CTDSP1
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Official Full Name
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
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Overview
This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
CTDSP1; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; NLIIF; nuclear LIM interactor interacting factor; SCP1; small CTD phosphatase 1; NLI-;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
CTDSP1 involved in several pathways and played different roles in them. We selected most pathways CTDSP1 participated on our site, such as BMP receptor signaling, Coregulation of Androgen receptor activity, Regulation of cytoplasmic and nuclear SMAD2/3 signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTDSP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| BMP receptor signaling | CHRDL1;RGMA;GREM1;AHSG;CALML4;HFE2;RGMB;CTDSP1;CTDSPL |
| Coregulation of Androgen receptor activity | TMF1;KDM3A;NRIP1;SVIL;PATZ1;CTDSP2;CARM1;CMTM2A;KDM4C |
| Regulation of cytoplasmic and nuclear SMAD2/3 signaling | CTDSP2;CTDSPL;CTDSP1 |
CTDSP1 has several biochemical functions, for example, CTD phosphatase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTDSP1 itself. We selected most functions CTDSP1 had, and list some proteins which have the same functions with CTDSP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CTD phosphatase activity | CTDSP1;SSU72;CTDP1;RPAP2;PPM1M;CTDSPLB;CTDSP2;CTDSPLA;CTDSPL |
| metal ion binding | CLPX;CDC7;OBSCN;RYBPB;ZNF473;ZNF395;CYP2D10;ZNF444;ASH2L |
| protein binding | RIBC1;METAP2;SCFD1;CCDC110;WLS;APAF1;YOD1;RBM4;ACCS |
CTDSP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTDSP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTDSP1.
CDCA3; MBP; Ctdsp1
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