cyp2c18
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  • Official Full Name
  • cytochrome P450, family 2, subfamily C, polypeptide 18
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • CYP2C18; cytochrome P450, family 2, subfamily C, polypeptide 18; CYP2C17, cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 18; cytochrome P450 2C18; CPCI; CYP2C; P450IIC17; CYP2C 18; (S) mephenytoin hydroxylase associated cytochrome P450; CYP2C17; CYPIIC18; Cytochrome P450 family 2 subfamily C polypeptide 18; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 17; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 18; Flavoprotein linked monooxygenase; Microsomal monooxygenase; Unspecific monooxygenase; cytochrome P450-6B/29C; flavoprotein-linked monooxygenase; (S)-mephenytoin hydroxylase associated cytochrome P450; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18; P450-6B/29C
Cat.#:CYP2C18-2261HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP2C18 Protein, GST-tagged
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Cat.#:CYP2C18-1147RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP2C18 Protein, His-tagged
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Cat.#:CYP2C18-1153CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CYP2C18
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Cat.#:CYP2C18-434HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP2C18 cell lysate
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CYP2C18 Related Articles

Tsuchida, T; Zheng, YW; et al. The Development of Humanized Liver With Rag1 Knockout Rats. TRANSPLANTATION PROCEEDINGS 46:1191-1193(2014).
Redlich, G; Zanger, UM; et al. Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH 7:4678-4688(2008).