Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

CYP2C8

  • Official Full Name

    cytochrome P450, family 2, subfamily C, polypeptide 8

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.
  • Synonyms

    CYP2C8; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 8; cytochrome P450 2C8; CPC8; CYPIIC8; Cytochrome P450 family 2 subfamily C polypeptide 8; Cytochrome P450 form 1; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 8; Flavoprotein linked monooxygenase; Microsomal monooxygenase; MP 12/MP 20; P450 form 1; P450 IIC2; P450 MP 12/MP 20; S mephenytoin 4 hydroxylase; Xenobiotic monooxygenase; s-mephenytoin 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; MP-12/MP-20;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Cynomolgus
  • Human
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP2C8-120H Recombinant Human CYP2C8, GST-tagged Wheat Germ GST 1 a.a. - 490 a.a.
Human CYP2C8-11773H Recombinant Human CYP2C8, His-tagged E.coli His 142-490a.a.
Human CYP2C8-384H Recombinant Human CYP2C8 Insect Cell N/A
Human CYP2C8-7114HCL Recombinant Human CYP2C8 293 Cell Lysate HEK293 N/A
Human CYP2C8-2794H Recombinant Human CYP2C8 protein, His&Myc-tagged E.coli His&Myc 27-490aa
Human CYP2C8-14H Active Recombinant Human CYP2C8 Protein E.coli
Human CYP2C8-76H Active Recombinant Human CYP2C8 Protein E. coli
Human CYP2C8-109HF Recombinant Full Length Human CYP2C8 Protein In Vitro Cell Free System GST 1 a.a. - 490 a.a.
Cynomolgus CYP2C8-124C Active Recombinant Cynomolgus CYP2C8 Protein E. coli
Rhesus Macaque CYP2C8-1150R Recombinant Rhesus monkey CYP2C8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CYP2C8-975R-B Recombinant Rhesus Macaque CYP2C8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CYP2C8-975R Recombinant Rhesus Macaque CYP2C8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Kit-0895 CYP2C8 Green Screening Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CYP2C8 Related Articles

CYP2C8 involved in several pathways and played different roles in them. We selected most pathways CYP2C8 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismFAM213B;CYP2C8;PLA2G10;PTGR1;ALOX15B;ALOX12;PTGIS;PLA2G16;EPHX2
Biological oxidationsCYP3A7-CYP3AP1;Sult2a2;CYP27A1;ADH6;AHCY;CYP7A1;CYP4B1;GLYAT;CYP4T8
CYP2E1 reactionsCYP2C19;CYP2B6;CYP2D6;CYP2A7;CYP2E1;CYP2F1;CYP2C8;CYP2S1;CYP2A13
Chemical carcinogenesisSULT1A2;UGT1A1;CYP3A7-CYP3AP1;GSTT2;ADH5;CCBL2;CYP2C39;ADH6;UGT1A6A
Cytochrome P450 - arranged by substrate typeCYP2S1;CYP24A1;CYP2A13;CYP3C1;CYP2C18;CYP4F22;CYP51A1;CYP2B6;CYP11B1
Drug metabolism - cytochrome P450ADH5;ADH6;CYP2C8;CYP2E1;ADH4;GSTK1;ADH7;CYP2C9;CYP2D6
Linoleic acid metabolismPLA2G4A;PLA2G4C;PLA2G10;CYP2P7;CYP3A25;PLA2G4D;CYP2C19;PLB1;CYP2J6
Metabolic pathwaysALOX12E;MGAT1;HSD17B3;FBP1B;A4GALT;HMGCR;PNP;PIP5K1A;CYCS

CYP2C8 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C8 itself. We selected most functions CYP2C8 had, and list some proteins which have the same functions with CYP2C8. You can find most of the proteins on our site.

Function Related Protein
(R)-limonene 6-monooxygenase activityCYP2C19;CYP2C9;CYP2C8
(S)-limonene 6-monooxygenase activityCYP2C9;CYP2C8;CYP2C19
(S)-limonene 7-monooxygenase activityCYP2C19;CYP2C9;CYP2C8
arachidonic acid epoxygenase activityCYP2D26;CYP2AA3;CYP2B19;CYP2C54;CYP2F1;CYP2AA12;CYP2C8;CYP2B6;CYP4F12
enzyme bindingMDM2;MAT2B;CYP1A2;PYCARD;ZFHX3;BIRC5;Il6ra;TOP2A;EIF4E
heme bindingCYP27B1;HBB-B2;CYP20A1;FAM84B;CYP2C37;CYB5D2;SDHDB;TDO2;CYP2A4
iron ion bindingCYP2C70;CYP2K17;CYP2C50;CYP4F12;FTL;HBBE2;CYP3A43;SLC11A2;CYP21A2
monooxygenase activityCYP2K6;CYP2N13;CYP2B19;TH2;CYP2AD3;CYP4F3;CYP2P9;CYP2AA9;TYR
oxidoreductase activitySC4MOL;CYP2P8;OXNAD1;IYD;DEGS2;GDI2;LOXL2B;DEGS1;AOX4
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCYP2P7;CYP2AA2;CYP2D26;CYP2C39;CYP2K6;CYP2F1;CYP2S1;CYP2C38;CYP1D1
oxygen bindingCYP2X8;CYP2B6;CYP4B1;CYP2A6;HBZ;CYP19A1;CYP2X7;CYP3A5;HBQ1
steroid hydroxylase activityCYP2D10;CYP2K18;CYP2AA7;CYP2AA4;CYP2K17;CYP2J6;CYP2AA9;CYP2A7;CYP2C9

CYP2C8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C8.

PGRMC1; A2M; APOE; DNAJB1; LONP1; BLMH; RIN3; MAST1; GABARAPL1; MAP1LC3A

Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).
Davis, JA; Rock, DA; et al. In Vitro Characterization of the Drug-Drug Interaction Potential of Catabolites of Antibody-Maytansinoid Conjugates. DRUG METABOLISM AND DISPOSITION 40:1927-1934(2012).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All CYP2C8 Products

Required fields are marked with *

My Review for All CYP2C8 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends