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DAB1

  • Official Full Name

    disabled homolog 1

  • Overview

    The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function.;In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons;past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein;encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate;neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been;reported, but their full length nature has not been determined.
  • Synonyms

    DAB1; disabled homolog 1 (Drosophila); disabled (Drosophila) homolog 1; disabled homolog 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DAB1-2314H Recombinant Human DAB1 Protein, GST-tagged Wheat Germ GST
Human DAB1-7087HCL Recombinant Human DAB1 293 Cell Lysate HEK293 N/A
Human DAB1-2519HF Recombinant Full Length Human DAB1 Protein, GST-tagged In Vitro Cell Free System GST 553 amino acids
Human DAB1-2325H Recombinant Human DAB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse DAB1-4286M Recombinant Mouse DAB1 Protein Mammalian Cell His
Mouse Dab1-2445M Recombinant Mouse Dab1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DAB1-2191M Recombinant Mouse DAB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DAB1-2191M-B Recombinant Mouse DAB1 Protein Pre-coupled Magnetic Beads HEK293
Rat DAB1-1767R Recombinant Rat DAB1 Protein Mammalian Cell His
Rat Dab1-400R Recombinant Rat Dab1 Protein, His-tagged E.coli His Tyr42~Glu168
Rat DAB1-1425R-B Recombinant Rat DAB1 Protein Pre-coupled Magnetic Beads HEK293
Rat DAB1-1425R Recombinant Rat DAB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey DAB1-447C Recombinant Cynomolgus DAB1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey DAB1-193C Recombinant Cynomolgus Monkey DAB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey DAB1-193C-B Recombinant Cynomolgus Monkey DAB1 Protein Pre-coupled Magnetic Beads HEK293
Chicken DAB1-5811C Recombinant Chicken DAB1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DAB1 Related Articles

DAB1 involved in several pathways and played different roles in them. We selected most pathways DAB1 participated on our site, such as Lissencephaly gene (LIS1) in neuronal migration and development, Reelin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Lissencephaly gene (LIS1) in neuronal migration and developmentLRPAP1;DCX;NUDC;MAP1B;VLDLR;NDEL1;KATNA1;DYNLT1;DAB1
Reelin signaling pathwayLRPAP1;DAB1;MAP1B;VLDLR

DAB1 has several biochemical functions, for example, phosphatidylinositol 3-kinase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAB1 itself. We selected most functions DAB1 had, and list some proteins which have the same functions with DAB1. You can find most of the proteins on our site.

Function Related Protein
phosphatidylinositol 3-kinase bindingCALM1;IGF1RA;IRS2;CALM2;HCST;CORO1A;INSRR;IGF1R;INSRB
protein bindingNOL11;LDHD;IL15RA;BPTF;SNX18;GTPBP4;GATA4;CCDC135;TTLL10

DAB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAB1.

a0a024r5s0_human; ZBTB32; ROR2; ARID5A; SIRPB1

Onoue, A; Takeuchi, M; et al. Aberrant fragment of Dab1 protein is present in yotari mouse. NEUROSCIENCE RESEARCH 88:23-27(2014).
Gaillard, F; Kuny, S; et al. Retinal distribution of Disabled-1 in a diurnal murine rodent, the Nile grass rat Arvicanthis niloticus. EXPERIMENTAL EYE RESEARCH 125:236-243(2014).
  • Q&As
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