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CLNS1A

Official Full Name

chloride channel, nucleotide-sensitive, 1A
Overview

This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6.
Synonyms

CLNS1A; chloride channel, nucleotide-sensitive, 1A; CLCI; methylosome subunit pICln; ICln; nucleotide sensitive 1A; Chloride channel; Chloride channel nucleotide sensitive 1A; Chloride channel regulatory protein; Chloride conductance regulatory protein ICln; Chloride ion current inducer protein; CLNS 1A; CLNS1B; I(Cln); ICLN_HUMAN; Reticulocyte pICln; OTTHUMP00000228612; OTTHUMP00000228613; OTTHUMP00000228614; OTTHUMP00000228843; OTTHUMP00000228845; reticulocyte protein ICln; chloride;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rat
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CLNS1A-360H	Recombinant Human chloride channel, nucleotide-sensitive, 1A, His-tagged	E.coli	His		Inquiry
Human	CLNS1A-27276TH	Recombinant Human CLNS1A, His-tagged	E.coli	His		Inquiry
Human	CLNS1A-1509H	Recombinant Human CLNS1A Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CLNS1A-7437HCL	Recombinant Human CLNS1A 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CLNS1A-3743H	Recombinant Human CLNS1A protein, GST-tagged	E.coli	GST	1-237 aa	$319 / 25ug
Human	CLNS1A-1885HF	Recombinant Full Length Human CLNS1A Protein, GST-tagged	In Vitro Cell Free System	GST	237 amino acids	Inquiry
Rat	CLNS1A-1458R	Recombinant Rat CLNS1A Protein	Mammalian Cell	His		Inquiry
Rat	CLNS1A-1116R	Recombinant Rat CLNS1A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	CLNS1A-1116R-B	Recombinant Rat CLNS1A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	CLNS1A-8993Z	Recombinant Zebrafish CLNS1A	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CLNS1A involved in several pathways and played different roles in them. We selected most pathways CLNS1A participated on our site, such as Gene Expression, Metabolism of non-coding RNA, RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLNS1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Gene Expression	EEF1D;SIN3B;CSTF2;NR2C2;ZNF764;ZNF557;ZNF614;LSM10;SUPT4H1
Metabolism of non-coding RNA	SNUPN;PEAK1;CLNS1A;WDR77;PRMT5;DDX20
RNA transport	RANGAP1;EIF2S2;SENP2;SUMO4;PABPC1L2A;FMR1;NUP214;BAT1;NXT1
snRNP Assembly	WDR77;DDX20;PEAK1;CLNS1A;SNUPN

CLNS1A has several biochemical functions, for example, poly(A) RNA binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLNS1A itself. We selected most functions CLNS1A had, and list some proteins which have the same functions with CLNS1A. You can find most of the proteins on our site.

Function	Related Protein
poly(A) RNA binding	PPHLN1;THRAP3;PATL1;HIST1H1C;SEC23IP;PNPT1;CDC42EP4;RBM10;HNRNPA1
protein binding	LXN;NID2;GUCY2C;TEX19.1;MYL12A;DRD3;RAB11FIP3;NUDT1;LRRC25
protein heterodimerization activity	UGT1A4;NPAS4;PPP3CB;H2BFWT;TENM1;INHBA;BAK1;TTR;CYBB

CLNS1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLNS1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CLNS1A.

SNRPD1; SNRPD2; SNRPD3