Ctsb
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Official Full Name
cathepsin B
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Overview
Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. In humans, it is coded by the CTSB gene. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants encoding the same protein have been found for this gene. -
Synonyms
CTSB; cathepsin B; EC 3.4.22.1; CPSB; amyloid precursor protein secretase; Cathepsin B1; cysteine protease; APPS; EC 3.4.22; APP secretase; OTTHUMP00000116009; OTTHUMP00000229510; OTTHUMP00000229511; OTTHUMP00000229512; OTTHUMP00000229514; OTTHUMP00000229515; OTTHUMP00000229516;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bovine
- Branchiostoma belcheri tsingtauense
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Bovine Tissue
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human Liver
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Ctsb Related Research Area
Ctsb involved in several pathways and played different roles in them. We selected most pathways Ctsb participated on our site, such as Adaptive Immune System, Antigen processing and presentation, Assembly of collagen fibrils and other multimeric structures, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ctsb were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | RAPGEF4;EVL;CD200;STIM1B;SEC23A;TRIM69;FRS2;FGFR1B;KIF4 |
| Antigen processing and presentation | HLA-F;HLA-DQA1;HSPA4;PDIA3;HLA-A;RFXANK;HLA-DRB4;HLA-DQB1;HLA-C |
| Assembly of collagen fibrils and other multimeric structures | LOXL2;COL1A1;COL2A1;COL10A1A;ABHD1;COL8A1A;PCOLCE;PLEC;COL5A1 |
| Collagen degradation | ELANE;LOC100686744;MMP19;ADAM9;ADAM10;MMP8;COL15A1B;COL9A1;CTSD |
| Collagen formation | COL28A1A;COL28A1;COL5A3B;PRP;COL5A2;COL11A1B;SERPINH1B;BMP1B;DST |
| Degradation of the extracellular matrix | BSG;ADAM8A;CTSL1;FURINB;MMP13;ADAMTS5;CTSS;ELANE;MMP20 |
| Extracellular matrix organization | COL4A4;FBLN1;LEPREL2;ASPN;PCOLCE2;MGC174857;CTSLL;NID1;BGNA |
| Immune System | OASL;EIF4G2A;CFHL2;CSH1;TRIM3;EVL;DEFB103A;GAN;GBP1 |
Ctsb has several biochemical functions, for example, collagen binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ctsb itself. We selected most functions Ctsb had, and list some proteins which have the same functions with Ctsb. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| collagen binding | DDR1;PDGFB;MTAP1A;LRRC15;SMAD7;SPARC;SERPINH1;CTSS;ITGA1 |
| cysteine-type endopeptidase activity | CTSL.1;ATG4B;CASP3B;LGMN;CTSBB;CTSW;USP3;USP25;Ctsl |
| cysteine-type peptidase activity | CASPA;CASPB;CASP3A;OTUD7B;PGPEP1;CTSL1;CASP8L1;CLCA5;ZRANB1B |
| kininogen binding | CTSL2;Ctsl;C1QBP;CTSB |
| peptidase activity | METAP2B;METAP2A;CASP8;CTRC;FAM105B;THSD4;CAPN2L;IMMP2L;CPD |
| peptide binding | CLTA;GPR37L1;AVPR2L;NLN;ANPEPA;GNRHR1;AVPR2;LTA4H;RNPEPL1 |
| protein binding | AMBRA1;VARS2;MTA2;CA1;CDC5L;EVL;TIGIT;RPL22;KLF17 |
| protein self-association | SLC2A1;ZNF496;TP53;CTSC;SYP;CBR2;CCDC88C;AGA;EPB49 |
| proteoglycan binding | FCN2;CECR1A;UBE4A;THBS1;NID1;SLIT2;CTSL1;CECR1;COL5A1 |
Ctsb has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ctsb here. Most of them are supplied by our site. Hope this information will be useful for your research of Ctsb.
AMBP; MLH1; RGS2; ADAMTSL4; gag-pol; CSTA; SPHK1
- Q&As
- Reviews
Q&As (7)
Ask a questionCTSB affects extracellular matrix remodeling, relevant in joint diseases like osteoarthritis.
CTSB is implicated in neurodegenerative diseases, potentially contributing to protein aggregation and neuronal damage.
Variations in CTSB expression impact tissue repair processes and the development of fibrosis in various organs.
CTSB regulates apoptosis and cell survival, influencing cell fate decisions under stress or damage.
CTSB can influence cancer progression by modulating the tumor microenvironment and facilitating tumor cell invasion.
CTSB is involved in lysosomal protein degradation, essential for cellular waste disposal and recycling.
CTSB plays a role in inflammation, impacting immune cell function and inflammatory responses.
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Reliable protein crystallography, key for our structural biology research.
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