Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

CUX1

Official Full Name

cut-like homeobox 1
Overview

The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms

CUX1; cut-like homeobox 1; cut (Drosophila) like 1 (CCAAT displacement protein) , cut like 1, CCAAT displacement protein (Drosophila) , CUTL1; protein CASP; CASP; CDP; CDP/Cut; CDP/Cux; CDP1; Clox; CUT; CUX; Cux/CDP; golgi integral membrane protein 6; GO;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse
Mus musculus (Mouse)

Source

E.coli
E.coli expression system
HEK293
HEK293T
Mammalian Cell
Wheat Germ

Tag

GST
His
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CUX1-11709H	Recombinant Human CUX1, GST-tagged	E.coli	GST	C-term-341a.a.	$319 / 25ug
Human	CUX1-2139H	Recombinant Human CUX1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CUX1-424HCL	Recombinant Human CUX1 cell lysate		N/A		Inquiry
Human	CUX1-3381H	Recombinant Human CUX1 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	CUX1-2756H	Recombinant Human CUX1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CUX1-301226H	Recombinant Human CUX1 protein, GST-tagged	E.coli	GST	Met1-Ser341	Inquiry
Human	CUX1-3332H	Recombinant Human CUX1 protein, His-tagged	E.coli	His	1-341 aa	$319 / 25ug
Mouse	Cux1-2382M	Recombinant Mouse Cux1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mus musculus (Mouse)	RFL26395MF	Recombinant Full Length Mouse Protein Casp(Cux1) Protein, His-Tagged	E.coli expression system	His	Full Length (1-678)	Inquiry
Chicken	CUX1-5492C	Recombinant Chicken CUX1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CUX1 Related Articles
CUX1 Related Research Area

CUX1 involved in several pathways and played different roles in them. We selected most pathways CUX1 participated on our site, such as Disease, Diseases of signal transduction, FGFR1 mutant receptor activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CUX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Disease	CUX1;FGFR1OP;RCC1;TLR10;EPM2A;CTBP2;NMT1;CTBP1;OPN1MW
Diseases of signal transduction	OPN1MW2;OS9;HEYL;OPN1SW;KREMEN2;CUX1;FKBP1A;STRA6;HEY1
FGFR1 mutant receptor activation	MYO18A;FGFR1OP2;TRIM24;LRRFIP1;FGFR1OP;CUX1;CPSF6
Signaling by FGFR in disease	FGFR1OP2;CPSF6;TRIM24;LRRFIP1;CUX1;MYO18A
Signaling by FGFR1 fusion mutants	TRIM24;CUX1;FGFR1OP2;MYO18A;CPSF6
Signaling by FGFR1 in disease	CUX1;CPSF6;MYO18A;FGFR1OP2;TRIM24

CUX1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, chromatin binding, protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by CUX1 itself. We selected most functions CUX1 had, and list some proteins which have the same functions with CUX1. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II regulatory region sequence-specific DNA binding	DMRT2;FOXC1;ZBTB16A;E2F7;GATA1A;RARG;FOXD3;BHLHA15;ZIK1
chromatin binding	OVOL2;YBX1;ZFP354B;HDAC5;MTA3;JUN;WACA;STAT5B;SHMT2
protein binding, bridging	IVL;CBX5;COL1A2;DDX20;LOR;NUFIP1;TNNT2A;TRIM5;FGA
sequence-specific DNA binding	TCF7L1B;DLX3B;DBPA;NKX2.3;HOXC12;ATF4;IRX3B;ZNF831;TAF2
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding	ARID3B;SIX6;PROP1;MIXL1;MEOX2;NFE2L2;FOXH1;HCFC1;FUBP1

CUX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CUX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CUX1.

RB1; BIN1; CA12; RECQL5; MAX; q7cl32_yerpe; narX; ELAC2

Gan, XT; Zhao, GJ; et al. Identification of Fat Mass and Obesity Associated (FTO) Protein Expression in Cardiomyocytes: Regulation by Leptin and Its Contribution to Leptin-Induced Hypertrophy. PLOS ONE 8:-(2013).

Ikeda, T; Kumagai, E; et al. Soluble CD26/Dipeptidyl Peptidase IV Enhances the Transcription of IL-6 and TNF-alpha in THP-1 Cells and Monocytes. PLOS ONE 8:-(2013).

Intracellular Signaling Molecules in Angiogenesis