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CYP3A4

  • Official Full Name

    cytochrome P450, family 3, subfamily A, polypeptide 4

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    CYP3A4; cytochrome P450, family 3, subfamily A, polypeptide 4; HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1; MGC126680; cytochrome P450 3A4; OTTHUMP00000210308; cytochrome P450 3A3; cytochrome P450 HLp; cytochrome P450-PCN1; cytochrome P450 NF-25; quinine 3-monooxygenase; albendazole monooxygenase; P450-III, steroid inducible; glucocorticoid-inducible P450; taurochenodeoxycholate 6-alpha-hydroxylase; cytochrome P450, subfamily IIIA, polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Cynomolgus
  • Homo sapiens (Human)
  • Human
  • Rhesus Macaque
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • P.pastoris
  • S.cerevisiae
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP3A4-549H Active Recombinant Human CYP3A4 S.cerevisiae N/A
Human CYP3A4-548H Active Recombinant Human CYP3A4 E.coli N/A
Human CYP3A4-18H Recombinant Human CYP3A4 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CYP3A4-540H Recombinant Human CYP3A4 Insect Cell N/A
Human CYP3A4-33H Recombinant Human CYP3A4/NADPH reductase protein P.pastoris N/A
Human CYP3A4-26688TH Recombinant Human CYP3A4 Wheat Germ N/A 503 amino acids
Human CYP3A4-11784H Recombinant Human CYP3A4, His-tagged E.coli His 154-503a.a.
Human CYP3A4-2273H Recombinant Human CYP3A4 Protein, GST-tagged Wheat Germ GST
Human CYP3A4-436HCL Recombinant Human CYP3A4 cell lysate N/A
Human CYP3A4-347H Active Recombinant Human CYP3A4 Protein E.coli
Human CYP3A4-545H Recombinant Human CYP3A4 Full Length Transmembrane protein (Ala2-Ala503), His-tagged In vitro E. coli expression system His 2-503aa
Human CYP3A4-5369H Recombinant Human CYP3A4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CYP3A4-2433HF Recombinant Full Length Human CYP3A4 Protein, GST-tagged In Vitro Cell Free System GST 503 amino acids
Human CYP3A4-1301H Recombinant Human CYP3A4 Protein, His-tagged E.coli N-His Pro344-Asp497
Human CYP3A4-81H Active Recombinant Human CYP3A4 Protein E. coli
Human CYP3A4-117HF Recombinant Full Length Human CYP3A4 Protein In Vitro Cell Free System 503 amino acids
Human CYP3A4-7592HFL Recombinant Full Length Human CYP3A4 protein, Flag-tagged Mamanlian cells Flag
Human CYP3A4-1905H Recombinant Human CYP3A4 Protein (Gly26-Ala503), N-His tagged E.coli N-His Gly26-Ala503
Cynomolgus CYP3A4-128C Active Recombinant Cynomolgus CYP3A4 Protein E. coli
Homo sapiens (Human) RFL25689HF Recombinant Full Length Human Cytochrome P450 3A4(Cyp3A4) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-503)
Rhesus Macaque CYP3A4-1158R Recombinant Rhesus monkey CYP3A4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CYP3A4-983R-B Recombinant Rhesus Macaque CYP3A4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CYP3A4-983R Recombinant Rhesus Macaque CYP3A4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Kit-0920 CYP3A4 Blue Screening Kit N/A
Kit-1918 Cytochrome P450 3A4 (CYP3A4) Activity Assay Kit N/A
Kit-0907 CYP3A4 Green Screening Kit N/A
Kit-2142 Cytochrome P450 3A4 Inhibitor Screening Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CYP3A4 Related Articles

CYP3A4 involved in several pathways and played different roles in them. We selected most pathways CYP3A4 participated on our site, such as Aflatoxin B1 metabolism, Aflatoxin activation and detoxification, Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Aflatoxin B1 metabolismPRKRA;CYP3A4;CYP1A2;FAM84B;CYP2A13
Aflatoxin activation and detoxificationPRKRA;GGT6;CYP3C1;ACY3;CYP3A4;CYP3A5;CYP1A2;ACY3.1;DPEP1
Benzo(a)pyrene metabolismCYP1A1;AKR1A1;AKR1C2;AKR1C4;FAM84B;CYP3A4;CYP1B1
Bile secretionSLC22A7;CYP3A4;SLC2A1;NCEH1;ATP1B2;PRKACB;SLCO1A2;RXRA;SULT2A1
Biological oxidationsBPNT1;UGT1B1;MTRR;SLC35B2;SULT2ST1;AKR1A1;CYP11B1;CYP8B2;UGT1B2
Chemical carcinogenesisCYP2C37;CYP3A5;AHA-1;PTGS2;GSTT2;ADH1;CCBL1;CYP2C54;EPHX1
Cytochrome P450 - arranged by substrate typeCYP1A1;CYP2Y3;CYP3A5;CYP2AD3;CYP3A7;CYP4F11;CYP4B1;CYP2A7;CYP11A1

CYP3A4 has several biochemical functions, for example, aromatase activity, caffeine oxidase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A4 itself. We selected most functions CYP3A4 had, and list some proteins which have the same functions with CYP3A4. You can find most of the proteins on our site.

Function Related Protein
aromatase activityCYP2C55;CYP2C9;CYP2A12;CYP4Z1;CYP2C18;FAM84B;CYP2C54;CYP1B1;CYP2J5
caffeine oxidase activityCYP2C9;CYP1A2;CYP2C39;FAM84B;CYP3A4;CYP2C38
enzyme bindingHSPA1B;CYP3A4;PUS7;PICK1;MAPK8;PPP1R3B;DNMT3L;SELS;GSTM4
heme bindingCYP2C19;NGB;CYP2AA12;CYP2K19;HBB;CYP27C1;CBSA;CYP2J2;CYP46A1.1
iron ion bindingTPH1B;CYP4V7;CYP2K18;CYP2AA8;CYP2C55;HBQ1;CYP2K22;ALOX12;CYP46A1.3
monooxygenase activityCYP3A5;CYP2X8;CYP4A12A;TYR;CYP2P7;CYP19A1B;FOXRED2;CYP2C70;CYP2Y3
oxidoreductase activityGFOD2;HSDL1;CYP2C55;WWOX;DHRS12;SC5D;KDM1B;CYP2A12;PDPR
oxygen bindingCYP2K6;HBA1;CBS;CYP2D6;CYP2C54;HBZ;HBAD;Adgb;CYP2A4
quinine 3-monooxygenase activityFAM84B;CYP3A4
steroid bindingAKR1D1;ESRRG;HSD17B10;CYP21A2;PAQR7;HSD3B4;ESRRGB;FAM84B;PAQR5B
steroid hydroxylase activityCYP2K22;CYP2J6;CYP2U1;CYP2C9;CYP2AA2;CYP2AA3;CYP2C38;CYP2C50;CYP2F2
taurochenodeoxycholate 6alpha-hydroxylase activityCYP3A4;FAM84B
testosterone 6-beta-hydroxylase activityFAM84B;CYP3A41B;CYP3A25;CYP3A41A;CYP3A4
vitamin D 24-hydroxylase activityCYP1A1;CYP3A4;FAM84B
vitamin D3 25-hydroxylase activityCYP27A1;CYP2R1;FAM84B;CYP3A4

CYP3A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP3A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP3A4.

PGRMC1; GK

Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
Czerwinski, M; Kazmi, F; et al. Anti-CD28 Monoclonal Antibody-Stimulated Cytokines Released from Blood Suppress CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes In Vitro. DRUG METABOLISM AND DISPOSITION 43:42-52(2015).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does CYP3A4 contribute to inter-individual drug response variability? 02/13/2022

Variability in CYP3A4 activity due to genetic, environmental, and health factors results in diverse drug responses among individuals.

What is the impact of CYP3A4 inhibitors and inducers on drug effectiveness and safety? 01/07/2020

CYP3A4 inhibitors can increase, while inducers can decrease drug levels, affecting their safety and effectiveness.

Where is CYP3A4 most highly expressed? 09/09/2019

CYP3A4 is predominantly expressed in the liver and intestines.

What role does CYP3A4 play in drug metabolism? 04/03/2019

CYP3A4 is crucial for breaking down and clearing a wide variety of drugs and toxins from the body.

Are there common genetic polymorphisms in CYP3A4, and how do they affect enzyme activity? 01/23/2019

Genetic polymorphisms in CYP3A4 can result in altered enzyme activity, impacting drug metabolism.

How can CYP3A4-mediated drug interactions be managed? 01/02/2019

Managing CYP3A4-mediated interactions may involve using drug interaction databases, adjusting drug dosages, or choosing alternative medications.

How does CYP3A4 activity vary with age? 01/18/2018

CYP3A4 activity is generally lower in infants, peaks in childhood, and varies in adults.

Customer Reviews (3)

Write a review
Reviews
09/06/2021

    Superior quality, highly recommend.

    01/23/2020

      Worked well, as described.

      01/08/2020

        Perfect for protein studies.

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