CRY2
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Official Full Name
cryptochrome 2 (photolyase-like)
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Overview
Cryptochromes (from the Greek κρυπτ? χρ?μα, hidden colour) are a class of blue light-sensitive flavoproteins found in plants and animals. Cryptochromes are involved in the circadian rhythms of plants and animals, and in the sensing of magnetic fields in a number of species. The name Cryptochrome was proposed as a pun combining the cryptic nature of the photoreceptor, and the cryptogamic organisms on which many blue light studies were carried out. -
Synonyms
CRY2; cryptochrome 2 (photolyase-like); cryptochrome-2; growth-inhibiting protein 37; HCRY2; PHLL2; FLJ10332; KIAA0658;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Arabidopsis thaliana
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- His|SUMO|Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
CRY2 involved in several pathways and played different roles in them. We selected most pathways CRY2 participated on our site, such as BMAL1:CLOCK,NPAS2 activates circadian gene expression, Circadian Clock, Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRY2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | NAMPT;NRIP1;DBP;HELZ2;CARM1;CRY2;CRY1;NCOA2;CREBBP |
| Circadian Clock | RAI1;CRY2;CPT1A;CSNK1E;HELZ2;NRIP1;CRY1;CARM1;DBP |
| Circadian rhythm | PER3;RBX1;CLOCK;PRKAB1;PRKAA2;ARNTL;CRY2;PRKAA1;PRKAG2 |
| Diurnally regulated genes with circadian orthologs | TOB1;STBD1;ITM2B;NR1D2;GFRA1;DAZAP2;QK;SF3A3;MYF6 |
CRY2 has several biochemical functions, for example, NOT DNA (6-4) photolyase activity, DNA binding, FAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRY2 itself. We selected most functions CRY2 had, and list some proteins which have the same functions with CRY2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT DNA (6-4) photolyase activity | CRY1;CRY2 |
| DNA binding | FOXG1A;LBX1B;HDGF;CHES1;TOPORS;TBR1B;HOXD4A;ARID4A;ZNF329 |
| FAD binding | DAO.1;PRODH;CRY2;COQ6;DERL3;CYB5R3;DAO.3;DAO1;ACOX1 |
| blue light photoreceptor activity | CRY2;CRY1 |
| damaged DNA binding | UNG;APEX1;POLK;PNKP;XPC;PCNA;POLH;RAD23AA;RBBP8 |
| NOT deoxyribodipyrimidine photo-lyase activity | CRY2;CRY1 |
| phosphatase binding | SH3YL1;SPRED1;ELL;MAPK1;PPP1R26;CARHSP1;WNK1;MAGI2;MAPK3 |
| protein binding | DRAXIN;SNX31;THEMIS;SRGAP1;RAD23B;EMD;POLD3;RPH3A;QKI |
| single-stranded DNA binding | CDAN1;WBP11;NME2;C10orf2;ERCC4;MCM7;TREX1;NUP35;BRCA2 |
| transcription factor activity, transcription factor binding | TRP63;LDB2A;LDB1B;LDB2B;LDB1A;HIF1A;PER1;ASCL1;ASCL1A |
| transcription regulatory region sequence-specific DNA binding | PITX2;PER2;CREB3L3;NFE2L2B;TFAP2A;SFPQ;MKL1;ATF3;NFE2 |
| ubiquitin binding | CRY1;UCHL1;RNF31;KCNS1;SMAD3;TSG101;D17WSU92E;IDE;UBR5 |
CRY2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRY2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CRY2.
PDE9A; CTBP1; MTUS2; Csnk1e; TIMELESS; ATXN1; STK11; CSNK1E; PER3
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