied by gene knockout or knockdown techniques.

How to evaluate the potential of CRLF2 protein as a drug target? 12/29/2020

Evaluating the potential of CRLF2 protein as a drug target may involve several aspects, including its expression level in organisms, its role in biological processes, and its changes in disease. In addition, factors such as ease of drug development for this protein and potential drug side effects need to be considered. At the same time, in vitro and in vivo experiments can be performed with known CRLF2 inhibitors or agonists to verify their efficacy and safety.

Customer Reviews (3)

Write a review
Reviews
03/02/2023

    CRLF2 is highly expressed, which is convenient for detection and quantification.

    06/11/2022

      Green and pollution-free, it can be seen that the manufacturer is very environmentally conscious.

      10/01/2020

        The range of applications is breathtaking, and it can play an important role in any field.

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