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CYP3A43

Official Full Name

cytochrome P450, family 3, subfamily A, polypeptide 43
Overview

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms.
Synonyms

CYP3A43; cytochrome P450, family 3, subfamily A, polypeptide 43; cytochrome P450, subfamily IIIA, polypeptide 43; cytochrome P450 3A43; Cytochrome P450 family 3 subfamily A polypeptide 43; Cytochrome P450 polypeptide 43; Cytochrome P450 subfamily IIIA polypeptide 43; MGC119315; MGC119316;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CYP3A43-2275H	Recombinant Human CYP3A43 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CYP3A43-437HCL	Recombinant Human CYP3A43 cell lysate		N/A		Inquiry
Human	CYP3A43-2434HF	Recombinant Full Length Human CYP3A43 Protein, GST-tagged	In Vitro Cell Free System	GST	280 amino acids	Inquiry
Rhesus Macaque	CYP3A43-1159R	Recombinant Rhesus monkey CYP3A43 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	CYP3A43-984R	Recombinant Rhesus Macaque CYP3A43 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	CYP3A43-984R-B	Recombinant Rhesus Macaque CYP3A43 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

CYP3A43 involved in several pathways and played different roles in them. We selected most pathways CYP3A43 participated on our site, such as Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A43 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chemical carcinogenesis	GSTK1;SULT2A1;UGT2A1;CYP3A41A;Nat3;GSTT1;CBR1;SULT1A3;PTGS2

CYP3A43 has several biochemical functions, for example, aromatase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A43 itself. We selected most functions CYP3A43 had, and list some proteins which have the same functions with CYP3A43. You can find most of the proteins on our site.

Function	Related Protein
aromatase activity	CYP2J5;CYP1A4;CYP2H1;CYP2D26;CYP4Z1;CYP2J2;CYP2C37;CYP3A4;CYP1D1
heme binding	HBB;CYP2A7;HBB-Y;PTGS2B;HBZ;CYP27A1;CYP4V2;TDO2B;CYP2C18
iron ion binding	CYP4F18;JMJD6;NOS2A;CYP2B19;CYP2AA9;CYP4X1;OGFOD2;CYP51A1;HBA-X
monooxygenase activity	CYP11C1;CYP2D6;CYP2P8;CYP2P7;CYP21A1;CYP2AA7;CYP46A1.2;PTGIS;CYP2E1

CYP3A43 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP3A43 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP3A43.