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CYP2J2

Official Full Name

cytochrome P450, family 2, subfamily J, polypeptide 2
Overview

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. [provided by RefSeq, Jul 2008]
Synonyms

CYP2J2; cytochrome P450, family 2, subfamily J, polypeptide 2; CPJ2; cytochrome P450 2J2; CYPIIJ2; microsomal monooxygenase; arachidonic acid epoxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	CYP2J2-2268H	Recombinant Human CYP2J2 Protein, GST-tagged	Wheat Germ	GST	Inquiry
Human	CYP2J2-7110HCL	Recombinant Human CYP2J2 293 Cell Lysate	HEK293	N/A	Inquiry
Human	CYP2J2-47H	Active Recombinant Human CYP2J2 Protein	E.coli		Inquiry
Human	CYP2J2-80H	Recombinant Human CYP2J2 Protein	E. coli		Inquiry
	Kit-0914	CYP2J2 Cyan Screening Kit		N/A	Inquiry

Involved Pathway
Protein Function
Interacting Protein
CYP2J2 Related Articles

CYP2J2 involved in several pathways and played different roles in them. We selected most pathways CYP2J2 participated on our site, such as Arachidonate Epoxygenase / Epoxide Hydrolase, Arachidonic acid metabolism, Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2J2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Arachidonate Epoxygenase / Epoxide Hydrolase	CYP2J2;COX8A;CYP2C9
Arachidonic acid metabolism	CYP2C50;CBR3;CYP2B6;CYP2P8;GPX1A;PLA2G10;CBR1;PLA2G6;PTGES3
Biological oxidations	PAOX;CYP2K18;ADH5;ADH1C;ADH4;CYP26A1;PRKRA;DPEP2;CYP4T8
Cytochrome P450 - arranged by substrate type	CYP3C1;FAM84B;CYP3A5;CYP2AD6;CYP3A4;FDXR;CYP4F11;CYP7A1;CYP4T8
Fatty acids	CYP2V1;CYP4F12;CYP2B6;CYP2J2;CYP2AD6;CYP2A13;CYP4A11;CYP4B1;CYP2D6
Inflammatory mediator regulation of TRP channels	ASIC2;CYP4A10;ITPR1;F2RL1;PLCG2;MAP2K3;GNAQ;CAMK2B;PRKCH
Linoleic acid metabolism	CYP3A41B;PLA2G4A;PLA2G12B;CYP2C19;PLB1;PLA2G12A;PLA2G2F;DHRS13L1;PLA2G4D
Metabolic pathways	MTMR7B;CYP26A1;Akr1b3;IDI2;GLUD1B;AGPAT9L;ENO2;PI4KAA;AMDHD1

CYP2J2 has several biochemical functions, for example, arachidonic acid 11,12-epoxygenase activity, arachidonic acid 14,15-epoxygenase activity, arachidonic acid epoxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2J2 itself. We selected most functions CYP2J2 had, and list some proteins which have the same functions with CYP2J2. You can find most of the proteins on our site.

Function	Related Protein
arachidonic acid 11,12-epoxygenase activity	CYP2J2;CYP2J6
arachidonic acid 14,15-epoxygenase activity	CYP2J6;CYP2J2
arachidonic acid epoxygenase activity	CYP2P8;CYP2AA9;CYP4A10;CYP2P9;CYP2AA4;CYP2C55;CYP2AA12;CYP2AA2;CYP2E1
aromatase activity	CYP2A7;CYP2C38;CYP2D6;CYP4F12;CYP4A12A;CYP3A43;CYP1A4;CYP2F1;CYP2J6
heme binding	Adgb;HBD;HRG-1;SDHDB;CYP2F2;CYP4V2;SUOX;CYP2J5;CYP1A
iron ion binding	CYP39A1;CYP2AA8;CYP11C1;CYP2AD2;SC5DL;HBQ1;TYW1B;FDX1;ALOX5A
linoleic acid epoxygenase activity	CYP2J6;CYP2C50;CYP2C55;CYP2C54;CYP2J2
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2C38;CYP2J5;CYP2AA3;CYP2U1;CYP3C1;CYP2E1;CYP2AA9;CYP2F2;CYP1B1
oxygen binding	HBA2;CYP2B19;HBM;HBG1;HBE1;TDO2;CYP2Y3;CYP2AA2;CYP2C55
steroid hydroxylase activity	CYP2P10;CYP2J6;CYP2AA3;CYP2P8;CYP2P7;CYP2V1;CYP2C18;CYP1A1;FAM84B

CYP2J2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2J2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2J2.

ZBTB25; TCEB1

Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).

Uehara, S; Murayama, N; et al. Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. XENOBIOTICA 44:769-774(2014).