DAPK1
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Official Full Name
death-associated protein kinase 1
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Overview
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. -
Synonyms
DAPK1; death-associated protein kinase 1; DAPK; DAP kinase 1; DKFZp781I035;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- GST
- GST|His
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- DAPK1 Related Articles
DAPK1 involved in several pathways and played different roles in them. We selected most pathways DAPK1 participated on our site, such as Apoptosis, Bladder cancer, Caspase activation via extrinsic apoptotic signalig pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Apoptosis | GAS2;MAP3K14;PRKACB;IRF6;PRKAR1B;PPP3CB;IL1RAP;BAXA;GZMF |
Bladder cancer | MYC;UPK3A;EGF;ERBB2;MAPK3;RAF1;CCND1;MAPK1;MDM2 |
Caspase activation via extrinsic apoptotic signalig pathway | DCC;DAPK3;CASP8L1;RNF8;DAPK1;TICAM1 |
IFN-gamma pathway | IRF9;DAPK1 |
Ligand-independent caspase activation via DCC | DAPK1;RNF8;DAPK3 |
Pathways in cancer | RAC3;FGF5;GNAQ;RET;SLC2A1;LPAR4;PIK3R1;BDKRB1;PPARD |
Programmed Cell Death | ADD1;DBNL;DIABLOA;STK26;DSG3;GZMF;STK24;PLECA;HMGB2A |
DAPK1 has several biochemical functions, for example, ATP binding, GTP binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAPK1 itself. We selected most functions DAPK1 had, and list some proteins which have the same functions with DAPK1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | TNIKB;EIF2B2;SGK2;MTHFD1;HK1;DDX54;MAPKAPK2;C22orf28;MVDA |
GTP binding | RAB43;GMPPAB;RAB9B;TUBA8L;RHOV;IRGQ;RAB2A;GNA13A;RAB14L |
calmodulin binding | GAP43;TRPV6;SPHK1;MYH9;ADD3;CNN3A;MYO1D;SNTA1;DAPK2 |
calmodulin-dependent protein kinase activity | CAMK2D1;CAMK1GB;PTK2B;DCX;CAMK1D;CAMK1;MAPKAPK2;MAPKAPK2B;CAMK2D |
identical protein binding | PDGFB;GUCY2E;PRDX1;LRRK1;ZHX2;SNX1;FHOD1;TTC32;SEPHS1 |
protein binding | CD79B;NBL1;C1QTNF6;ADRBK1;SCO2;PICK1;WBSCR27;OPA1;HEYL |
protein kinase activity | CSNK1D;RIPK1L;NEK2;SOX9;PRKAB1;EPHB4A;LIMK1A;TGFBR1;KDRL |
protein serine/threonine kinase activity | SNRK;CAMK1DA;NIM1;MAP3K10;TP53RK;STK33;WNK1;MAP2K1;RIOK3 |
syntaxin-1 binding | NSF;SNPH;SNAP25B;MYO5A;STXBP3;SYBU;RNF40;VAMP3;SNAP25A |
DAPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAPK1.
N/A; KLHL20; MAPK3
- Q&As
- Reviews
Q&As (6)
Ask a questionDAPK1 plays an important role in apoptosis, which can promote the process of apoptosis.
There are currently no drugs that directly regulate DAPK1 levels, but some DAPK1-related diseases can be treated by modulating its activity or regulating its expression.
DAPK1 has a complex relationship with other genes or proteins, and can interact with other genes or proteins to participate in a variety of biochemical reactions.
Mutations in DAPK1 can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.
The types of mutations in DAPK1 include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.
Studying the regulatory mechanism of DAPK1 requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.
Customer Reviews (3)
Write a reviewDAPK1 had the intended biological effect in the experiment.
I've used many brands, but this one is one of my favorites.
Good stability under different temperature and humidity conditions.
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