CYP2C9
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Official Full Name
cytochrome P450, family 2, subfamily C, polypeptide 9
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Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. -
Synonyms
CYP2C9; cytochrome P450, family 2, subfamily C, polypeptide 9; CPC9; CYP2C; CYP2C10; CYPIIC9; MGC88320; P450IIC9; MGC149605; cytochrome P450 2C9; OTTHUMP00000020135; cytochrome P-450MP; cytochrome P450 PB-1; microsomal monooxygenase; xenobiotic monooxygenase; flavoprotein-linked monooxygenase; cytochrome P-450 S-mephenytoin 4-hydroxylase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Cynomolgus
- Human
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- P.pastoris
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CYP2C9 Related Articles
CYP2C9 involved in several pathways and played different roles in them. We selected most pathways CYP2C9 participated on our site, such as Arachidonate Epoxygenase / Epoxide Hydrolase, Arachidonic acid metabolism, Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonate Epoxygenase / Epoxide Hydrolase | CYP2J2;CYP2C9;COX8A |
| Arachidonic acid metabolism | ALOX8;GGTLC1;ALOX5B.2;PLA2G4F;PLA2G4AA;PLA2G16;FAAH2A;PLA2G12A;CYP2AD6 |
| Biological oxidations | CYP4F12;ACY3;CYP17A1;SULT1ST5;ADH8B;ACY3.2;GLYATL1;UGT1B2;CYP24A1 |
| CYP2E1 reactions | CYP2C19;CYP2C8;CYP2A13;CYP2A6;CYP2C9;CYP2S1;CYP2B6;CYP2F1;CYP2E1 |
| Chemical carcinogenesis | PTGS2;CCBL2;GSTP1;CYP2A6;NAT2;MGST1;FAM84B;CYP3A7-CYP3AP1;SULT1A4 |
| Cytochrome P450 - arranged by substrate type | CYP2C19;CYP24A1;CYP19A1;CYP2AD2;CYP27A1;CYP2K6;CYP2E1;CYP3A5;CYP3A7 |
| Drug metabolism - cytochrome P450 | ADH5;GSTK1;GSTO2;CYP2C9;ADH2-2;CYP2A6;ADH2-1;CYP2B6;ADH6 |
| Linoleic acid metabolism | CYP2C45;CYP3A41A;CYP2C39;CYP2C19;PLA2G2D;PLA2G2F;CYP2J5;CYP2P7;PLA2G4A |
CYP2C9 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C9 itself. We selected most functions CYP2C9 had, and list some proteins which have the same functions with CYP2C9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| (R)-limonene 6-monooxygenase activity | CYP2C8;CYP2C9;CYP2C19 |
| (S)-limonene 6-monooxygenase activity | CYP2C9;CYP2C8;CYP2C19 |
| (S)-limonene 7-monooxygenase activity | CYP2C19;CYP2C8;CYP2C9 |
| arachidonic acid epoxygenase activity | CYP2A7;CYP4F2;CYP2D6;CYP2C9;CYP4F18;CYP2AA4;CYP2AA2;CYP2C19;CYP2F2 |
| aromatase activity | CYP4X1;CYP4Z1;CYP1B1;CYP2B19;CYP1A4;CYP2H1;CYP2D9;CYP4A12A;CYP2A13 |
| caffeine oxidase activity | CYP3A4;CYP2C9;CYP2C38;CYP1A2;FAM84B;CYP2C39 |
| drug binding | GABRA1;MT3;GSTP2;ADH1;FOLR2;ADRB2;CNR1;DRD4;TYMS |
| heme binding | IRGM1;SDHDB;HBB-BH1;CYP4F11;CYP2AA7;CYP21A1;NOX4;CYP21A2;CYP3C1L2 |
| iron ion binding | CYP19A1A;CYP2X8;CYP2P8;HBAD;CYP2K16;CYGB1;TYW1;CYP2H1;CYP4F2 |
| monooxygenase activity | CYP2P9;CYP2AA1;CYP2X10.2;CYP2C37;CYP2C39;CYP4A12A;MOXD1L;CYP20A1;CYP2P7 |
| oxidoreductase activity | JMJD1C;MOXD1L;ALDH9A1B;F8;CYP2P10;RDH8B;CYP2F2;HSD17B6;HMGCRA |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2P6;CYP2F1;CYP2AA1;CYP2AD6;CYP2C55;CYP2A4;CYP3A25;CYP2J6;CYP2X10.2 |
| oxygen binding | XGB;CYP26A1;CYP2C50;FAM84B;HBD;CYP2P10;HBBE3;CYP2R1;CYP2F2 |
| steroid hydroxylase activity | CYP2D10;CYP2C38;CYP2K18;CYP2AA12;CYP2X7;CYP2AA3;CYP2N13;CYP2J6;CYP2K22 |
CYP2C9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C9 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C9.
STAMBP; RAB3D; STAT5A; CDC37; RNF32; MAST1
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