DAG1
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Official Full Name
dystroglycan 1 (dystrophin-associated glycoprotein 1)
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Overview
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.[provided by RefSeq, Apr 2010] -
Synonyms
DAG1; dystroglycan 1 (dystrophin-associated glycoprotein 1); A3a; DAG; AGRNR; 156DAG; MDDGC7; MDDGC9; dystroglycan;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Human
- Mouse
- Rabbit
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- Fc
- GST
- His
- His (Fc)
- Avi
- Myc
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- DAG1 Related Signal Pathway
DAG1 involved in several pathways and played different roles in them. We selected most pathways DAG1 participated on our site, such as Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Arrhythmogenic right ventricular cardiomyopathy | JUP;CACNG2;DAG1;DMD;DSP;CDH2;CTNNA2;CACNG3;DES |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGA4;CACNA2D2;SGCB;ITGB7;ITGA2B;ITGAV;TCF7L2;CACNB4;SLC8A1 |
Dilated cardiomyopathy | ITGB3;CACNB1;GNAS;MYL2;CACNG4;ITGA6;LAMA2;SGCB;TPM1 |
ECM proteoglycans | FMOD;MUSK;BGNB;BGNA;ITGB3A;COMP;COL9A1;MATN1;COL9A3 |
ECM-receptor interaction | COL6A3;LAMC2;COL11A2;LAMB3;VTNA;ITGA2;COL11A1A;COL4A1;GP1BB |
Extracellular matrix organization | LEPREL2;CTSD;MMP13;TIMP2;DST;DDR1;CTSG;KLK7;COL28A1A |
Hypertrophic cardiomyopathy (HCM) | IGF1;TPM2;SGCG;CACNG7;ITGA2;CACNB3;ITGB3;LMNA;TNNI3 |
Integrated Breast Cancer Pathway | GDI1;MYT1;DCAKD;C21orf7;JAKMIP1;LGALS13;SMARCA4;PLK3;GRN |
DAG1 has several biochemical functions, for example, SH2 domain binding, actin binding, alpha-actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAG1 itself. We selected most functions DAG1 had, and list some proteins which have the same functions with DAG1. You can find most of the proteins on our site.
Function | Related Protein |
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SH2 domain binding | SRC;SHCBP1;JAK2;LAT2;SYNGR3;CTR9;LILRB1;DAG1;AFAP1L2 |
actin binding | MYHZ1.2;SMYHC1;LIMCH1A;EPS8;SPTB;MYO9B;WASF1;SPIRE1A;CLMN |
alpha-actinin binding | LRRC10;ADORA2A;PPARG;DAG1;MYOT;XIRP2;KCNN2;MAGI1;PKD2L1 |
calcium ion binding | PCDHGA10;RCN2;F7I;CDH1;CRELD2;S100A14;SLC25A25A;FBLN7;C2CD4A |
dystroglycan binding | GYLTL1B;MAP2;AGR2;CLASP1;DAG1;DMD;AGRN;AGR3;VCL |
laminin-1 binding | NTN4;SLIT2;Shh;NID1;UBE4A;DAG1;LACRT |
protein binding | SNRPA;GH1;HACE1;PHYHD1;CNTF;CYB5R1;AKR7A3;TRIM29;BFSP1 |
protein complex binding | VPS28;KRIT1;ADRB2;PPFIA2;ING2;HCLS1;SKAP1;DLG4;EPHB1 |
structural constituent of muscle | MYL6;MYL9;PDLIM3;MYBPC3;CAPN3;JPH1;MYBPH;MYL5;MYL6B |
tubulin binding | KIF14;VBP1;STMN3;STMN4;STMN4L;RITA1;TPR;AGBL5;FYN |
vinculin binding | DAG1;C22orf28;SORBS3;CTNNA1;TLN1;ACTN1;SYNM;PXN;DMD |
virus receptor activity | ITGB3;EFNB3;CD4;EFNB2;CLEC5A;SIVA1;AXL;ITGB6;ITGB5 |
DAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAG1.
UTRN; DMD; Grb2; ganglioside_gm1; FYN; GPC; DMD; SRC; NCK1; PIK3R1; GRB2; Ank3; rpoB
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, mouse models with mutations in the DAG1 gene are commonly used to study the pathophysiology of DAG1-related muscle disorders.
Symptoms can include muscle weakness, hypotonia, and developmental delay, as well as eye and brain abnormalities in some cases.
DAG1 protein forms a complex with other proteins and glycoproteins to anchor the muscle cell membrane to the extracellular matrix.
Studies are exploring the potential use of DAG1 protein levels as a diagnostic and prognostic biomarker for muscle disorders.
DAG1 protein forms a complex with dystrophin, sarcoglycans, and other proteins to maintain the stability of the muscle cell membrane.
Customer Reviews (3)
Write a reviewBy utilizing the DAG1 protein in my experiments, I can trust that I am working with a product of the highest caliber, backed by a company dedicated to delivering exceptional quality and support.
The reliability and reproducibility of the DAG1 Protein's performance make it a go-to option for WB experiments.
The DAG1 protein is of exceptional quality and will undoubtedly meet my experimental needs with utmost reliability and accuracy.
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