CYP2E1
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Official Full Name
cytochrome P450, family 2, subfamily E, polypeptide 1
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Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008] -
Synonyms
CYP2E1; cytochrome P450, family 2, subfamily E, polypeptide 1; CPE1; CYP2E; P450-J; P450C2E; cytochrome P450 2E1; CYPIIE1; cytochrome P450-J; microsomal monooxygenase; xenobiotic monooxygenase; 4-nitrophenol 2-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Human
- Human and Yeast
- Mouse
- Pig
- Rat
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- S.cerevisiae
- Wheat Germ
- Yeast
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- CYP2E1 Related Articles
CYP2E1 involved in several pathways and played different roles in them. We selected most pathways CYP2E1 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2E1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Arachidonic acid metabolism | GGT1;CYP2C70;GGT5;CYP2AD6;CYP2AD3;ALOX15;FAM213B;CYP4F14;AKR1C21 |
Biological oxidations | CYP3C1;ACY3.1;GGTLC1;ADH7;CYP2Y3;CES1;SLC26A2;SLC26A1;CYP2A7 |
CYP2E1 reactions | CYP2E1;CYP2C9;CYP2A6;CYP2C19;CYP2D6;CYP2A7;CYP2A13;CYP2C8;CYP2S1 |
Chemical carcinogenesis | SULT1A2;CYP3A43;AKR1C2;CYP2C37;ALDH3B2;ALDH3A1;NAT1;SULT1A3;ADH5 |
Cytochrome P450 - arranged by substrate type | CYP4B1;CYP4A11;CYP2AD3;CYP3A7;CYP2A13;CYP17A1;CYP46A1;CYP11A1;CYP2K18 |
Drug metabolism - cytochrome P450 | ADH5;ADH7;CYP2C8;CYP3A5;CYP2D6;ADH4;ADH1A;CYP2A6;ADH1C |
Fatty Acid Omega Oxidation | ADH1C;ADH7;ADH6;CYP2A6;ADH4;CYP1A1;ADH1B;CYP4A11;CYP2D6 |
Folate-Alcohol and Cancer Pathway | CYP2E1;ALDH1L1 |
CYP2E1 has several biochemical functions, for example, arachidonic acid epoxygenase activity, enzyme binding, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2E1 itself. We selected most functions CYP2E1 had, and list some proteins which have the same functions with CYP2E1. You can find most of the proteins on our site.
Function | Related Protein |
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arachidonic acid epoxygenase activity | CYP2P9;CYP2D6;CYP4A11;CYP2P8;CYP2S1;CYP2C9;CYP2AA8;CYP2C70;CYP2P7 |
enzyme binding | H2AFX;TSPAN33;CABYR;PTEN;ACAT1;SRC;ADORA2A;HSPA8;USP22 |
heme binding | CYP2B19;CYP2C50;CYP2AA9;CYB5D2;CYP1D1;CYP26C1;CYP46A1.4;CYP2AD3;SRC |
iron ion binding | CYP20A1;CYP4A10;CYP46A1.1;ALOX12;NOS2B;HBA-X;NOS2A;CYP3A4;CYP3A7 |
monooxygenase activity | CYP4F18;CYP3C4;CYP2X7;CYP4V2;TYR;COQ6;MICAL2B;TH2;CYP26C1 |
oxidoreductase activity | CBR1L;OSGIN2;ETFA;CYP2X7;SC5D;KDM1A;RETSAT;IYD;CYP2E1 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | POR;CYP2E1;MICAL2;MICAL1;NDOR1;CYP11C1;CYP11B1;CYP4F2;COQ6 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2A7;CYP2C18;CYP2B19;CYP1D1;CYP3A25;CYP2K6;CYP2D26;CYP2R1;CYP2E1 |
oxygen binding | CYP2F2;CYP2J6;CYP26A1;CYP2D26;CYP2S1;HBB-BH1;CYP2Y3;HBA2;CYP3A7 |
steroid hydroxylase activity | CYP2E1;CYP2P9;CYP2J2;CYP2AD3;CYP2AA12;CYP2C9;CYP2AA9;CYP2C38;CYP2D26 |
CYP2E1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2E1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2E1.
MAFG; CLU; PTN; ECHS1; RPL13A; GATM; NMI; ABCA5; AGXT2; LAMC3
- Q&As
- Reviews
Q&As (7)
Ask a questionGenetic polymorphisms in CYP2E1 can result in altered enzyme activity, influencing an individual's response to drugs and susceptibility to liver damage.
CYP2E1 oxidizes and metabolizes various small molecules, including drugs and toxins.
It plays a significant role in ethanol metabolism and helps detoxify industrial solvents and other xenobiotics.
Ethanol, fasting, and certain drugs can induce the expression of CYP2E1.
CYP2E1 activity generates ROS, contributing to oxidative stress and potential cellular damage.
CYP2E1 is highly expressed in the liver, which is the main site for drug metabolism.
CYP2E1 can contribute to drug-drug interactions, affecting the efficacy and toxicity of co-administered drugs.
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