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CST3

  • Official Full Name

    cystatin C

  • Overview

    The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Dec 2013]
  • Synonyms

    CST3; cystatin C; ARMD11; cystatin-C; cystatin 3; cystatin-3; gamma-trace; post-gamma-globulin; bA218C14.4 (cystatin C); neuroendocrine basic polypeptide;

  • Recombinant Proteins
  • Native Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Antibody
  • Cattle
  • Chicken
  • Dog
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human
  • Human Cell
  • Human Urine - chronic protein renal tubular proteinuria
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • P.pastoris
  • Rabbit
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CST3-1914H Active Recombinant Human Cystatin C HEK293 N/A
Human CST3-3172H Recombinant Human CST3, His tagged Human Cell His
Human CST3-692H Recombinant Human CST3 Mammalian Cell His
Human CST3-2713H Recombinant Human Cystatin C P.pastoris N/A
Human CST3-376H Recombinant Human CST3 protein E.coli N/A 120
Human CST3-3666H Recombinant Human CST3, His-tagged E.coli His
Human CST3-11643H Recombinant Human CST3, GST-tagged E.coli GST 25-146a.a.
Human CST3-3667H Human Cystatin C 1r4c N/A
Human CST3-4309H Native Human CST3 Protein Human N/A
Human CST3-2025H Recombinant Human CST3 Protein, GST-tagged Wheat Germ GST
Human CST3-50H Recombinant Human CST3 protein, His-tagged E.coli His
Human CST3-222H Recombinant Human CST3 Protein HEK293 N/A
Human CST3-2991HCL Recombinant Human CST3 cell lysate Human Cell N/A
Human CST3-3355H Recombinant Human CST3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CST3-6H Cystatin C in Human Serum Reference Standard N/A
Human CST3-11H Active Human Cystatin C Reference Standard N/A
Human CST3-1845H Recombinant Human CST3 Protein (Gly26-Ala146), N-His tagged E.coli N-His Gly26-Ala146
Human CST3-1846H Recombinant Human CST3 Protein (Ser27-Ala146), C-His tagged Mammalian cells C-His Ser27-Ala146
Human CST3-26152TH Native Human CST3 N/A
Human CST3-859H Recombinant Human CST3 Protein, His-tagged HEK293F N-His Ser27-Ala146
Human CST3-2236HF Recombinant Full Length Human CST3 Protein, GST-tagged In Vitro Cell Free System GST 146 amino acids
Human CST3-1847H Recombinant Human CST3 Protein (Ser27-Ala146) Mammalian cells Tag Free Ser27-Ala146
Human CST3-8100H Native Human Cystatin C (Cystatin 3) Human Urine - chronic protein renal tubular proteinuria N/A
Human CST3-2641H Active Recombinant Human CST3 protein, His-tagged HEK293 His Met1-Ala146
Human CST3-2744H Recombinant Human CST3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CST3-1849H Recombinant Human CST3 Protein (Val21-Ala146), C-His tagged E.coli C-His Val21-Ala146
Human CST3-2044H Recombinant Human CST3 Protein, His-tagged HEK293 His Met1-Ala146
Human CST3-3020H Recombinant Human CST3 protein, His-tagged E.coli His 25-146 aa
Human CST3-2744H-B Recombinant Human CST3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cst3-3669M Recombinant Mouse Cst3, His-tagged E.coli His
Mouse Cst3-2205M Active Recombinant Mouse Cst3 protein, His-tagged HEK293 His Met1-Ala140
Mouse Cst3-246M Recombinant Mouse Cystatin C, His-tagged E.coli His
Mouse CST3-373M Recombinant Mouse CST3 Protein, His-tagged Insect Cell His
Mouse CST3-2470MCL Recombinant Mouse CST3 cell lysate Human Cell N/A
Mouse CAB11520RM Rabbit Anti-Mouse Cystatin C Monoclonal Antibody Rabbit N/A
Mouse Cst3-35M Mouse Cystatin C Reference Standard N/A
Mouse Cst3-7182M Recombinant Mouse Cst3 Protein, His-tagged Insect Cell His 21-140
Mouse Cst3-946M Recombinant Mouse Cst3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Cst3-2748M Recombinant Mouse Cst3 protein, His&Myc-tagged E.coli His&Myc 21-140aa
Rat Cst3-4094R Recombinant Rat Cst3 protein, His-tagged HEK293 His Met1-Ala140
Rat CST3-1645R Recombinant Rat CST3 Protein Mammalian Cell His
Rat Cst3-3670R Recombinant Rat Cst3, His-tagged E.coli His
Rat Cst3-253R Recombinant Rat Cystatin C, His-tagged E.coli His
Rat Cst3-33R Recombinant Rat Cst3 Protein, His-tagged Insect Cell His
Rat CST3-1938RCL Recombinant Rat CST3 cell lysate Human Cell N/A
Rat CST3-1303R-B Recombinant Rat CST3 Protein Pre-coupled Magnetic Beads HEK293
Rat Cst3-76R Rat Cystatin C Reference Standard N/A
Rat CST3-1303R Recombinant Rat CST3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Dog CST3-860D Recombinant Dog CST3 Protein, His-tagged E.coli N-His Ala46-Lys147
Cattle CST3-7897C Recombinant Cattle CST3 protein, His-tagged E.coli His Gly32~Asp148 (Accession # P01035)
Rhesus Macaque CST3-1068R Recombinant Rhesus monkey CST3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CST3-893R Recombinant Rhesus Macaque CST3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CST3-893R-B Recombinant Rhesus Macaque CST3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CST3-3366Z Recombinant Zebrafish CST3 Mammalian Cell His
Pig CST3-7899P Recombinant Pig CST3 protein, His & GST-tagged E.coli His/GST Ala42~Val127 (Accession # Q0Z8R0)
Chicken CST3-7898C Recombinant Chicken CST3 protein, His-tagged E.coli His Ala46~Lys147 (Accession # XM_003639821.1)
Chicken CST3-7049C Recombinant Chicken CST3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CST3 Related Articles

CST3 involved in several pathways and played different roles in them. We selected most pathways CST3 participated on our site, such as Amyloid formation, Integrated Pancreatic Cancer Pathway, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with CST3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amyloid formationHIST3H2BB;CST3;APCS;CALCA;SAA1;ODAM;HIST2H3C;NAT8B;TGFBI
Integrated Pancreatic Cancer PathwayFST;DAXX;IL11;MYT1;TOP2A;GPRC5A;RB1CC1;AGA;NOXA1
Metabolism of proteinsMAN1A2;SEC61B;KLHDC3;CKAP4;LDHD;MIA3;PAM16;IGFBP2;ARSH
Salivary secretionITPR3;PLCB1;AMY1B;TRPV6;CALML3;SLC9A1;PRKACA;KCNN4;GNAS

CST3 has several biochemical functions, for example, beta-amyloid binding, cysteine-type endopeptidase inhibitor activity, endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CST3 itself. We selected most functions CST3 had, and list some proteins which have the same functions with CST3. You can find most of the proteins on our site.

Function Related Protein
beta-amyloid bindingITM2C;CHRNA7;OLFM1;SORL1;APOE;APOEA;Apba1;APBA3;COL25A1
cysteine-type endopeptidase inhibitor activityNAIP1;CARD17;AHSG1;LCN1;CTLA2B;BIRC5A;CST4;CSTA;CARD16
endopeptidase inhibitor activityWFDC2;PCSK1N;STFA1;SERPINF2;RENBP;C3A.6;SPINK1;SERPIND1;SERPINA1D
identical protein bindingTK1;BNIP3;SH3BP4;PCNA;MYOM1;HSPB8;SERPINA1D;DPY30;CASC3
protease bindingCD70;INS2;CNTNAP2;IL1R1;SERPINA1D;BCL10;DVL3;FN1;CHL1
protein bindingULK3;GTF2B;NFASC;CD33;S100A12;KCNA2;CETN2;KIF1B;CLIC1

CST3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CST3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CST3.

ATXN1; proS; gmhB; ALB

Wuttke, M; Schaefer, F; et al. Genome-Wide Association Studies in Nephrology: Using Known Associations for Data Checks. AMERICAN JOURNAL OF KIDNEY DISEASES 65:217-222(2015).
Lamontagne, M; Timens, W; et al. Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction. THORAX 69:997-+(2014).
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