CX3CR1
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Official Full Name
chemokine (C-X3-C motif) receptor 1
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Overview
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] -
Synonyms
CX3CR1; chemokine (C-X3-C motif) receptor 1; V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1; CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1;
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- Rhesus Macaque
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- Wheat Germ
- GST
- His
- His (Fc)
- Avi
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- Involved Pathway
- Protein Function
- Interacting Protein
- CX3CR1 Related Articles
- CX3CR1 Related Gene Family
CX3CR1 involved in several pathways and played different roles in them. We selected most pathways CX3CR1 participated on our site, such as Chemokine receptors bind chemokines, Chemokine signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CX3CR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine receptors bind chemokines | CCRL2;CX3CR1;CCR8;CXCR6;CXCR7B;CCR3;CCR5;CXCL11.8;AMCF-II |
| Chemokine signaling pathway | PRKACB;CXCR3;GM13306;LYN;CCL18;PLCB4;RAP1B;CCL26;CXCR5 |
| Class A/1 (Rhodopsin-like receptors) | MLN;NPFFR2;OPN1LW;PROKR1A;CCR9;GPR37L1;CCL35.2;GPR77;GPBAR1 |
| Cytokine-cytokine receptor interaction | Kitl;IL23;CCL16;BMPR1BA;CCL21B;Ccl9;ACKR3B;IL1RAP;IFNGR1 |
| GPCR ligand binding | PROKR1;CALCB;PROKR1A;CCR1;APLNR;HCAR1-2;APLN;GNB5B;PTGDR2 |
| GPCRs, Class A Rhodopsin-like | CCR1;APLNR;SSTR1;CCBP2;NPFFR2;DRD4;CYSLTR1;OPN1MW2;CMKLR1 |
| Peptide GPCRs | CXCR6;SSTR5;CX3CR1;TAC4;SSTR4;SSTR1 |
| Peptide ligand-binding receptors | EDN2;NMB;QRFP;GPR37B;INSL3;PROKR2;SST;OXTRL;CCL19A.2 |
CX3CR1 has several biochemical functions, for example, C-X3-C chemokine receptor activity, chemokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CX3CR1 itself. We selected most functions CX3CR1 had, and list some proteins which have the same functions with CX3CR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| C-X3-C chemokine receptor activity | |
| chemokine receptor activity | CCR1L1;CCR9;RGRA;CCR9A;CXCR1;CXCR4A;CCRL2;CMKLR1;CXCR3.2 |
| protein binding | EIF1AX;BIRC3;PPIL2;ADRA2A;RYBP;SEC63;NFKBIB;TLE1;DUSP9 |
CX3CR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CX3CR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CX3CR1.
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Q&As (7)
Ask a questionThere are potential therapeutic implications related to CX3CR1 in immune-related disorders, making it a target of interest for drug development.
CX3CR1 contributes to the regulation of immune responses and cell migration by responding to its ligand, fractalkine (CX3CL1).
CX3CR1 is predominantly expressed in certain immune cells, including monocytes, macrophages, and certain subsets of T cells.
CX3CR1 plays a role in influencing the balance between immune tolerance and inflammation through its impact on immune cell function.
Dysregulation or abnormal expression of CX3CR1 is associated with conditions such as atherosclerosis, neuroinflammatory disorders, and certain cancers.
The ligand for CX3CR1, fractalkine (CX3CL1), is involved in immune modulation, influencing cell adhesion and migration.
C-X3-C motif chemokine receptor 1 (CX3CR1) primarily functions in the immune system, playing a role in immune responses and cell migration.
Customer Reviews (3)
Write a reviewThe manufacturer's commitment to meeting regulatory requirements demonstrated its dedication to ethical research practices.
The reliability of the product's quality and effectiveness from one batch to another instilled confidence in its usage.
The product's adherence to regulatory standards aligned with our lab's commitment to responsible and transparent research.
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