CUL1
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Official Full Name
cullin 1
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Overview
Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination. This is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, it serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. -
Synonyms
CUL1; cullin 1; MGC149834; MGC149835; cullin-1; CUL-1; OTTHUMP00000202347;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CUL1 Related Articles
CUL1 involved in several pathways and played different roles in them. We selected most pathways CUL1 participated on our site, such as Cell cycle, Oocyte meiosis, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CUL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | HDAC6;TTK;TGFB1;HTATIP;CDK5RAP2;E2F2;DCTN1A;CDC25B;ANAPC5 |
| Oocyte meiosis | CUL1;PPP3CCA;ANAPC5;SKP1;ANAPC4;RPS6KA2;PRKACBB;PLK1;CAMK2D |
| Ubiquitin mediated proteolysis | UBE4A;ANAPC11;WWP2;CUL3B;UBE2QL1;UBR5;SIAH2L;UBE2D1A;PIAS1 |
| Protein processing in endoplasmic reticulum | BAXA;FBXO2;EIF2AK4;CRYAB;CAPN1A;VIMP;RNF185;CRYAA;CRYABA |
| Wnt signaling pathway | PPP3CCB;CCND2A;DKK1;FZD9B;TP53;DAAM1;VANGL2;MAPK8B;CSNK1A1L |
| TGF-beta signaling pathway | GDF6A;NDR1;ID3;BMPR2A;BMPR1BA;BMP4;RBL1;RHOAD;SMAD7B |
| Circadian rhythm | PRKAG3;CSNK1E;RORC;NR1D1;SKP1;PRKAB1;FBXW11;PER3;PRKAG1 |
| Herpes simplex infection | ARNTL1B;HLA-DRB5;OAS3;IFNA21;IL15;CRFB2;SOCS3;HLA-E;CSNK2A2 |
CUL1 has several biochemical functions, for example, protein binding, contributes_to ubiquitin protein ligase activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CUL1 itself. We selected most functions CUL1 had, and list some proteins which have the same functions with CUL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ROPN1;CTNNB1;NOS1AP;PALM;MLLT6;INPP5A;FGF7;PPP6C;VEGFAA |
| contributes_to ubiquitin protein ligase activity | FBXL17;SKP2;FBXL6;FBXL14B;CUL5A;UBXN6;CUL5;FBXL7;FBXL3B |
| ubiquitin protein ligase binding | BRCA1;SMAD5;CUL4A;XBP1;BLZF1;SCN5A;AXIN1;UBE2J1;UBOX5 |
CUL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CUL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CUL1.
RBX1; SKP1
- Q&As
- Reviews
Q&As (5)
Ask a questionTechniques such as immunohistochemistry, Western blotting, and gene expression analysis are commonly used to study CUL1 protein expression and function in clinical research.
Yes, CUL1 protein has been implicated in various diseases, including neurodegenerative disorders and cardiovascular diseases, due to its role in protein degradation and cellular regulation.
While CUL1 protein levels are altered in certain cancers, it is not commonly used as a standalone biomarker. However, it may be part of a panel of markers used for cancer diagnosis.
Yes, mutations in the CUL1 gene have been linked to a rare genetic disorder called Cullin-Ring Ligase 1 Syndrome, which is characterized by developmental delays and intellectual disabilities.
Dysregulation of CUL1 protein can lead to the abnormal degradation of cell cycle regulators, resulting in uncontrolled cell division and potentially contributing to tumorigenesis.
Customer Reviews (3)
Write a reviewI highly recommend the CUL1 protein for a variety of research applications.
It demonstrates excellent performance in ELISA, consistently delivering accurate and reliable results.
the CUL1 protein has proven to be an invaluable tool in protein electron microscopy structure analysis.
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