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CTSC

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Official Full Name
cathepsin C
Background
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
CTSC; cathepsin C; PALS, PLS; dipeptidyl peptidase 1; DPP1; AI047818; CATC; Cathepsin J; CPPI; Dipeptidyl transferase; DPP I; DPPI; EC 3.4.14.1; HMS; JP; JPD; MGC126959; PALS; PLS; dipeptidyl peptidase I; dipeptidyl-peptidase I; DPP-I
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Ctsc Related Articles
>> Wang, XW; Liu, Y; et al. Long-term change of disease behavior in Papillon-Lefevre syndrome: Seven years follow-up. EUROPEAN JOURNAL OF MEDICAL GENETICS 58:184-187(2015).
>> Gregersen, VR; Gustavsson, F; et al. Bovine chromosomal regions affecting rheological traits in rennet-induced skim milk gels. JOURNAL OF DAIRY SCIENCE 98:1261-1272(2015).

45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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