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Casp3

  • Official Full Name

    caspase 3, apoptosis-related cysteine peptidase

  • Overview

    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
  • Synonyms

    CASP3; caspase 3, apoptosis-related cysteine peptidase; CPP32; SCA-1; CPP32B; Apopain; CPP-32; EC 3.4.22.56; Yama; procaspase3; Cysteine protease CPP32; PARP cleavage protease; SREBP cleavage activity 1; Yama protein; caspase 3, apoptosis-related cysteine protease;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Others
  • Cattle
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Wheat Germ
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • His|MBP
  • His|T7
  • Met|His
  • MYC
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CASP3-192H Active Recombinant Human CASP3, Met&His-tagged E.coli Met/His
Human CASP3-1642H Active Recombinant Human CASP3, His-tagged E.coli His Ser29-His277
Human CASP3-158H Recombinant Human CASP3 E.coli N/A 176-277aa
Human CASP3-36H Recombinant Human CASP3, His-tagged E.coli His
Human CASP3-342H Recombinant Human CASP3, His tagged E.coli His
Human CASP3-334H Recombinant Human CASP3 protein, GST-tagged Human Wheat Germ GST
Human CASP3-622H Recombinant Human CASP3 protein, His & T7-tagged E.coli His/T7 Ser29~Asp175 (Accession # P42574)
Human CASP3-293H Recombinant Human CASP3 protein, His/MBP-tagged E.coli His/MBP 1-113 aa
Human CASP3-0421H Recombinant Human CASP3 Protein, GST-Tagged Wheat Germ GST
Human CASP3-621H Recombinant Human CASP3 protein, His-tagged E.coli His Ala183~His277
Human CASP3-7838HCL Recombinant Human CASP3 293 Cell Lysate HEK293 N/A
Human CASP3-7839HCL Recombinant Human CASP3 293 Cell Lysate HEK293 N/A
Human CASP3-01H Active Recombinant Human CASP3 Protein, His-tagged E.coli His 1-277
Human CASP3-188H Recombinant Human CASP3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CASP3-625H Recombinant Human CASP3 Protein, His-tagged E.coli N-His Ser29-His277
Human CASP3-1333H Recombinant Human CASP3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CASP3-2927HF Recombinant Full Length Human CASP3 Protein, GST-tagged In Vitro Cell Free System GST 277 amino acids
Human CASP3-946HFL Recombinant Full Length Human CASP3 Protein, C-Flag-tagged Mammalian cells Flag
Human CASP3-668HF Recombinant Full Length Human CASP3 Protein, GST-tagged In Vitro Cell Free System GST 277 amino acids
Human CASP3-624H Recombinant Human CASP3 Protein, His-tagged E.coli N-His Ser29-His277
Human CASP3-507H-B Recombinant Human CASP3 Protein Pre-coupled Magnetic Beads HEK293
Human CASP3-507H Recombinant Human CASP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CASP3-0594H Recombinant Human CASP3 Protein (M1-H277), Tag Free E.coli No tag M1-H277
Human CASP3-0595H Recombinant Human CASP3 Protein (M1-H277), His/Strep tagged E.coli His/Strep M1-H277
Mouse Casp3-1643M Active Recombinant Mouse Casp3 protein E.coli N/A
Mouse Casp3-1641M Recombinant Mouse Caspase 3 E.coli N/A
Mouse Casp3-623M Recombinant Mouse Casp3 protein, His-tagged E.coli His Ser29~Asp175
Mouse Casp3-771M Recombinant Mouse Casp3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Casp3-748R Recombinant Rat Caspase 3, His-tagged E.coli His
Rat Casp3-624R Recombinant Rat Casp3 protein, His & T7-tagged E.coli His/T7 Ser29~Asp175 (Accession # P55213)
Rat CASP3-1145R Recombinant Rat CASP3 Protein Mammalian Cell His
Rat Casp3-625R Recombinant Rat Casp3 protein, His & T7-tagged E.coli His/T7 Ala183~His277 (Accession # P55213)
Rat CASP3-803R-B Recombinant Rat CASP3 Protein Pre-coupled Magnetic Beads HEK293
Rat CASP3-803R Recombinant Rat CASP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cattle CASP3-623C Recombinant Cattle CASP3 Protein, His-tagged E.coli N-His Ser29-Asp175
Cynomolgus Monkey CASP3-362C Recombinant Cynomolgus CASP3 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CASP3-110C Recombinant Cynomolgus Monkey CASP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CASP3-110C-B Recombinant Cynomolgus Monkey CASP3 Protein Pre-coupled Magnetic Beads HEK293
Chicken CASP3-6290C Recombinant Chicken CASP3 Mammalian Cell His
CBCRY39 Caspase-3 E.coli N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Casp3 Related Articles
  • Casp3 Related Signal Pathway

Casp3 involved in several pathways and played different roles in them. We selected most pathways Casp3 participated on our site, such as MAPK signaling pathway, p signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Casp3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayDUSP8A;RAP1B;PPP3R1B;FGF21;ARRB1;PPM1NA;NRAS;C11orf52;FGF13A
p signaling pathwayPTEN;PTENA;PMAIP1;CASP3B;PPM1DB;BID;GADD45B;CCNG1;CD82A
ApoptosisHMGB2A;IL1B2;VIML;DIABLO;CAPN2A;IRAK3;BIRC3;BCL2L11;CASP6
Natural killer cell mediated cytotoxicityICAM2;PLCG2;PPP3R1;VAV3;HLA-A;GRB2;SH2D1B;IFNA14;GM-CSF
TNF signaling pathwayPIK3R3;PIK3CG;IL6;TRADD;TRAF3;PIK3R5;PIK3R1;CFLAR;CXCL10
Serotonergic synapseGNG4;GNAI2;HTR3B;NRAS;SLC18A2;ALOX12E;GNG5;RAF1;CYP2C70
Non-alcoholic fatty liver disease (NAFLD)PRKAB1;NDUFS1;TNF;UQCRFS1;NDUFA6;MLXIPL;NDUFC1;NDUFB3;PIK3CA
Alzheimers diseaseNDUFS2;COX4I2;BACE2;ATP5J;NDUFB11;NDUFB10;COX7B;NDUFS5;NDUFA2
Parkinsons diseaseATP5B;COX7A2;ATP5D;COX6A2;UBA1;NDUFS3;Casp3;SLC25A4;NDUFB7
Amyotrophic lateral sclerosis (ALS)GRIA1;TOMM40;MAPK14;NOS1;CCS;CAT;GRIN2C;NEFH;BCL2L1
Huntingtons diseaseUQCRB;DNALC1;SOD2;CASP8;ATP5H;ITPR1;NDUFS8;DCTN1;SDHB
PertussisIRAK1;MAPK1;CALM4;ITGB1;MAPK9;TNF;IL1A;C5;IL12A
LegionellosisCR1;IL1B;HSPA1B;ITGB2L;NAIP6;SAR1B;IL18;HSPA6;TLR2
ToxoplasmosisIFNGR2;NFKBIB;BIRC8;SOCS1;TNFRSF1A;LAMA1;LAMB3;MAPK8;PIK3R2
AmoebiasisFN1;PRKACA;CD14;PIK3CA;COL3A1;IL1R2;GNAS;PIK3R5;COL1A2
TuberculosisNFKB1;FCGR3;FCGR3B;AKT1;TNFRSF1A;HLA-DRB4;ATP6V0C;CASP10;IRAK4
Hepatitis BCasp3;GRB2;IFNA17;Ifna15;IFNA21;MAP3K1;STAT2;TP53;IRF3
Herpes simplex infectionIfna15;NXF3;BMA2;PER1A;TAP2;PER2;HLA-DPA1;H2-Q10;PTPN11B
Pathways in cancerMTOR;FGF1;FGF22;BIRC5;MMP2;LPAR2;CBLC;GNA11;MAPK1
Viral carcinogenesisKAT2B;HDAC10;RBPJL;SND1;HIST1H2BJ;HIST1H4G;HNRNPK;HIST1H2BP;CREB3L1
Proteoglycans in cancerFZD3;WNT4;MMP9;PIK3CG;ARHGEF1;HIF1A;IGF1R;ITGA5;HOXD10
MicroRNAs in cancerSHC1;PDGFRB;PLAU;NOTCH1;KIF23;PIK3CA;PIM1;WNT3A;SOCS1
Colorectal cancerMSH3;ARAF;TGFB3;TGFBR2;KRAS;MAPK9;APC;MSH2;BAD
Viral myocarditisHLA-DRB4;SGCA;HLA-DOA;HLA-DMA;FYN;CCND1;HLA-E;HLA-A;HLA-DQA1

Casp3 has several biochemical functions, for example, aspartic-type endopeptidase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Casp3 itself. We selected most functions Casp3 had, and list some proteins which have the same functions with Casp3. You can find most of the proteins on our site.

Function Related Protein
aspartic-type endopeptidase activityNRIP2;PSEN2;SPPL2;REN;CNTNAP5A;PGC;ASPRV1;PGA5;NRIP3
cyclin-dependent protein serine/threonine kinase inhibitor activityCDKN1BB;CDKN2D;CDKN1B;KAT2B;HEXIM1;CDKN1D;CDKN2C;CDKN1C;INCA1
cysteine-type endopeptidase activityTINAG;CTSZ;SFRP1;CFLARA;USP16;CTS7;USP30;ATG4B;USP5
cysteine-type endopeptidase activity involved in apoptotic processCASP8;Casp3;CLC
cysteine-type endopeptidase activity involved in execution phase of apoptosisCASP7;CASP3A;CASP6L2;Casp3;CASP3B;CASP6;CASP6L1
cysteine-type peptidase activityCASP6L2;SENP7;CTSSA;USP9;CAPN3B;CAPN1B;CASPB;CASP3A;SENP7B
death receptor bindingTMBIM1;BID;Casp3;FASLG;Fasl;CFLAR;FEM1B;MYD88;PIDD1
hydrolase activityCTDNEP1B;HYAL6;PPTC7A;SACM1LA;CTSSB.1;PTPRNA;IHHB;FAM108B;ELA2
peptidase activityTMPRSS4A;PSMB8F;ADAMTS7;SPINT1A;MALT1;TRY;F2RL1.2;ADAMTS12;MMP14B
phospholipase A2 activator activityCasp3;PLAA
protease bindingTNFAIP3;TNFRSF10A;TP53;SERPINE1;BDKRB2;ADAMTS4;CAST;SERPINA1A;STIM1
protein bindingKIF5A;KAT8;BLOC1S2;DDX20;NDUFB11;GSTO1;PLA2G16;ZNF32;HIST1H2BB
protein complex bindingATM;GNB2;LRRC16A;PTPRF;AP2B1;PRKACA;INS2;CDK5RAP1;FGFR1

Casp3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Casp3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Casp3.

THAP11; Parp1; Hdgf; Pkm; Rps18; Acta2; Fam21; Nucks1; Htt

Accialini, P; Hernandez, SF; et al. A link between Notch and progesterone maintains the functionality of the rat corpus luteum. REPRODUCTION 149:1-10(2015).
Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
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