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Ctla4

  • Official Full Name

    Ctla4 cytotoxic T-lymphocyte-associated protein 4

  • Overview

    CD152 is a 33 kD member of the immunoglobulin superfamily also known as CTLA-4 or Ly-56. It is expressed on activated T and B lymphocytes. CD152 is similar to CD28 in amino acid sequence, structure, and genomic organization and these two receptors share common B7 family counter-receptors (B7-1, B7-2). Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cellmediated immune responses. CD152 is thought to play a role in the induction and maintenance of immunological tolerance, as well as the development of protective immunity and thymocyte regulation.
  • Synonyms

    CD; GSE; GRD4; ICOS; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; Ipilimumab; Yervoy; 477202-00-9; Ticilimumab (= tremelimumab); 745013-59-6;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Therapeutic Proteins
  • GMP Proteins
  • Chromatography Reagents
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bovine
  • Canine
  • Chicken
  • Cynomolgus
  • Cynomolgus monkey
  • Cynomolgus Monkey
  • Cynomolgus/Rhesus
  • Cynomolgus/Rhesus macaque
  • Dog
  • Guinea pig
  • Homo sapiens (Human)
  • Human
  • Monkey
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Rabbit
  • Rat
  • Rhesus Macaque
  • CHO
  • E.coli
  • E.coli expression system
  • Hamster
  • HEK293
  • HEK293 cells
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • NS1
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • APC
  • C
  • Fc
  • Flag
  • hFc
  • His
  • Avi
  • rFc
  • DDK|His
  • DYKDDDDK
  • Fc|His
  • GST
  • hIgG
  • HIgG
  • HIgG1 Fc
  • His (Fc)
  • His|Avi
  • His|Flag|StrepII
  • His|HIgG
  • His|T7
  • SUMO
  • Myc
  • HlgG1 Fc
  • human|IgG1|Fc
  • IgG2a Fc
  • mFc
  • Mouse|IgG2a|Fc
  • N/A
  • N
  • Strep
  • Tag Free
  • Twin Strep
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CTLA4-3256H Active Recombinant Human CTLA4, MIgG2a Fc-tagged NS1 Fc
Human CTLA4-3258H Active Recombinant Human CTLA4, HIgG1 Fc-tagged, mutant CHO Fc
Human CTLA4-2235H Active Recombinant Human CTLA4 protein, Twin Strep-tagged HEK293 Twin Strep Ala 37 - Phe 162
Human CTLA4-593H Active Recombinant Human CTLA4, Fc-tagged, Biotinylated Human Cell Fc
Human CTLA4-01H Active Recombinant Human CTLA4 Protein, His-Tagged Insect Cell His
Human CTLA4-051H Active Recombinant Human CTLA4 protein, Fc/Avi-tagged, Biotinylated HEK293 cells Fc/Avi Ala37-Phe162
Human CTLA4-1598H Recombinant Human Cytotoxic T-lymphocyte-associated Protein 4, Fc-His Sf21 Insect Cell Fc/His
Human CTLA4-1913H Recombinant Human CTLA4, Fc Chimera E.coli Fc
Human CTLA4-2232H Recombinant Human CTLA4 protein, His-tagged HEK293 His Ala37-Phe162
Human CTLA4-228H Recombinant Human CTLA4, C13&N15-labeled HEK293 N/A
Human CTLA4-137H Recombinant Humancytotoxic T-lymphocyte-Associated Protein 4 Sf9 Insect Cell N/A
Human CTLA4-2233H Recombinant Human CTLA4, Fc-His tagged Human Cell Fc/His
Human CTLA4-54H Recombinant Human CTLA4 protein, His-tagged Insect Cell His
Human CTLA4-2075H Recombinant Human CTLA4 Protein, GST-tagged Wheat Germ GST
Human CTLA4-2234H Recombinant Human CTLA4 protein, Fc-tagged HEK293 human/IgG1/Fc 124
Human CTLA4-28029TH Recombinant Human CTLA4, Fc-tagged Fc
Human CTLA4-2073P Recombinant CTLA4 Protein, His-Flag-StrepII-tagged Human Cell His/Flag/StrepII
Human CTLA4-160H Active Recombinant Human CTLA4, Fc-tagged CHO Fc
Human CTLA4-7259H Recombinant Human CTLA4, His-tagged E.coli His 36-161aa
Human CTLA4-255H Recombinant Human CTLA4, His-tagged, Biotinylated HEK293 His
Human CTLA4-256H Active Recombinant Human CTLA4 protein, mFc-Avi-tagged, Biotinylated HEK293 mFc-Avi Ala37-Phe162
Human CTLA4-344H Recombinant Human CTLA4 Protein, DDK/His-tagged HEK293 DDK/His Ala37-Phe162
Human CTLA4-2526HCL Recombinant Human CTLA4 cell lysate Human Cell N/A
Human CTLA4-371H Recombinant Human CTLA4 protein, mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc 126
Human CTLA4-257H Active Recombinant Human CTLA4 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human CTLA4-301345H Recombinant Human CTLA4 protein, GST-tagged E.coli GST Ala37-Asp161
Human CTLA4-P03H Recombinant Human CTLA4, Fc-tagged therapeutic protein CHO Fc
Human CTLA4-499H Recombinant Human CTLA4 Protein (Met1-Phe162), HIgG1 Fc-tagged HEK293 HIgG1 Fc Met1-Phe162
Human CTLA4-8722H Recombinant Human CTLA4 protein, His-tagged (MALS verified) HEK293 His Ala37-Phe162
Human CTLA4-1873H Recombinant Human CTLA4 Protein (Lys36-Asp161), C-Fc tagged Mammalian cells C-Fc Lys36-Asp161
Human CTLA4-155HG GMP Recombinant Human CTLA4 Protein HEK293 Fc
Human CTLA4-135HG Active GMP Recombinant Human CTLA4 protein HEK293 DNA sequence encoding Human CTLA-4(NP_005205.2) was expressed with His tag at the C-terminal.
Human CTLA4-152H Recombinant Human CTLA4 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CTLA4-1874H Recombinant Human CTLA4 Protein (Lys36-Asp161), C-Flag tagged Mammalian cells C-Flag Lys36-Asp161
Human CTLA4-2754H Recombinant Human CTLA4 protein, His-tagged E.coli His 37-162aa
Human CTLA4-2233HAF555 Recombinant Human CTLA4 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 374
Human CTLA4-2232HAF488 Recombinant Human CTLA4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Ala37-Phe162
Human CTLA4-4048H Recombinant Human CTLA4 Protein (Met1-Asp161), C-His tagged Mammalian cells C-His Met1-Asp161
Human CTLA4-500H Active Recombinant Human CTLA4 Protein (Met1-Asp161) HEK293 N/A Met1-Asp161
Human CTLA4-2232HAF647 Recombinant Human CTLA4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Ala37-Phe162
Human CTLA4-2233HAF488 Recombinant Human CTLA4 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 374
Human CTLA4-3876M Active CTLA4 protein-coupled magnetic Beads HEK293 Ala 37 - Phe 162
Human CTLA4-1106H Recombinant Human CTLA4 Protein (Met1-Phe162), HlgG1 Fc-tagged, Biotinylated HEK293 HlgG1 Fc Met1-Phe162
Human CTLA4-2233HF Recombinant Human CTLA4 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 374
Human Ctla4-652H Recombinant Human Ctla4 Protein, Strep-tagged HEK293 Strep 223
Human CTLA4-066H Recombinant Human CTLA4 Protein, ECD, Tag Free, Biotinylated HEK293 Tag Free ECD
Human CTLA4-862H Recombinant Human CTLA4 protein, His-tagged, low endotoxin HEK293 His Ala37-Phe162
Human Ctla4-649H Recombinant Human Ctla4 Protein HEK293 223
Human CTLA4-869H Recombinant Human CTLA4 Protein, His&GST-tagged E.coli N-His&GST Lys36-Asn223
Human CTLA4-067H Recombinant Human CTLA4 Protein, Lys36-Asp161, C-His-Avi tagged, Biotinylated HEK293 C-His-Avi Lys36-Asp161
Human CTLA4-2232HAF555 Recombinant Human CTLA4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Ala37-Phe162
Human Ctla4-651H Recombinant Human Ctla4 Protein, IgG2a Fc-tagged HEK293 IgG2a Fc 223
Human CTLA4-870H Recombinant Human CTLA4 Protein, His&SUMO-tagged E.coli N-His&SUMO Lys36-Asn223
Human CTLA4-1872H Recombinant Human CTLA4 Protein (Lys36-Asp161), C-His tagged Mammalian cells C-His Lys36-Asp161
Human CTLA4-2233HAF647 Recombinant Human CTLA4 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 374
Human CTLA4-572H Recombinant Human CTLA4 Protein (Gln36-Ser161), C-hFc-tagged HEK293 C-hFc Gln36-Ser161
Human CTLA4-0906H Recombinant Human CTLA4 Protein (Ala37-Asp161), N-His tagged E.coli N-His Ala37-Asp161
Human CTLA4-0274H Recombinant Human CTLA4 protein, His-tagged, Biotinylated HEK293 His Met1-Phe162
Human CTLA4-2232HF Recombinant Human CTLA4 Protein, His-tagged, FITC conjugated HEK293 His Ala37-Phe162
Human CTLA4-3229H Recombinant Human CTLA4 protein(Met1-Phe162), rFc-tagged HEK293 C-rFc Met1-Phe162
Human CTLA4-024H Recombinant Human CTLA4 Protein, C-His-tagged E.coli C-His
Human Ctla4-650H Recombinant Human Ctla4 Protein, Fc-tagged HEK293 Fc 223
Human CTLA4 -0273H Active Recombinant Human CTLA4 protein, His-tagged HEK293 His Met1-Phe162
Mouse Ctla4-4556M Active Recombinant Mouse Ctla4, MIgG2a Fc-tagged NS1 Fc
Mouse Ctla4-333M Active Recombinant Mouse Ctla4, MIgG2a Fc-tagged, mutant NS1 Fc
Mouse Ctla4-41M Recombinant Mouse Ctla4 Protein, hIgG-His-tagged Insect Cell His/HIgG
Mouse Ctla4-3261M Recombinant Mouse Ctla4 protein, Fc-tagged HEK293 human/IgG1/Fc Glu36-Phe162
Mouse Ctla4-1717M Recombinant Mouse Ctla4, Fc-His Mammalian cells Fc/His
Mouse Ctla4-3307M Active Recombinant Mouse Ctla4 protein(Met1-Phe162), His-tagged HEK293 C-His Met1-Phe162
Mouse Ctla4-4557M Recombinant Mouse Ctla4 protein, mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc 127
Mouse Ctla4-5839M Recombinant Mouse Ctla4 protein, His & T7-tagged E.coli His/T7 Val45~Ser185 (Accession # P09793)
Mouse CTLA4-2179MCL Recombinant Mouse CTLA4 cell lysate Human Cell N/A
Mouse Ctla4-7168M Recombinant Mouse Ctla4 Protein, hIgG-His-tagged HIgG/His 38-161
Mouse Ctla4-3261MF Recombinant Mouse Ctla4 Protein, hFc-tagged, FITC conjugated HEK293 hFc Glu36-Phe162
Mouse Ctla4-3307MB Recombinant Mouse Ctla4 protein, His-tagged, Biotinylated HEK293 His
Mouse DMABT-H18898 Hamster Anti-CTLA4 Monoclonal Antibody Hamster APC
Mouse Ctla4-5415M Recombinant Mouse Ctla4 Protein (Ala37-Asp161), C-His tagged Mammalian cells C-His Ala37-Asp161
Mouse Ctla4-3307MAF647 Recombinant Mouse Ctla4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Glu36-Phe162
Mouse Ctla4-06M Active Recombinant Mouse Ctla4 Protein, hIgG/His-tagged Insect Cell hIgG/His
Mouse CTLA4-3358M Recombinant Mouse CTLA4 Protein, Fc-tagged CHO Fc
Mouse Ctla4-158M Recombinant Mouse Ctla4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ctla4-3261MAF555 Recombinant Mouse Ctla4 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc Glu36-Phe162
Mouse Ctla4-2755M Recombinant Mouse Ctla4 protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc 36-161aa
Mouse CTLA4-653M Recombinant Mouse CTLA4 Protein HEK293 223
Mouse Ctla4-158M-B Recombinant Mouse Ctla4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ctla4-038M Active Recombinant Mouse Ctla4 Protein, Fc-tagged CHO Fc
Mouse CTLA4-1954M Active Recombinant Mouse CTLA4 protein, hFc-tagged HEK293 hFc Met1-Phe162
Mouse CTLA4-654M Recombinant Mouse CTLA4 Protein, Fc-tagged HEK293 Fc 223
Mouse Ctla4-3307MF Recombinant Mouse Ctla4 Protein, His-tagged, FITC conjugated HEK293 His Glu36-Phe162
Mouse Ctla4-3307MAF488 Recombinant Mouse Ctla4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Glu36-Phe162
Mouse Ctla4-3261MAF647 Recombinant Mouse Ctla4 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc Glu36-Phe162
Mouse CTLA4-655M Recombinant Mouse CTLA4 Protein, IgG2a Fc-tagged HEK293 IgG2a Fc 223
Mouse Ctla4-3307MAF555 Recombinant Mouse Ctla4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Glu36-Phe162
Mouse Ctla4-5619M Recombinant Mouse Ctla4 Protein (Ala37-Asp161), C-Fc tagged Mammalian cells C-Fc Ala37-Asp161
Mouse Ctla4-3261MAF488 Recombinant Mouse Ctla4 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc Glu36-Phe162
Rat Ctla4-5840R Recombinant Rat Ctla4 protein, His & T7-tagged E.coli His/T7 Thr41~Lys192 (Accession # Q62859)
Rat Ctla4-1143R Recombinant Rat Ctla4 protein, Fc-tagged HEK293 human/IgG1/Fc Ile38-Asp161
Rat Ctla4-1144R Recombinant Rat Ctla4 Protein, His-tagged HEK293 His
Rat Ctla4-1143RAF647 Recombinant Rat Ctla4 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc Ile38-Asp161
Rat Ctla4-1143RAF488 Recombinant Rat Ctla4 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc Ile38-Asp161
Rat Ctla4-1144RAF647 Recombinant Rat Ctla4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 137
Rat CTLA4-657R Recombinant Rat CTLA4 Protein, Fc-tagged HEK293 Fc 223
Rat Ctla4-1143RF Recombinant Rat Ctla4 Protein, hFc-tagged, FITC conjugated HEK293 hFc Ile38-Asp161
Rat Ctla4-1144RAF488 Recombinant Rat Ctla4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 137
Rat Ctla4-1144RF Recombinant Rat Ctla4 Protein, His-tagged, FITC conjugated HEK293 His 137
Rat Ctla4-1143RAF555 Recombinant Rat Ctla4 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc Ile38-Asp161
Rat Ctla4-1144RAF555 Recombinant Rat Ctla4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 137
Monkey CTLA4-8852CAF555 Active Recombinant Monkey CTLA4 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc Met1-Asp161, 366
Monkey CTLA4-8852CAF488 Active Recombinant Monkey CTLA4 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc Met1-Asp161, 366
Monkey CTLA4-8852CAF647 Active Recombinant Monkey CTLA4 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc Met1-Asp161, 366
Monkey CTLA4-109CAF555 Active Recombinant Cynomolgus CTLA4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Met1-Asp161, 136
Monkey CTLA4-8852CF Active Recombinant Monkey CTLA4 Protein, Fc-tagged, FITC conjugated HEK293 Fc Met1-Asp161, 366
Monkey CTLA4-109CAF488 Active Recombinant Cynomolgus CTLA4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Met1-Asp161, 136
Monkey CTLA4-109CAF647 Active Recombinant Cynomolgus CTLA4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Met1-Asp161, 136
Monkey CTLA4-109CF Active Recombinant Cynomolgus CTLA4 Protein, His-tagged, FITC conjugated HEK293 His Met1-Asp161, 136
Rabbit CTLA4-372R Recombinant Rabbit CTLA4 protein, Fc-tagged HEK293 human/IgG1/Fc 126
Rabbit CTLA4-656R Recombinant Rabbit CTLA4 Protein, Fc-tagged HEK293 Fc 223
Rabbit CTLA4-1918R Active Recombinant Rabbit CTLA4 protein, His-tagged HEK293 His Lys 36 - Asp 161
Dog CTLA4-1060CAF555 Recombinant Canine CTLA4 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 364
Dog CTLA4-1060CF Recombinant Canine CTLA4 Protein, Fc-tagged, FITC conjugated HEK293 Fc 364
Dog CTLA4-1061CAF488 Recombinant Canine CTLA4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 137
Dog CTLA4-1060CAF488 Recombinant Canine CTLA4 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 364
Dog CTLA4-1061CF Recombinant Canine CTLA4 Protein, His-tagged, FITC conjugated HEK293 His 137
Dog CTLA4-1060CAF647 Recombinant Canine CTLA4 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 364
Dog CTLA4-1061CAF647 Recombinant Canine CTLA4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 137
Dog CTLA4-1061CAF555 Recombinant Canine CTLA4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 137
Bovine CTLA4-4413B Recombinant Bovine CTLA4 Protein Yeast N/A 128aa
Canine CTLA4-1060C Recombinant Canine CTLA4 Protein, Fc-tagged HEK293 Fc
Canine CTLA4-1061C Recombinant Canine CTLA4 Protein, His-tagged HEK293 His
Cynomolgus CTLA4-8852C Active Recombinant Cynomolgus CTLA4 protein, Fc-tagged HEK293 Fc Met1-Asp161
Cynomolgus Monkey CTLA4-192C Active Recombinant Cynomolgus Monkey CTLA4 protein, Fc-tagged HEK293 Fc
Cynomolgus Monkey CTLA4-1047CCL Recombinant Cynomolgus CTLA4 cell lysate Human Cell N/A
Cynomolgus monkey CTLA4-648C Recombinant Cynomolgus monkey CTLA4 Protein, Fc-tagged HEK293 Fc 223
Cynomolgus monkey CTLA4-647C Recombinant Cynomolgus monkey CTLA4 Protein HEK293 223
Cynomolgus/Rhesus CTLA4-354C Active Recombinant Cynomolgus/Rhesus CTLA4 protein, His-tagged HEK293 His Met1-Asp161
Cynomolgus/Rhesus CTLA4-356C Active Recombinant Cynomolgus/Rhesus CTLA4 protein, His-tagged HEK293 His Met1-Asp161
Cynomolgus/Rhesus CTLA4-109C Active Recombinant Cynomolgus/Rhesus CTLA4 protein(Met1-Asp161), His-tagged HEK293 C-His Met1-Asp161
Cynomolgus/Rhesus macaque CTLA4-369C Recombinant Cynomolgus/Rhesus macaque CTLA4 protein, His-tagged HEK293 His 124
Cynomolgus/Rhesus macaque CTLA4-370C Recombinant Cynomolgus/Rhesus macaque CTLA4 protein, Fc-tagged HEK293 human/IgG1/Fc 124
Guinea pig Ctla4-3845G Recombinant Guinea pig Ctla4 Protein (Ala37-Asp161), C-His tagged Yeast C-His Ala37-Asp161
Homo sapiens (Human) RFL18315HF Recombinant Full Length Human Cytotoxic T-Lymphocyte Protein 4(Ctla4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (36-223)
Mus musculus (Mouse) RFL2295MF Recombinant Full Length Mouse Cytotoxic T-Lymphocyte Protein 4(Ctla4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (36-223)
Oryctolagus cuniculus (Rabbit) RFL22810OF Recombinant Full Length Rabbit Cytotoxic T-Lymphocyte Protein 4(Ctla4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (36-223)
Rhesus Macaque CTLA4-1077R Recombinant Rhesus monkey CTLA4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CTLA4-902R-B Recombinant Rhesus Macaque CTLA4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CTLA4-902R Recombinant Rhesus Macaque CTLA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CTLA4-3408C Recombinant Chicken CTLA4 Mammalian Cell His
Kit-1712 CTLA4:B7-1[Biotinylated] Inhibitor Screening Assay Kit N/A
Kit-1713 CTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Ctla4 Related Articles
  • Ctla4 Related Research Area

Ctla4 involved in several pathways and played different roles in them. We selected most pathways Ctla4 participated on our site, such as Adaptive Immune System, Autoimmune thyroid disease, CTLA4 inhibitory signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ctla4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemCYBB;CTLA4;OSCAR;FBXO44;IGKV1-5;OSBPL1A;LRRC41;FAM49BA;CD200R2
Autoimmune thyroid diseaseIL10;CTLA4;IFN-a;CGA;OSTN
CTLA4 inhibitory signaling
Calcineurin-regulated NFAT-dependent transcription in lymphocytesCSF2;IKZF1;DGKA;EGR4;CDK4;JUNB;EGR1;EGR2;CTLA4
Cell adhesion molecules (CAMs)CLDN7B;NRXN3A;ITGAL;SDC4;ITGA6B;CDH1;CLDN7A;MPZL1L;CD274
Costimulation by the CD28 familyCSK;BTLA;THEM4;MAPKAP1;PDPK1A;MAP3K8;CTLA4;HLA-DQB2
Immune SystemKIF2C;CHST13;EIF4G2A;CRP;TNIP2;RAPGEF3;SPSB1;TREX1;PRLRB
Rheumatoid arthritisACP5;ATP6V0A2;CTLA4;HLA-DRB1;ATP6AP1;IL15;TNFSF13B;HLA-DPB1;IL18

Ctla4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ctla4 itself. We selected most functions Ctla4 had, and list some proteins which have the same functions with Ctla4. You can find most of the proteins on our site.

Function Related Protein
protein bindingRECQL4;DNMT1;IRF9;ATF7IP;NOC4L;CTAG1B;CD46;DNAJC7;C12orf50

Ctla4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ctla4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ctla4.

CD86; PIK3R1; CD80; FYN; STAT5A; STAT5B; RAPGEF1; RAB8A; TRIM25; LAX1

Venditti, O; De Lisi, D; et al. Ipilimumab and immune-mediated adverse events: a case report of anti-CTLA4 induced ileitis. BMC CANCER 15:-(2015).
Garin, EH; Reiser, J; et al. Case series: CTLA4-IgG1 therapy in minimal change disease and focal segmental glomerulosclerosis. PEDIATRIC NEPHROLOGY 30:469-477(2015).
  • Q&As
  • Reviews

Q&As (5)

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Are there ongoing clinical trials exploring CTLA-4 inhibitors in combination with other immunotherapies? 05/16/2020

Yes, several clinical trials are investigating the combination of CTLA-4 inhibitors with PD-1 inhibitors and other immunotherapies to improve the overall effectiveness of cancer treatment.

How does the expression of CTLA-4 vary in different types of immune cells? 10/17/2019

CTLA-4 is expressed on various immune cells, including T cells, regulatory T cells (Tregs), and some B cells, contributing to its diverse immunoregulatory functions.

In what ways can CTLA-4 be utilized in organ transplantation? 01/11/2017

Modulating CTLA-4 may have applications in organ transplantation by suppressing the immune response against transplanted tissues and reducing the risk of rejection.

How does CTLA-4 contribute to the maintenance of immune tolerance? 04/30/2016

CTLA-4 is involved in the suppression of autoreactive T cells, contributing to the prevention of autoimmune responses by maintaining immune tolerance.

How does CTLA-4 blockade differ from PD-1/PD-L1 blockade in cancer immunotherapy? 03/18/2016

While both CTLA-4 and PD-1/PD-L1 inhibitors enhance anti-tumor immune responses, they target different checkpoints in the immune system. CTLA-4 primarily regulates T-cell activation in the early stages, whereas PD-1/PD-L1 acts later in the immune response.

Customer Reviews (3)

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Reviews
04/17/2019

    It has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.

    11/25/2018

      The CTLA4 protein is a top-quality product that is sure to fulfill my experimental requirements.

      01/28/2017

        the ease of use and compatibility of the CTLA4 protein with various techniques further enhances its appeal.

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