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CRX

Official Full Name

cone-rod homeobox
Overview

The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
Synonyms

CRX; cone-rod homeobox; CORD2; cone-rod homeobox protein; CRD; LCA7; orthodenticle homeobox 3; OTX3; Cone rod homeobox; Cone rod homeobox protein; CORD 2; CRX_HUMAN; LCA 7; OTX 3; OTTHUMP00000244137; OTTHUMP00000244138; OTTHUMP00000244139;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His|Myc
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CRX-26342TH	Recombinant Human CRX	Wheat Germ	N/A	299 amino acids	Inquiry
Human	CRX-1919H	Recombinant Human CRX Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CRX-26343TH	Recombinant Human CRX	Wheat Germ	N/A	95 amino acids	Inquiry
Human	CRX-7270HCL	Recombinant Human CRX 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CRX-2671H	Recombinant Human CRX Protein (1-299 aa), His-Myc-tagged	E.coli	His/Myc	1-299 aa	Inquiry
Human	CRX-93HF	Recombinant Full Length Human CRX Protein	In Vitro Cell Free System		299 amino acids	Inquiry
Human	CRX-3854H	Recombinant Human CRX protein, His-tagged	E.coli	His	166-285 aa	$319 / 25ug
Human	CRX-2124HF	Recombinant Full Length Human CRX Protein, GST-tagged	In Vitro Cell Free System	GST	299 amino acids	Inquiry
Zebrafish	CRX-9413Z	Recombinant Zebrafish CRX	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CRX Related Articles
CRX Related Research Area

CRX involved in several pathways and played different roles in them. We selected most pathways CRX participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CRX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

CRX has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding, leucine zipper domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRX itself. We selected most functions CRX had, and list some proteins which have the same functions with CRX. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA binding	HIST2H3A;NFATC4;MED1;CREB1;ELF1;CHD7;CTCFL;SNAI3;H2AFZ
chromatin binding	TCF3;TFAP2A;CTBP2;ARNTL1B;TAF2;NFATC2;UXT;NCOA5;PELP1
leucine zipper domain binding	DDIT3;PMF1;NRL;KCNA3;ERC1;CRX;PAWR;DAPK3;AATF
nuclear hormone receptor binding	CRY1;MED1;SNW1;MYOD1;CTNNB1;Ankar;NCOA3;SMARCD3;NCOA2
protein binding	FAM9C;CMTM5;HNF4A;DPP4;ADAM10;ADNP;BAHD1;RPL37A;PFN2
transcription factor activity, sequence-specific DNA binding	RFX3;T;GATA5;MYCA;ZNF37A;POU4F2;POU2F1B;ZNF187;DRAP1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	ARID3B;CEBPG;NEUROD6;PITX2;ESRRA;OTX1;MYBL1;ONECUT2;NFATC2

CRX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRX here. Most of them are supplied by our site. Hope this information will be useful for your research of CRX.

ROR2; 767; PRKAB2; GCM2; STK16

Liu, Y; Zhong, XF; et al. p16(INK4a) expression in retinoblastoma: a marker of differentiation grade. DIAGNOSTIC PATHOLOGY 9:-(2014).

Maroof, A; Yorgensen, YM; et al. Intranasal Vaccination Promotes Detrimental Th17Mediated Immunity against Influenza Infection. PLOS PATHOGENS 10:-(2014).

Retinal Stem Cell Markers