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CYP2B6

  • Official Full Name

    cytochrome P450, family 2, subfamily B, polypeptide 6

  • Overview

    This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
  • Synonyms

    CYP2B6; cytochrome P450, family 2, subfamily B, polypeptide 6; CYP2B, cytochrome P450, family 2, subfamily B , cytochrome P450, subfamily IIB (phenobarbital inducible) , cytochrome P450, subfamily IIB (phenobarbital inducible), polypeptide 6; cytochrome P450 2B6; CPB6; CYPIIB6; 11B1; CP2B6_HUMAN; CPB 6; CYP 2B6; CYP IIB6; CYP2B; CYP2B7; CYP2B7P; Cytochrome P450 family 2 subfamily B; Cytochrome P450 family 2 subfamily B polypeptide 6; Cytochrome P450 IIB1; Cytochrome P450 phenobarbital inducible; Cytochrome P450 subfamily IIB (phenobarbital inducible); Cytochrome P450 subfamily IIB (phenobarbital inducible) polypeptide 6; Cytochrome P450 subfamily IIB polypeptide 6; IIB1; P450; P450 IIB1; P450IIB1; cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Cynomolgus Monkey
  • Dog
  • Human
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP2B6-16H Recombinant Human CYP2B6 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CYP2B6-192H Recombinant Human CYP2B6 Mammalian Cell His
Human CYP2B6-17H Recombinant Human CYP2B6 protein, GST-tagged Wheat Germ GST 1 a.a. - 491 a.a.
Human CYP2B6-231H Recombinant Human CYP2B6 Insect Cell N/A
Human CYP2B6-28193TH Recombinant Human CYP2B6 Wheat Germ N/A 491 amino acids
Human CYP2B6-702H-B Recombinant Human CYP2B6 Protein Pre-coupled Magnetic Beads HEK293
Human CYP2B6-4861H Recombinant Human CYP2B6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CYP2B6-21H Active Recombinant Human CYP2B6 Protein E.coli
Human CYP2B6-711HF Recombinant Full Length Human CYP2B6 Protein, GST-tagged In Vitro Cell Free System GST 491 amino acids
Human CYP2B6-22H Active Recombinant Human CYP2B6 Protein E.coli
Human CYP2B6-702H Recombinant Human CYP2B6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CYP2B6-73H Active Recombinant Human CYP2B6 Protein E. coli
Human CYP2B6-108HF Recombinant Full Length Human CYP2B6 Protein In Vitro Cell Free System 491 amino acids
Human CYP2B6-1884HFL Recombinant Full Length Human CYP2B6 Protein, C-Flag-tagged Mammalian cells Flag
Dog CYP2B6-113D Active Recombinant Dog CYP2B6 Protein E. coli
Cynomolgus Monkey CYP2B6-439C Recombinant Cynomolgus CYP2B6 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CYP2B6-184C Recombinant Cynomolgus Monkey CYP2B6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CYP2B6-184C-B Recombinant Cynomolgus Monkey CYP2B6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CYP2B6-1146R Recombinant Rhesus monkey CYP2B6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CYP2B6-971R-B Recombinant Rhesus Macaque CYP2B6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CYP2B6-971R Recombinant Rhesus Macaque CYP2B6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Kit-0917 CYP2B6 Blue Screening Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CYP2B6 Related Articles

CYP2B6 involved in several pathways and played different roles in them. We selected most pathways CYP2B6 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2B6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismPLA2G4D;ALOX12B;CYP2P9;CYP2N13;GPX2;ALOX15B;CYP2C8;CBR2;PTGESL
Biological oxidationsUGT1B1;CYP2K22;CYP3A7-CYP3AP1;ACY3.2;NAT2;AADAC;CYP2C18;CYP4F22;SULT4A1
CYP2E1 reactionsCYP2C19;CYP2S1;CYP2A7;CYP2C9;CYP2A13;CYP2D6;CYP2F1;CYP2Y3;CYP2B6
Cytochrome P450 - arranged by substrate typeCYP11B1;CYP51A1;CYP3A7;CYP1A1;CYP2K18;CYP1B1;CYP2E1;CYP3A7-CYP3AP1;CYP8B2
Drug metabolism - cytochrome P450ADH1C;GSTO2;CYP2E1;GSTK1;CYP2B6;CYP2A6;ADH1B;ADH1A;ADH4
Fatty acidsCYP2AD3;CYP2A13;CYP4F11;CYP2F1;CYP4F12;CYP2D6;CYP2V1;CYP2A7;CYP2AD6
Metabolic pathwaysCMPK1;UGT2A1;B3GAT3;COX11;GNSA;ST6GAL2;ALDOC;AK8;AFMID
MetabolismADAL;APOC2;HS3ST6;TIMMDC1;BCHE;ETFA;MMADHC;CPNE7;CYP3A5

CYP2B6 has several biochemical functions, for example, arachidonic acid epoxygenase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2B6 itself. We selected most functions CYP2B6 had, and list some proteins which have the same functions with CYP2B6. You can find most of the proteins on our site.

Function Related Protein
arachidonic acid epoxygenase activityCYP2A6;CYP2Y3;CYP2C8;CYP2D6;CYP4A11;CYP2C55;CYP2D9;CYP2A4;CYP2F1
heme bindingCYP27C1;CYP2P9;CYP19A1;CYP2J6;CYB5R4;CYP4F22;CYP11B1;CYP1A;CYP2C18
iron ion bindingCYP2C8;CYP2C9;CYP1A1;OGFOD2;CYP2P8;OGFOD3;PLOD3;HBA-X;CYP19A1
monooxygenase activityCOQ6;CYP4V8;CYP51;TYR;CYP2E1;CYP3A43;BCMO1;MOXD1L;CYP3C1L2
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCYP2W1;CYP2C38;CYP2A7;CYP3A25;CYP2C39;CYP2C50;CYP2S1;CYP2Y3;CYP2J5
oxygen bindingHBG2;CYP2P8;CYP2C37;HBAE1;HBAA1;CYP1B1;HBM;CYP2B6;CYGB2
steroid hydroxylase activityCYP2D26;CYP2J6;CYP21A2;CYP2N13;CYP2C50;CYP2C39;CH25H;CYP2C54;CYP2E1

CYP2B6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2B6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2B6.

Liu, ZH; Li, L; et al. Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo. DRUG METABOLISM AND DISPOSITION 43:208-216(2015).
Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
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