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CTSA

  • Official Full Name

    cathepsin A

  • Overview

    This gene encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity. Deficiencies in this gene are linked to multiple forms of galactosialidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    CTSA; cathepsin A; GSL, PPGB, protective protein for beta galactosidase (galactosialidosis); lysosomal protective protein; carboxypeptidase C; BETA GALACTOSIDASE PROTECTIVE PROTEIN; EC 3.4.16.5; Glactosialidosis; GLB2; Goldberg Syndrome; GSL; NEURAMINIDASE BETA GALACTOSIDASE EXPRESSION; NGBE; PPCA; PPGB; Protective protein for beta galactosidase; OTTHUMP00000031778; OTTHUMP00000031780; OTTHUMP00000031781; carboxypeptidase L; beta-galactosidase 2; protective protein cathepsin A; beta-galactosidase protective protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Dog
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CTSA-489H Recombinant Human CTSA Protein, His/GST-tagged E.coli His/GST Asp215~Met470
Human CTSA-895H Recombinant Human CTSA protein(Met1-Tyr480), His-tagged HEK293 C-His Met1-Tyr480
Human CTSA-3026HCL Recombinant Human CTSA cell lysate Human Cell N/A
Human CTSA-3374H Recombinant Human CTSA Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CTSA-1374H Recombinant Human CTSA Protein (Ala29-Tyr480), C-His tagged Mammalian cells C-His Ala29-Tyr480
Human CTSA-2152H Recombinant Human CTSA Protein (Asp215-Met470), N-GST tagged E.coli N-GST Asp215-Met470
Human CTSA-788H Recombinant Human CTSA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Ctsa-908M Recombinant Mouse Ctsa protein(Met1-Tyr474), His-tagged HEK293 C-His Met1-Tyr474
Mouse Ctsa-42M Recombinant Mouse Ctsa Protein, His-tagged Insect Cell His
Mouse Ctsa-490M Recombinant Mouse Ctsa Protein, His/GST-tagged E.coli His/GST Asp215~Met470
Mouse CTSA-2399MCL Recombinant Mouse CTSA cell lysate Human Cell N/A
Mouse Ctsa-2366M Recombinant Mouse Ctsa Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Ctsa-7309M Recombinant Mouse Ctsa Protein, His-tagged His 24-474
Rat Ctsa-492R Recombinant Rat Ctsa Protein, His/GST-tagged E.coli His/GST Ala151~Val394
Rat Ctsa-875R Recombinant Rat Ctsa Protein, His-tagged CHO N-His Ala42-Tyr493
Dog CTSA-488D Recombinant Dog CTSA Protein, His/GST-tagged E.coli His/GST Asp234~Leu494
Cattle CTSA-487C Recombinant Cattle CTSA Protein, His-tagged E.coli His Leu171~Lys417
Rhesus Macaque CTSA-1085R Recombinant Rhesus monkey CTSA Protein, His-tagged Mammalian Cell His
Rhesus Macaque CTSA-910R Recombinant Rhesus Macaque CTSA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CTSA-910R-B Recombinant Rhesus Macaque CTSA Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CTSA-10833Z Recombinant Zebrafish CTSA Mammalian Cell His
Pig CTSA-491P Recombinant Pig CTSA Protein, His/GST-tagged E.coli His/GST Asn244~Leu489
Pig CTSA-876P Recombinant Pig CTSA Protein, His-tagged CHO N-His Ala44-Tyr493
Chicken CTSA-3138C Recombinant Chicken CTSA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CTSA Related Research Area

CTSA involved in several pathways and played different roles in them. We selected most pathways CTSA participated on our site, such as Lysosome, Renin-angiotensin system, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
LysosomeTCIRG1;ATP6V1H;MANBA;AP1G2;PSAP;SUMF1;ATP6V0A1;DNASE2A;ATP6V0A4
Renin-angiotensin systemRen1;ANPEP;KLK1B1;KLK1B26;KLK1B9;LNPEP;CMA1;AGTR1B;ACE2

CTSA has several biochemical functions, for example, carboxypeptidase activity, enzyme activator activity, serine-type carboxypeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSA itself. We selected most functions CTSA had, and list some proteins which have the same functions with CTSA. You can find most of the proteins on our site.

Function Related Protein
carboxypeptidase activityCNDP1;AGBL4;PGCP;CPE;CPD;CPM;NAALAD2;AGBL1;BLMH
enzyme activator activitySFTPB;PRKCE;APOA5;GLC8;ARL1;DBF4;GTF3C4;GMFG;DCP1B
serine-type carboxypeptidase activitySENP2;CPE;PRCP;CPVL;CPM;CPD;SCPEP1;CTSA;CPZ

CTSA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSA here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSA.

CTNNBIP1; tktA; pepP; vacB; carB; pi3p; GABARAP; ELN; GABARAPL2; Bcas2; GABARAPL1; VAPA

  • Q&As
  • Reviews

Q&As (7)

Ask a question
Are there any post-translational modifications that regulate CTSA activity? 06/12/2022

Post-translational modifications of CTSA are not well-documented, requiring further research for comprehensive understanding.

How does CTSA influence cellular processes outside the lysosome? 04/04/2022

CTSA has roles in various cellular processes outside the lysosome, though these are less well understood compared to its lysosomal functions.

What is the significance of CTSA in the degradation of glycoproteins? 03/24/2022

CTSA is crucial for the catabolism of glycoproteins, aiding in the removal of terminal sugar moieties.

What therapeutic strategies are being explored to address deficiencies or dysfunctions in CTSA? 01/27/2022

Therapeutic strategies for CTSA-related disorders are in the early stages of development, with enzyme replacement therapy being a potential avenue.

How is CTSA dysfunction associated with Galactosialidosis? 04/28/2020

Dysfunction or deficiency in CTSA leads to Galactosialidosis, characterized by the accumulation of sialyloligosaccharides and glycoproteins in tissues.

How does CTSA contribute to the stability and activation of other lysosomal enzymes? 10/29/2019

It forms a complex with β-galactosidase and neuraminidase, preventing their premature degradation and facilitating their activation.

What is the primary function of CTSA in the lysosome? 10/07/2019

CTSA acts as a protective protein, ensuring the stability and proper function of other lysosomal enzymes.

Customer Reviews (3)

Write a review
Reviews
06/12/2022

    Product arrived quickly, undamaged.

    04/04/2022

      Great results, worth buying.

      01/27/2022

        Highly pure, excellent product.

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