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CUBN

  • Official Full Name

    cubilin (intrinsic factor-cobalamin receptor)

  • Overview

    Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. [provided by RefSeq, Jul 2008]
  • Synonyms

    CUBN; cubilin (intrinsic factor-cobalamin receptor); IFCR; MGA1; gp280; cubilin; 460 kDa receptor; cubilin precursor variant 1; cubilin precursor variant 2; intestinal intrinsic factor receptor; intrinsic factor-vitamin B12 receptor;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • C
  • His
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CUBN-2226H Recombinant Human CUBN Protein (Cys3511-Ser3623), N-His tagged E.coli N-His Cys3511-Ser3623
Human CUBN-641H Recombinant Human CUBN Protein, His-tagged E.coli His Cys3157~Met3274
Human CUBN-2473H Recombinant Human CUBN protein(391-930 aa), C-His-tagged E. coli C-His 391-930 aa
Mouse CUBN-4073M Recombinant Mouse CUBN Protein Mammalian Cell His
Mouse CUBN-2079M Recombinant Mouse CUBN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cubn-643M Recombinant Mouse Cubn Protein, His-tagged E.coli His Cys3157~Val3274
Mouse CUBN-2079M-B Recombinant Mouse CUBN Protein Pre-coupled Magnetic Beads HEK293
Rat CUBN-1676R Recombinant Rat CUBN Protein Mammalian Cell His
Rat CUBN-1335R Recombinant Rat CUBN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CUBN-1335R-B Recombinant Rat CUBN Protein Pre-coupled Magnetic Beads HEK293
Rat Cubn-645R Recombinant Rat Cubn Protein, His-tagged E.coli His Cys3157~Val3274
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CUBN involved in several pathways and played different roles in them. We selected most pathways CUBN participated on our site, such as Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with CUBN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Vitamin digestion and absorptionMMACHC;TCN2;LRAT;PNLIP;SLC19A1;FOLH1;APOB;SCARB1;BTD

CUBN has several biochemical functions, for example, calcium ion binding, cobalamin binding, cobalamin transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CUBN itself. We selected most functions CUBN had, and list some proteins which have the same functions with CUBN. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingPCDHGA2;CRB1;LRP4;PADI4;DMP1;SYT1A;PLA2G2A;CAPN2;FAT2
cobalamin bindingTCNL;TCN2;CUBN;MMACHC;GIF;LMBRD1;MUT;CD320;TCN1
cobalamin transporter activity
hemoglobin bindingAHSP;LRP2;HP;HPR;CUBN;HBB
identical protein bindingPOLG2;ESR1;KDM6A;CSK;SHMT2;CST3;GLUL;BAX;GBP1
metal ion bindingCLCNKB;ZFP639;ZNF302;DAK;ZFR;PRKCDA;FOXP3;HELZ2;NR4A2A
protein bindingUACA;ATG7;PLRG1;LTC4S;MRPL41;TALDO1;SMARCA5;MRPL51;DPH3
protein homodimerization activityBOKA;LCN2;BCL2A1;HMGCR;CCL5;TBX15;ADRA2C;BNIP3L;KIAA0947
receptor activityGPA33;MED4;LILRA2;TLR4;TNPO3;CD93;GFRA1A;CSF2RA;CLEC4E

CUBN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CUBN here. Most of them are supplied by our site. Hope this information will be useful for your research of CUBN.

Pou5f1; Hsd3b4

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