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CYTH4

Official Full Name

cytohesin 4
Overview

The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The structures of this gene and CYTH1 are very similar.
Synonyms

CYTH4; cytohesin 4; pleckstrin homology, Sec7 and coiled coil domains 4 , pleckstrin homology, Sec7 and coiled/coil domains 4 , PSCD4; cytohesin-4; CYT4; AI467541; DJ63G5.1; FLJ00017; PH, SEC7 and coiled coil domain containing protein 4; Pleckstrin homology, SEC7, AND coiled coil domains protein 4; Pscd4; RGD1564842; pleckstrin homology, Sec7 and coiled-coil domains 4; pleckstrin homology, Sec7 and coiled/coil domains 4; PH, SEC7 and coiled-coil domain-containing protein 4;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
His|T7
Myc
DDK
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CYTH4-7158H	Recombinant Human CYTH4 protein, His & T7-tagged	E.coli	His/T7	Met1~Phe379 (Accession# Q9UIA0)	Inquiry
Human	CYTH4-7093HCL	Recombinant Human CYTH4 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CYTH4-4069H	Recombinant Human CYTH4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CYTH4-2090H	Recombinant Human CYTH4 Protein (Met1-Phe379), N-His tagged	E.coli	N-His	Met1-Phe379	Inquiry
Mouse	Cyth4-2431M	Recombinant Mouse Cyth4 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rhesus Macaque	CYTH4-1170R	Recombinant Rhesus monkey CYTH4 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	CYTH4-995R	Recombinant Rhesus Macaque CYTH4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	CYTH4-995R-B	Recombinant Rhesus Macaque CYTH4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	CYTH4-2043C	Recombinant Chicken CYTH4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CYTH4 involved in several pathways and played different roles in them. We selected most pathways CYTH4 participated on our site, such as Phospholipase D signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYTH4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phospholipase D signaling pathway	PDGFB;SHC3;PDGFC;PIK3CB;PDGFRA;PIP5K1B;Pdgfa&Pdgfb;PIK3R5;PLA2G4A
Endocytosis	RAB22A;CHMP4A;RAB11A;ZFYVE9;ITCH;KIF5C;RAB7A;EPN3;RHOA

CYTH4 has several biochemical functions, for example, ARF guanyl-nucleotide exchange factor activity, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYTH4 itself. We selected most functions CYTH4 had, and list some proteins which have the same functions with CYTH4. You can find most of the proteins on our site.

Function	Related Protein
ARF guanyl-nucleotide exchange factor activity	PSD4;FBXO8;CYTH4B;CYTH1B;CYTH3;CYTH1A;ARFGEF2;PSD3;IQSEC1
lipid binding	CYTH1;ACBD7;DLC1;ACBD5A;SH3GL1;FAM123C;PLUNC;RUFY1;PACSIN1B

CYTH4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYTH4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYTH4.