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CYP2R1

Official Full Name

cytochrome P450, family 2, subfamily R, polypeptide 1
Overview

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency.
Synonyms

CYP2R1; cytochrome P450, family 2, subfamily R, polypeptide 1; vitamin D 25-hydroxylase; Cytochrome P450 2R1; Cytochrome P450 family 2 R1; Cytochrome P450 family 2 subfamily R polypeptide 1; EC 1.14.13.15; MGC4663; Vitamin D 25 hydroxylase; OTTHUMP00000231476; cytochrome P450, family 2, R1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CYP2R1-2269H	Recombinant Human CYP2R1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CYP2R1-7109HCL	Recombinant Human CYP2R1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CYP2R1-2123H	Recombinant Human CYP2R1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CYP2R1-2393HF	Recombinant Full Length Human CYP2R1 Protein, GST-tagged	In Vitro Cell Free System	GST	501 amino acids	Inquiry
Mouse	Cyp2r1-2418M	Recombinant Mouse Cyp2r1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rhesus Macaque	CYP2R1-1156R	Recombinant Rhesus monkey CYP2R1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	CYP2R1-981R-B	Recombinant Rhesus Macaque CYP2R1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	CYP2R1-981R	Recombinant Rhesus Macaque CYP2R1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CYP2R1 involved in several pathways and played different roles in them. We selected most pathways CYP2R1 participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Biological oxidations	CYP2K17;CYP2K18;CYP4F11;ACY3;ADH7;CYP3A7-CYP3AP1;PAOX;CYP11B2;CYP2W1
Cytochrome P450 - arranged by substrate type	CYP2B6;CYP4F12;CYP4F22;CYP3A5;CYP4B1;FAM84B;CYP8B2;CYP46A1;CYP2C19
Metabolic pathways	PTGS1;GBA3;PLA2G10;NANSA;PAFAH1B1B;GLUD2;MINPP1;MBOAT1;GAL3ST1
Metabolism	UROC1;ARSI;CPNE3;DHCR24;HS3ST4;PROZA;PPM1L;ITPKA;PCBD1
Metabolism of lipids and lipoproteins	ACOT9;CYP46A1;CDS1;CYP2U1;ACOT9.1;FABP11A;GC;MED6;LBR
Metabolism of steroid hormones and vitamin D	AKR1B15;CYP27B1;PPP1R2;CYP2R1;CYP24A1;HSD17B11;GC;STARD5
Phase 1 - Functionalization of compounds	CYP2AD2;CYP2K22;CYP2K19;CYP26A1;CYP3C4;CYP8B2;CYP2AD3;CYP2S1;CYP2U1
Steroid biosynthesis	CYP2R1;CYP51;NSDHL;SQLEA;CPN1;SOAT2;SC5DL;EBP;SC4MOL

CYP2R1 has several biochemical functions, for example, heme binding, iron ion binding, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2R1 itself. We selected most functions CYP2R1 had, and list some proteins which have the same functions with CYP2R1. You can find most of the proteins on our site.

Function	Related Protein
heme binding	CYB5R4;NR1D1;CYP2B19;PTGESL;CYP8B3;CYP3A7;CYP3C1;CYP2AA1;HBB
iron ion binding	CYP2AD2;PPEF2;CYP19A1;PTGIS;CYP4Z1;HBM;ISCUB;HBB-Y;CYP2AA4
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP19A1;CYP2J2;CYP2AA4;CYP2K22;CYP2X9;CYP2D6;CYP2Y3;CYP2K18;CYP2A7
oxygen binding	CYP2K19;CYP2N13;CBS;CYP3A5;HBAE3;TH;HBE1;CYP1B1;Adgb
steroid hydroxylase activity	CYP2AA9;CYP2AA1;CYP2D9;CYP46A1.3;CYP2N13;CYP2K22;CYP2P8;CYP1A1;CYP2AD2
vitamin D3 25-hydroxylase activity	CYP3A4;CYP27A1;CYP2R1;FAM84B

CYP2R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2R1.