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CTNNA1

  • Official Full Name

    catenin (cadherin-associated protein), alpha 1, 102kDa

  • Overview

    The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.
  • Synonyms

    alpha catenin; alpha E catenin; alphaE catenin; Cadherin associated protein 102kDa; Cadherin associated protein; CAP 102; CAP102; Catenin (cadherin associated protein) alpha 1 102kDa; Catenin (cadherin associated protein), alpha 1, 102kDa; Catenin alpha 1; CTNNA 1; CTNNA1; FLJ36832; FLJ52416; NY REN 13 antigen; OTHUMP00000224141; OTTHUMP00000224147; Renal carcinoma antigen NY REN 13 alpha catenin; Renal carcinoma antigen NY REN 13; alpha-Cat; a-cat; alpha-ctn; alphacat; CG17947; CT39986; Dalpha-cat; Dalpha-catenin; DalphaC; Dalphacat; Dmcatp; Dmel\CG17947; CG17947-PA; D-alpha-catenin; Dalpha-cadherin; DalphaCatenin; a-catenin; alpha-Cat-PA; alpha-Catenin; alphaCatenin; CG17947 gene product from transcript CG17947-RA;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CTNNA1-168H Recombinant Human CTNNA1 Mammalian Cell His
Human CTNNA1-1440H Recombinant Human CTNNA1,GST-tagged Sf9 Insect Cell GST
Human CTNNA1-11669H Recombinant Human CTNNA1, GST-tagged E.coli GST C-term-349a.a.
Human CTNNA1-2076H Recombinant Human CTNNA1 Protein, GST-tagged Wheat Germ GST
Human CTNNA1-7203HCL Recombinant Human CTNNA1 293 Cell Lysate HEK293 N/A
Human CTNNA1-399H Recombinant Human CTNNA1 Protein, His-tagged E.coli His Thr2~Cys228
Human CTNNA1-2294HF Recombinant Full Length Human CTNNA1 Protein, GST-tagged In Vitro Cell Free System GST 536 amino acids
Human CTNNA1-681H-B Recombinant Human CTNNA1 Protein Pre-coupled Magnetic Beads HEK293
Human CTNNA1-126H Recombinant Human CTNNA1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CTNNA1-681H Recombinant Human CTNNA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CTNNA1-623HFL Recombinant Full Length Human CTNNA1 Protein, C-Flag-tagged Mammalian cells Flag
Mouse CTNNA1-4028M Recombinant Mouse CTNNA1 Protein Mammalian Cell His
Mouse CTNNA1-2055M Recombinant Mouse CTNNA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CTNNA1-2055M-B Recombinant Mouse CTNNA1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ctnna1-777M Recombinant Mouse Ctnna1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque CTNNA1-1078R Recombinant Rhesus monkey CTNNA1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CTNNA1-903R Recombinant Rhesus Macaque CTNNA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CTNNA1-903R-B Recombinant Rhesus Macaque CTNNA1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CTNNA1-9024Z Recombinant Zebrafish CTNNA1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CTNNA1 Related Articles

CTNNA1 involved in several pathways and played different roles in them. We selected most pathways CTNNA1 participated on our site, such as Adherens junction, Adherens junctions interactions, Arf6 trafficking events, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTNNA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adherens junctionSNAI1;WASL;CTNNA1;CSNK2A2A;EP300;AASS;ACTB1;CSNK2A2;FYNA
Adherens junctions interactionsCDH4;CDH3;CADM2;CTNND1;CDH17;CDH8;CADM2B;PVRL2L;CDH5
Arf6 trafficking eventsDNM2;SCAMP2;EXOC3;CHRM2;PTBP3;EXOC1;SPAG9;CTNNA1;CLTC
Arrhythmogenic right ventricular cardiomyopathyDMD;DSG2;CTNNA2;DSP;CTNNA1;CACNG3;DAG1;CACNG2;DSC2
Arrhythmogenic right ventricular cardiomyopathy (ARVC)ITGB3;ITGAV;CACNG2;CACNG3;ITGA3;Itga10&Itgb1;ITGA5;CTNNA3;CACNB2
Bacterial invasion of epithelial cellsPIK3R2;CAV3;ARPC1B;CLTA;DOCK1;ITGA5;WASF2;ARPC5L;BCAR1
CDC42 signaling eventsARPC4;PAK4;CDC42BPA;ARPC3;ARPC1B;BAIAP2;ARPC5;TNK2;IQGAP3
CDO in myogenesisCDON;SPAG9;MEF2AA;CDH2;BNIP2;CDH4;MYOD1;MEF2B;BOC

CTNNA1 has several biochemical functions, for example, actin filament binding, beta-catenin binding, cadherin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTNNA1 itself. We selected most functions CTNNA1 had, and list some proteins which have the same functions with CTNNA1. You can find most of the proteins on our site.

Function Related Protein
actin filament bindingCTNNA3;MYO18A;SMYHC2;TTN;PPP1R9A;WIPF2;TRIOBPB;GAS7;MYO1D
beta-catenin bindingCARM1;SHROOM2;AXIN2;APC2;APC;PROP1;CD2AP;LZIC;DACT1
cadherin bindingAKAP5;CTNNAL1;OLFM4;CD2AP;JUPA;FXYD5;FER;VCL;PSEN1
gamma-catenin bindingTCF7L2;PTBP3;FER;CTNNA1;APC;CDH2;APC2;DSG1A;PTPRK
poly(A) RNA bindingMDH2;RPF1;G3BP2;CRNKL1;LGALS3;FAM103A1;RPL5B;RPL7L1;NSUN2
protein bindingACAA2;BCAP31;INCA1;HPCAL4;VAT1L;CAMK2D;PLSCR1;TLR13;TAGLN
structural molecule activityEVPLA;LAMA2;MAP7D2A;KRT28;KRT40;KRT33B;CLDN19;KRT6C;FGG
vinculin bindingC22orf28;NRAP;PXN;SYNM;DAG1;DMD;SORBS3;CTNNA1;ACTN1

CTNNA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTNNA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTNNA1.

APC; EGFR; CDH1; JUP; ARRB2; CTNNB1; ACTN1; Ctnnb1; Cep350

Harati, K; Slodnik, P; et al. Pro-apoptotic effects of pycnogenol on HT1080 human fibrosarcoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1629-1636(2015).
Lee, B; Yoon, K; et al. Homozygous Deletions at 3p22, 5p14, 6q15, and 9p21 Result in Aberrant Expression of Tumor Suppressor Genes in Gastric Cancer. GENES CHROMOSOMES & CANCER 54:142-155(2015).
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