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DAPK1

  • Official Full Name

    death-associated protein kinase 1

  • Overview

    Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
  • Synonyms

    DAPK1; death-associated protein kinase 1; DAPK; DAP kinase 1; DKFZp781I035;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DAPK1-1395H Active Recombinant Human DAPK1, GST-tagged Sf9 Insect Cell GST 1-363 aa
Human DAPK1-289H Recombinant Human DAPK1, GST-tagged, Active Sf9 Insect Cell GST
Human DAPK1-11825H Recombinant Human DAPK1, GST-tagged E.coli GST 1081-1410a.a.
Human DAPK1-2336H Active Recombinant Human DAPK1 Protein, His-tagged Insect Cell His
Human DAPK1-2335H Active Recombinant HumanPK1 DAPK1 Protein, GST-His-tagged Insect Cell GST/His
Human DAPK1-971H Active Recombinant Human DAPK1 protein, His&GST-tagged Insect Cells His/GST Met1-Leu363
Human DAPK1-27363TH Recombinant Human DAPK1 N/A
Human DAPK1-2337H Recombinant Human DAPK1 Protein, GST-tagged Wheat Germ GST
Human DAPK1-602HCL Recombinant Human DAPK1 cell lysate Insect Cell N/A
Human DAPK1-2903H Recombinant Human DAPK1 protein, His-tagged E.coli His 1081-1410 aa
Human DAPK1-985H Recombinant Human DAPK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DAPK1-0183H Recombinant Human DAPK1 Protein (L397-R1430), Tag Free Insect Cell No tag L397-R1430
Human DAPK1-2455HF Recombinant Full Length Human DAPK1 Protein, GST-tagged In Vitro Cell Free System GST 368 amino acids
Human DAPK1-0184H Recombinant Human DAPK1 Protein (L397-R1430), GST tagged Insect Cell GST L397-R1430
Mouse DAPK1-4304M Recombinant Mouse DAPK1 Protein Mammalian Cell His
Mouse DAPK1-2200M Recombinant Mouse DAPK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Dapk1-2451M Recombinant Mouse Dapk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DAPK1-2200M-B Recombinant Mouse DAPK1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DAPK1-1176R Recombinant Rhesus monkey DAPK1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DAPK1-1001R-B Recombinant Rhesus Macaque DAPK1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DAPK1-1001R Recombinant Rhesus Macaque DAPK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DAPK1-5801Z Recombinant Zebrafish DAPK1 Mammalian Cell His
Chicken DAPK1-3251C Recombinant Chicken DAPK1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DAPK1 Related Articles

DAPK1 involved in several pathways and played different roles in them. We selected most pathways DAPK1 participated on our site, such as Apoptosis, Bladder cancer, Caspase activation via extrinsic apoptotic signalig pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ApoptosisGAS2;MAP3K14;PRKACB;IRF6;PRKAR1B;PPP3CB;IL1RAP;BAXA;GZMF
Bladder cancerMYC;UPK3A;EGF;ERBB2;MAPK3;RAF1;CCND1;MAPK1;MDM2
Caspase activation via extrinsic apoptotic signalig pathwayDCC;DAPK3;CASP8L1;RNF8;DAPK1;TICAM1
IFN-gamma pathwayIRF9;DAPK1
Ligand-independent caspase activation via DCCDAPK1;RNF8;DAPK3
Pathways in cancerRAC3;FGF5;GNAQ;RET;SLC2A1;LPAR4;PIK3R1;BDKRB1;PPARD
Programmed Cell DeathADD1;DBNL;DIABLOA;STK26;DSG3;GZMF;STK24;PLECA;HMGB2A

DAPK1 has several biochemical functions, for example, ATP binding, GTP binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAPK1 itself. We selected most functions DAPK1 had, and list some proteins which have the same functions with DAPK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTNIKB;EIF2B2;SGK2;MTHFD1;HK1;DDX54;MAPKAPK2;C22orf28;MVDA
GTP bindingRAB43;GMPPAB;RAB9B;TUBA8L;RHOV;IRGQ;RAB2A;GNA13A;RAB14L
calmodulin bindingGAP43;TRPV6;SPHK1;MYH9;ADD3;CNN3A;MYO1D;SNTA1;DAPK2
calmodulin-dependent protein kinase activityCAMK2D1;CAMK1GB;PTK2B;DCX;CAMK1D;CAMK1;MAPKAPK2;MAPKAPK2B;CAMK2D
identical protein bindingPDGFB;GUCY2E;PRDX1;LRRK1;ZHX2;SNX1;FHOD1;TTC32;SEPHS1
protein bindingCD79B;NBL1;C1QTNF6;ADRBK1;SCO2;PICK1;WBSCR27;OPA1;HEYL
protein kinase activityCSNK1D;RIPK1L;NEK2;SOX9;PRKAB1;EPHB4A;LIMK1A;TGFBR1;KDRL
protein serine/threonine kinase activitySNRK;CAMK1DA;NIM1;MAP3K10;TP53RK;STK33;WNK1;MAP2K1;RIOK3
syntaxin-1 bindingNSF;SNPH;SNAP25B;MYO5A;STXBP3;SYBU;RNF40;VAMP3;SNAP25A

DAPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAPK1.

N/A; KLHL20; MAPK3

Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
Jin, XH; Wu, XX; et al. Delineation of apoptotic genes for synergistic apoptosis of lexatumumab and anthracyclines in human renal cell carcinoma cells by polymerase chain reaction array. ANTI-CANCER DRUGS 23:445-454(2012).
  • Q&As
  • Reviews

Q&As (6)

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What is the specific role of DAPK1 in apoptosis? 05/04/2022

DAPK1 plays an important role in apoptosis, which can promote the process of apoptosis.

How can diseases be treated by regulating DAPK1 levels? 08/16/2021

There are currently no drugs that directly regulate DAPK1 levels, but some DAPK1-related diseases can be treated by modulating its activity or regulating its expression.

What is the relationship of DAPK1 to other genes or proteins? 06/23/2020

DAPK1 has a complex relationship with other genes or proteins, and can interact with other genes or proteins to participate in a variety of biochemical reactions.

How to detect and analyze mutations in DAPK1? 05/12/2020

Mutations in DAPK1 can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.

What are the mutation types of DAPK1? 04/20/2020

The types of mutations in DAPK1 include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

How to study the regulatory mechanism of DAPK1? 01/09/2020

Studying the regulatory mechanism of DAPK1 requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

Customer Reviews (3)

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Reviews
12/15/2022

    DAPK1 had the intended biological effect in the experiment.

    04/11/2022

      I've used many brands, but this one is one of my favorites.

      03/17/2022

        Good stability under different temperature and humidity conditions.

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