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CTSE

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Official Full Name
cathepsin E
Background
The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene.
Synonyms
CTSE; cathepsin E; CATE; CATE_HUMAN; Cathepsin E form II; Erythrocyte membrane aspartic proteinase; OTTHUMP00000034345; OTTHUMP00000034346; slow-moving proteinase
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Ctse Related Articles
>> Zhang, Q; Zhao, XZ; et al. Expression and purification of soluble human cystatin C in Escherichia coli with maltose-binding protein as a soluble partner. PROTEIN EXPRESSION AND PURIFICATION 104:14-19(2014).
>> Walker, E; Gopalakrishnan, R; et al. Microscopic Detection of Quenched Activity-Based Optical Imaging Probes Using an Antibody Detection System: Localizing Protease Activity. MOLECULAR IMAGING AND BIOLOGY 16:608-618(2014).

45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-097-1828
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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