CSF1
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Official Full Name
colony stimulating factor 1 (macrophage)
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Overview
Macrophage colony-stimulating factor, or M-CSF, is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. (See colony-stimulating factor.) M-CSF binds to the Colony stimulating factor 1 receptor. It may also be involved in development of the placenta. -
Synonyms
CSF1; colony stimulating factor 1 (macrophage); MCSF; MGC31930; macrophage colony-stimulating factor 1; CSF-1; lanimostim; OTTHUMP00000013362; OTTHUMP00000013363; OTTHUMP00000013364; OTTHUMP00000013365; macrophage colony stimulating factor; M-CSF;
- Recombinant Proteins
- GMP Proteins
- Cell & Tissue Lysates
- Transfected Stable Cell Lines
- Bovine
- Chicken
- Cynomolgus
- Cynomolgus/Rhesus
- Homo sapiens (Human)
- Human
- Human, Cynomolgus
- Mouse
- Mus musculus (Mouse)
- Rat
- B.mori
- Barley Grain
- CHO
- E.coli
- E.coli expression system
- HEK293
- HEK293F
- HEK293T
- Hordeum Vulgare
- Human
- Human Cell
- Human cells
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Silkworm
- Wheat Germ
- Yeast
- C
- His
- Myc
- DDK
- Fc
- GST
- His(C
- ter)
- His|GST
- His|S
- Avi
- MYC
- Myc|DDK
- N/A
- N
- Strep II
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- CSF1 Related Articles
- CSF1 Related Research Area
CSF1 involved in several pathways and played different roles in them. We selected most pathways CSF1 participated on our site, such as Cytokine-cytokine receptor interaction, Cytokines and Inflammatory Response, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | IL10RA;KDR;CXCL11;Pdgfa&Pdgfb;CTF1;TNFSF10;IL3;CSF3R;NGFR |
Cytokines and Inflammatory Response | CSF2;CSF1;CSF3 |
Hematopoietic cell lineage | GM13305;CD34;ITGA6;ITGA3;Itgam&Itgb2;IL5;CSF3R;THPO;TNF |
Integrins in angiogenesis | CSF1R;CSF1;ANGPTL3;EDIL3;MFGE8 |
Osteoclast differentiation | SIRPG;FOS;MAPK13;LILRB2;FOSB;FOSL2;PPP3R2;IFNAR1;MAPK10 |
PI3K-Akt signaling pathway | CSF1R;CSF1;LAMC3;CHAD;CSF3R;EFNA2;PIK3AP1;COMP;CSH2 |
Rap1 signaling pathway | CSF1;LOC608458;PFN4;RGS14;EFNA4;EFNA2 |
Ras signaling pathway | MET;FGF7;FIGF;PLD2;ANGPT1;KSR1;NRAS;VEGFB;PLA2G2F |
CSF1 has several biochemical functions, for example, cytokine activity, growth factor activity, macrophage colony-stimulating factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSF1 itself. We selected most functions CSF1 had, and list some proteins which have the same functions with CSF1. You can find most of the proteins on our site.
Function | Related Protein |
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cytokine activity | CMTM8;BMP1;IL13;CMTM4;VEGFA;IFNA4;TNFSF13;IL9;IL32 |
growth factor activity | GDF5;FGF12A;KITLG;GMFB;RABEP1;LACRT;LEFTY1;NRG3;NTF3 |
macrophage colony-stimulating factor receptor binding | STAP1;IL34;CSF1 |
protein binding | COX8A;RARG;RECK;POLR1A;DNAJB5;LPXN;NPHP4;CASP1;HMGA2 |
protein homodimerization activity | NADK2;CD200;WRN;GABRR1;UGT1A9;ATPIF1B;DNTTIP1;SRR;PLOD1 |
CSF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSF1.
SGTA; FHL3; NOTCH2NL; adhC; MYC
- Q&As
- Reviews
Q&As (5)
Ask a questionCSF1 is implicated in tumor-associated macrophages, influencing tumor growth, invasion, and the tumor microenvironment.
Side effects may include immune-related adverse events, inflammation, and alterations in white blood cell counts.
Yes, there is ongoing research on combining CSF1-targeted therapies with other immunotherapies or conventional treatments to enhance efficacy.
Challenges include maintaining the balance of immune responses, potential off-target effects, and variability in patient responses.
Studies are exploring its role in neuroinflammation, neuroprotection, and potential therapeutic interventions for conditions like Alzheimer's disease.
Customer Reviews (3)
Write a reviewThe CSF1 protein is renowned for its exceptional quality and reliability, making it an ideal choice to fulfill my experimental requirements.
With its high purity and stability, this protein ensures dependable and accurate results, which are crucial for the success of my research endeavors.
Whether it is for investigating cellular pathways, studying protein functions, or exploring signaling cascades, the CSF1 protein offers unparalleled versatility and performance.
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