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CSE1L

  • Official Full Name

    CSE1 chromosome segregation 1-like

  • Overview

    Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.
  • Synonyms

    CSE1L; CSE1 chromosome segregation 1-like (yeast); chromosome segregation 1 (yeast homolog) like; exportin-2; CAS; CSE1; XPO2; exp2; importin-alpha re-exporter; chromosome segregation 1-like protein; cellular apoptosis susceptibility protein; MGC117283; M;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • in vitro E. coli
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • SUMO
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CSE1L-1959H Recombinant Human CSE1L Protein, GST-tagged Wheat Germ GST
Human CSE1L-9523HCL Recombinant Human CSE1L Over-expression Cell Lysate HEK293T Myc/DDK
Human CSE1L-27394TH Recombinant Human CSE1L Wheat Germ N/A 100 amino acids
Human CSE1L-9523H Recombinant Human CSE1L protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CSE1L-27953TH Recombinant Human CSE1L Wheat Germ N/A 195 amino acids
Human CSE1L-212HFL Recombinant Full Length Human CSE1L Protein, C-Flag-tagged Mammalian cells Flag
Human CSE1L-2732H Recombinant Human CSE1L Protein (1-200 aa), His-SUMO-tagged in vitro E. coli His/SUMO 1-200 aa
Human CSE1L-95HF Recombinant Full Length Human CSE1L Protein In Vitro Cell Free System 195 amino acids
Human CSE1L-670H-B Recombinant Human CSE1L Protein Pre-coupled Magnetic Beads HEK293
Human CSE1L-670H Recombinant Human CSE1L Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CSE1L-2363H Recombinant Human CSE1L protein, His-SUMO-tagged E.coli His-SUMO 1-200aa
Human CSE1L-2152HF Recombinant Full Length Human CSE1L Protein, GST-tagged In Vitro Cell Free System GST 195 amino acids
Rhesus Macaque CSE1L-1049R Recombinant Rhesus monkey CSE1L Protein, His-tagged Mammalian Cell His
Rhesus Macaque CSE1L-874R-B Recombinant Rhesus Macaque CSE1L Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CSE1L-874R Recombinant Rhesus Macaque CSE1L Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CSE1L-11497Z Recombinant Zebrafish CSE1L Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CSE1L involved in several pathways and played different roles in them. We selected most pathways CSE1L participated on our site, such as Direct p53 effectors, p53 pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSE1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Direct p53 effectorsPCBP4;DDX5;GDF15;DDB2;BNIP3L;FDXR;CEBPZ;PPM1J;RNF144B
p53 pathwayNEDD8;SMYD2;HUWE1;KAT8;FBXO11;DYRK2;CSE1L;TTC5;TRIM28

CSE1L has several biochemical functions, for example, Ran GTPase binding, nuclear export signal receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSE1L itself. We selected most functions CSE1L had, and list some proteins which have the same functions with CSE1L. You can find most of the proteins on our site.

Function Related Protein
Ran GTPase bindingRANGRF;TNPO2;XPO1;RANBP2;RANBP3;DPY19L2;KPNB1;NXT1;IPO4
nuclear export signal receptor activityCSE1L;NUPL2;XPO7;XPO4
protein bindingTUFM;G3BP1;WDR77;GSE1;CCDC155;RARG;MAFB;RANGAP1;NGB

CSE1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSE1L here. Most of them are supplied by our site. Hope this information will be useful for your research of CSE1L.

TP53; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; LRRK2; USP19; TNFRSF1B; NRIP1; YWHAG; YWHAZ; IKBKG; HNRNPL; RPL22; PPP5C

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