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DAG1

  • Official Full Name

    dystroglycan 1 (dystrophin-associated glycoprotein 1)

  • Overview

    Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.[provided by RefSeq, Apr 2010]
  • Synonyms

    DAG1; dystroglycan 1 (dystrophin-associated glycoprotein 1); A3a; DAG; AGRNR; 156DAG; MDDGC7; MDDGC9; dystroglycan;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Human
  • Mouse
  • Rabbit
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DAG1-549H Active Recombinant Human DAG1 Protein, His-tagged Mammalian cells His Met1-Val749
Human DAG1-26240TH Recombinant Human DAG1 Wheat Germ N/A 110 amino acids
Human DAG1-620H Recombinant Human DAG1 Protein, His-tagged HEK293 His
Human DAG1-200H Recombinant Human DAG1 Mammalian Cell His
Human DAG1-2327H Recombinant Human DAG1 Protein, GST-tagged Wheat Germ GST
Human DAG1-7082HCL Recombinant Human DAG1 293 Cell Lysate HEK293 N/A
Human DAG1-5889H Recombinant Human DAG1 protein, His-tagged Yeast His 30-653aa
Human DAG1-1273H Recombinant Human DAG1 protein, His&Myc-tagged Insect Cell His&Myc 30-653aa
Human DAG1-1172H Recombinant Human DAG1 protein, His&Myc-tagged E.coli His&Myc 30-653aa
Human DAG1-13H Recombinant Human DAG1 Protein (28-651), Fc-tagged HEK293 C-Fc 28-651
Human DAG1-2774H Recombinant Human DAG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DAG1-09H Active Recombinant Human DAG1 Protein (Gln28-Val749), C-Fc-tagged HEK293 C-Fc Gln28-Val749
Human DAG1-2774H-B Recombinant Human DAG1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Dag1-689M Recombinant Mouse Dag1 Protein, His-tagged E.coli His His28~Pro406
Rabbit DAG1-5936R Recombinant Rabbit DAG1 protein, His&Myc-tagged HEK293 His&Myc 30-653aa
Rabbit DAG1-1212R Recombinant Rabbit DAG1 protein, His-tagged E.coli His 30-653aa
Bos taurus (Bovine) RFL12468BF Recombinant Full Length Bovine Dystroglycan(Dag1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (30-653)
Rhesus Macaque DAG1-1174R Recombinant Rhesus monkey DAG1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DAG1-999R Recombinant Rhesus Macaque DAG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DAG1-999R-B Recombinant Rhesus Macaque DAG1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DAG1-9545Z Recombinant Zebrafish DAG1 Mammalian Cell His
Chicken DAG1-3701C Recombinant Chicken DAG1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DAG1 Related Signal Pathway

DAG1 involved in several pathways and played different roles in them. We selected most pathways DAG1 participated on our site, such as Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arrhythmogenic right ventricular cardiomyopathyJUP;CACNG2;DAG1;DMD;DSP;CDH2;CTNNA2;CACNG3;DES
Arrhythmogenic right ventricular cardiomyopathy (ARVC)ITGA4;CACNA2D2;SGCB;ITGB7;ITGA2B;ITGAV;TCF7L2;CACNB4;SLC8A1
Dilated cardiomyopathyITGB3;CACNB1;GNAS;MYL2;CACNG4;ITGA6;LAMA2;SGCB;TPM1
ECM proteoglycansFMOD;MUSK;BGNB;BGNA;ITGB3A;COMP;COL9A1;MATN1;COL9A3
ECM-receptor interactionCOL6A3;LAMC2;COL11A2;LAMB3;VTNA;ITGA2;COL11A1A;COL4A1;GP1BB
Extracellular matrix organizationLEPREL2;CTSD;MMP13;TIMP2;DST;DDR1;CTSG;KLK7;COL28A1A
Hypertrophic cardiomyopathy (HCM)IGF1;TPM2;SGCG;CACNG7;ITGA2;CACNB3;ITGB3;LMNA;TNNI3
Integrated Breast Cancer PathwayGDI1;MYT1;DCAKD;C21orf7;JAKMIP1;LGALS13;SMARCA4;PLK3;GRN

DAG1 has several biochemical functions, for example, SH2 domain binding, actin binding, alpha-actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAG1 itself. We selected most functions DAG1 had, and list some proteins which have the same functions with DAG1. You can find most of the proteins on our site.

Function Related Protein
SH2 domain bindingSRC;SHCBP1;JAK2;LAT2;SYNGR3;CTR9;LILRB1;DAG1;AFAP1L2
actin bindingMYHZ1.2;SMYHC1;LIMCH1A;EPS8;SPTB;MYO9B;WASF1;SPIRE1A;CLMN
alpha-actinin bindingLRRC10;ADORA2A;PPARG;DAG1;MYOT;XIRP2;KCNN2;MAGI1;PKD2L1
calcium ion bindingPCDHGA10;RCN2;F7I;CDH1;CRELD2;S100A14;SLC25A25A;FBLN7;C2CD4A
dystroglycan bindingGYLTL1B;MAP2;AGR2;CLASP1;DAG1;DMD;AGRN;AGR3;VCL
laminin-1 bindingNTN4;SLIT2;Shh;NID1;UBE4A;DAG1;LACRT
protein bindingSNRPA;GH1;HACE1;PHYHD1;CNTF;CYB5R1;AKR7A3;TRIM29;BFSP1
protein complex bindingVPS28;KRIT1;ADRB2;PPFIA2;ING2;HCLS1;SKAP1;DLG4;EPHB1
structural constituent of muscleMYL6;MYL9;PDLIM3;MYBPC3;CAPN3;JPH1;MYBPH;MYL5;MYL6B
tubulin bindingKIF14;VBP1;STMN3;STMN4;STMN4L;RITA1;TPR;AGBL5;FYN
vinculin bindingDAG1;C22orf28;SORBS3;CTNNA1;TLN1;ACTN1;SYNM;PXN;DMD
virus receptor activityITGB3;EFNB3;CD4;EFNB2;CLEC5A;SIVA1;AXL;ITGB6;ITGB5

DAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAG1.

UTRN; DMD; Grb2; ganglioside_gm1; FYN; GPC; DMD; SRC; NCK1; PIK3R1; GRB2; Ank3; rpoB

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any specific animal models used to study DAG1-related muscle disorders? 03/30/2023

Yes, mouse models with mutations in the DAG1 gene are commonly used to study the pathophysiology of DAG1-related muscle disorders.

What are the symptoms of DAG1-related muscle disorders? 01/06/2023

Symptoms can include muscle weakness, hypotonia, and developmental delay, as well as eye and brain abnormalities in some cases.

How does DAG1 protein contribute to the stability of muscle cell membranes? 05/02/2022

DAG1 protein forms a complex with other proteins and glycoproteins to anchor the muscle cell membrane to the extracellular matrix.

Can DAG1 protein be used as a biomarker for muscle disorders? 03/13/2022

Studies are exploring the potential use of DAG1 protein levels as a diagnostic and prognostic biomarker for muscle disorders.

How does DAG1 protein interact with other proteins in the muscle cell membrane? 09/07/2017

DAG1 protein forms a complex with dystrophin, sarcoglycans, and other proteins to maintain the stability of the muscle cell membrane.

Customer Reviews (3)

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Reviews
08/17/2022

    By utilizing the DAG1 protein in my experiments, I can trust that I am working with a product of the highest caliber, backed by a company dedicated to delivering exceptional quality and support.

    01/23/2022

      The reliability and reproducibility of the DAG1 Protein's performance make it a go-to option for WB experiments.

      03/12/2021

        The DAG1 protein is of exceptional quality and will undoubtedly meet my experimental needs with utmost reliability and accuracy.

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