CTCF
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Official Full Name
CCCTC-binding factor (zinc finger protein)
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Overview
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] -
Synonyms
CTCF; CCCTC-binding factor (zinc finger protein); MRD21; transcriptional repressor CTCF; CTCFL paralog; 11-zinc finger protein; 11 zinc finger transcriptional repressor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- Tag Free
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | CTCF-26436TH | Recombinant Human CTCF | Wheat Germ | N/A | 100 amino acids | |
Human | CTCF-15H | Recombinant Human CTCF protein | E.coli | N/A | ||
Human | CTCF-16H | Recombinant Human CTCF protein, GST-tagged | Wheat Germ | GST | ||
Human | CTCF-7213HCL | Recombinant Human CTCF 293 Cell Lysate | HEK293 | N/A | ||
Human | CTCF-730HF | Recombinant Full Length Human CTCF Protein, GST-tagged | In Vitro Cell Free System | GST | 727 amino acids | |
Human | CTCF-2364H | Recombinant Human CTCF protein, His-tagged | E.coli | His | 266-727aa | |
Human | CTCF-1699H | Recombinant Human CTCF Protein (Met1-Ile154), N-His tagged | E.coli | N-His | Met1-Ile154 | |
Human | CTCF-1700H | Recombinant Human CTCF Protein (Met1-Ile154) | E.coli | Tag Free | Met1-Ile154 | |
Mouse | CTCF-4013M | Recombinant Mouse CTCF Protein | Mammalian Cell | His | ||
Mouse | CTCF-2043M | Recombinant Mouse CTCF Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | CTCF-2043M-B | Recombinant Mouse CTCF Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | CTCF-1651R | Recombinant Rat CTCF Protein | Mammalian Cell | His | ||
Rat | CTCF-1310R | Recombinant Rat CTCF Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | CTCF-1310R-B | Recombinant Rat CTCF Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | CTCF-253Z | Recombinant Zebrafish CTCF | Mammalian Cell | His | ||
Chicken | CTCF-6884C | Recombinant Chicken CTCF | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- CTCF Related Articles
CTCF involved in several pathways and played different roles in them. We selected most pathways CTCF participated on our site, such as SIDS Susceptibility Pathways, TGF-beta Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTCF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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SIDS Susceptibility Pathways | CTCF;KCNQ1;CC2D1A;EN1;SST;CDCA7L;POU3F2;ECE1;SCN3B |
TGF-beta Receptor Signaling Pathway | HOXD9A;STK11IP;DAB2;RUNX2A;NFYBB;STRAP;MEF2AA;COPS5;CTCF |
CTCF has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin insulator sequence binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTCF itself. We selected most functions CTCF had, and list some proteins which have the same functions with CTCF. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
RNA polymerase II core promoter proximal region sequence-specific DNA binding | RFX4;CTCFL;JUNBB;SREBF2;ASCL1;TCF12;IFI203;HHEX;SIX2 |
chromatin insulator sequence binding | |
protein binding | APOA2;FAF2;GORAB;TMEM41A;KRT81;PARVG;ZBTB17;SOCS5;SURF1 |
sequence-specific DNA binding | NR5A2;EOMES;HOXC9;ZFP536;RBPJ;NR2F1A;AHR2;GATAD1;AHR |
transcription corepressor activity | TLE2;ARHGAP35;AES;BRD7;E2F7;BASP1;CCND1;ALX1;TGIF1 |
transcription factor activity, sequence-specific DNA binding | IKZF4;POU4F1;ZNF584;KDM1A;FOXE3;RORA;ZNF789;NR1D2A;TCF7L1B |
transcription regulatory region DNA binding | CDK5RAP2;GATA5;BRCA1;ZNF649;RNF10;NR5A2;TAF2;TBL1X;ZFP746 |
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | FEZF2;CREB3L4;MYF6;MAF;CREBBP;CSRNP2;FOXO3;MAFK;TP53 |
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | ZBTB7A;NKX6;TCF21;MLXIPL;DACH1;BCL11A;SP3;NFIL3-4;TCF3 |
zinc ion binding | ADAM12;ZFP346;PCGF5A;BTY;ZCCHC2;Npepo;LIMA1;LDB3;LMO7B |
CTCF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTCF here. Most of them are supplied by our site. Hope this information will be useful for your research of CTCF.
HDLBP; ZMYM4; KDM5B; mdm2_human_probe; CHD8
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