CYP4F12
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Official Full Name
cytochrome P450, family 4, subfamily F, polypeptide 12
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Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid; however, its physiological function has not been determined. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. -
Synonyms
CYP4F12; cytochrome P450, family 4, subfamily F, polypeptide 12; cytochrome P450, subfamily IVF, polypeptide 12; cytochrome P450 4F12; CYPIVF12; F22329_1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Homo sapiens (Human)
- Human
- Rhesus Macaque
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CYP4F12 Related Articles
CYP4F12 involved in several pathways and played different roles in them. We selected most pathways CYP4F12 participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Eicosanoids, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4F12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biological oxidations | NAT2;UGT1B5;CYP2U1;GLYATL2;CYP2W1;PAOX;AADAC;CYP1A1;Sult2a2 |
| Cytochrome P450 - arranged by substrate type | CYP7A1;CYP4F22;FDXR;CYP21A2;CYP2B6;CYP3A7;CYP3A7-CYP3AP1;CYP2F1;CYP19A1 |
| Eicosanoids | CYP4F11;CYP4F22;CYP4F12;CYP4B1;CYP4A11 |
| Fatty acids | CYP4F11;CYP4T8;CYP2J2;CYP4A11;CYP4F22;CYP2AD6;CYP2A7;CYP2F1;CYP2N13 |
| Metabolism | CSNK1G2;Alb;SPTLC1;COX16;ATP5L;CYP4F11;MED9;CBLC-1;UGT1B1 |
| Phase 1 - Functionalization of compounds | CYP3C4;CYP2AD6;ADH8B;CYP2U1;CYP27B1;CYP2R1;CYP2K8;CYP2K18;CYP46A1 |
| Tryptophan metabolism | AOX2P;ACAT2;INMT;ALDH2.1;CYP4F12;ALDH2;ASMT;HADH;GCDHB |
| cytochrome P450 | CYP2W1;CYP4F12;CYP20A1;CYP4V2;CYB5R3;CYP2A7;CYP4Z1;CYB5A;CYB5B |
CYP4F12 has several biochemical functions, for example, alkane 1-monooxygenase activity, arachidonic acid epoxygenase activity, aromatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4F12 itself. We selected most functions CYP4F12 had, and list some proteins which have the same functions with CYP4F12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alkane 1-monooxygenase activity | CYP4F12;CYP4A12A;CYP4A11;CYP4A14;CYP4F2;CYP4F18;CYP4A10 |
| arachidonic acid epoxygenase activity | CYP2AD2;CYP2P7;CYP2D6;CYP2C18;CYP2B6;CYP2A4;CYP2AD6;CYP2F1;CYP2D10 |
| aromatase activity | CYP3A4;CYP2C50;CYP2C18;CYP2A7;CYP1A;CYP1D1;CYP2F1;CYP2D9;CYP4X1 |
| heme binding | SDHD;CYP21A2;CYP2K18;HBA2;CYP4F3;CYP27B1;CYP2C38;CYP4F12;PTGS1 |
| iron ion binding | PPEF1;PHF8;P4HA2;CYP4A12A;CYP46A1.1;CYP2N13;PAH;CYP46A1.4;CYP46A1.3 |
| leukotriene-B4 20-monooxygenase activity | CYP4A10;CYP4F3;CYP4F14;CYP4F2;CYP4F18;CYP4A11;CYP4F12 |
CYP4F12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4F12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4F12.
saicar; PKM; SOD2; HSPA6
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