CDK7
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Official Full Name
cyclin-dependent kinase 7
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Overview
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. -
Synonyms
CAK1; MO15; STK1; CDKN7; p39MO15; CDK7; cyclin-dependent kinase 7; CAK; p39 Mo15; 39 KDa protein kinase; Cdk-activating kinase; kinase subunit of CAK; serine/threonine kinase stk1; cell division protein kinase 7; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; homolog of Xenopus MO15 Cdk-activating kinase; TFIIH basal transcription factor complex kinase subunit; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human
- In Vitro Cell Free System
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- DDK
- Flag
- GST
- GST|His
- His
- His (Fc)
- Avi
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CDK7 Related Articles
- CDK7 Related Research Area
CDK7 involved in several pathways and played different roles in them. We selected most pathways CDK7 participated on our site, such as B Cell Receptor Signaling Pathway, Basal transcription factors, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| B Cell Receptor Signaling Pathway | ARPC2;TTC6;MAP2K1;FCGR2B;PDPK1A;PIK3R1;ACTR3;MAPK1;PPP3CC |
| Basal transcription factors | TAF12;TAF7L;TBP;TAF1;GTF2E2;GTF2H3-2;ERCC3;GTF2F1;GTF2IRD1 |
| Cell Cycle | SSNA1;MCPH1;GMNN;CCND2;YWHAZ;PCM1;GINS4;RBBP4;GINS3 |
| Cell Cycle, Mitotic | WAPAL;CEP152;SPDL1;LIN52;ZWILCH;DYNC1H1;CCDC99;CSNK2A2;DULLARD |
| Cyclin A/B1 associated events during G2/M transition | CDK7;FOXM1 |
| Cyclin A:Cdk2-associated events at S phase entry | CDK7;MYCA;CKS1B |
| Cyclin D associated events in G1 | CDKN2C;CKS1B;CDK7;CDKN2B;CDKN2D;E2F4;PIANP |
CDK7 has several biochemical functions, for example, ATP binding, DNA-dependent ATPase activity, RNA polymerase II carboxy-terminal domain kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK7 itself. We selected most functions CDK7 had, and list some proteins which have the same functions with CDK7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CBWD1;UBA2;VARS2;ACSM2;DCAKD;CAMK1D;SUPV3L1;DNAJA3;MTHFD1B |
| DNA-dependent ATPase activity | MSH4;RAD51C;CHD6;TOP2A;XRCC3;MSH6;MSH3;DDX11;ERCC2 |
| RNA polymerase II carboxy-terminal domain kinase activity | CDK1;CDK12;CDK13;MAPK1;CDK8;CCNK;CDK7;CDK9 |
| androgen receptor binding | RAN;CALR;DAXX;NCOA1;PIAS1;KDM4C;KDM3A;TRIM68;PRKCB |
| cyclin-dependent protein serine/threonine kinase activity | CDK17;CDK15;MAK;CDK2;CDKL5;CDK8;CDK7;CDKL3;CDK5 |
| protein C-terminus binding | PIAS4;ATXN2;TRIM3;MSH2;COIL;HPCAL4;NCF2;ATF4;MID1IP1 |
| protein binding | MX2;CC10;DNAJC7;TFB1M;EIF1AX;MCC;POLE4;KRT2;CLIC3 |
| protein kinase activity | EPHB4B;MAPKAPK2A;RNASEL;LMTK2;HIPK3A;CAMK1GA;PDPK1A;MAPK14B;CDC42BPB |
| transcription coactivator activity | ARL2BP;TUBB3;ARNT;TAF6L;APEX1;HCFC1;JUP;SERTAD2;SMARCA4 |
CDK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK7.
CCNH; MNAT1; GTF2H5; Dlg4; SRPK2; SRPK1; HSP90AB1; E2F1; HLA-DQA1
- Q&As
- Reviews
Q&As (6)
Ask a questionAt present, some drugs have been developed to act on CDK7, including some small molecule inhibitors and antibody drugs. These drugs can inhibit the activity of CDK7 or regulate its expression, thereby treating diseases associated with aberrant expression of CDK7.
Therapeutic strategies for CDK7 include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against CDK7 to inhibit its aberrant activity in tumors, or the regulation of CDK7 expression through gene knockout or overexpression technologies.
The expression of CDK7 is affected by a variety of factors, including transcription factors, epigenetic modifications, and hormones. For example, the E2F transcription factor can promote the transcription of CDK7, while the histone methyltransferase EZH2 can regulate the cell cycle by inhibiting the transcription of CDK7.
Certain biomolecules can be used as molecular markers of CDK7, such as the mRNA or protein of CDK7 detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
The main role of CDK7 in the cell cycle is to activate CDK2 and CDK1, which in turn drive the cell from G1 to S phase and from G2 to M phase. It regulates cell cycle progression by phosphorylating a variety of substrates, including Rb protein and Wee1 kinase.
CDK7 activity can be detected by methods such as phosphowestern blotting, kinase activity assays, and cell cycle analysis. These methods can detect the phosphorylation level and cell cycle distribution of CDK7 to assess its activity status in cells.
Customer Reviews (3)
Write a reviewWe are very satisfied with the performance and quality of their products and will continue to buy them.
It has high catalysis, high safety and high expression level, which makes the experimental process more convenient and saves a lot of time for scientific research.
The fluorescence and absorption properties are very good.
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