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DBF4

  • Official Full Name

    DBF4 homolog

  • Overview

    Protein DBF4 homolog A is a protein that in humans is encoded by the DBF4 gene.
  • Synonyms

    DBF4; DBF4 homolog (S. cerevisiae); protein DBF4 homolog A; activator of S phase kinase; ASK; chif; chiffon homolog (Drosophila); DBF4A; ZDBF1; zinc finger; DBF type containing 1; chiffon homolog A; zinc finger, DBF-type containing 1; DBF4-type zinc finge;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Zebrafish
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DBF4-689H Recombinant Human DBF4 Mammalian Cell His
Human ASK-908H Recombinant Human ASK protein, GST-tagged Wheat Germ GST
Human DBF4-7067HCL Recombinant Human DBF4 293 Cell Lysate HEK293 N/A
Human DBF4-2777H Recombinant Human DBF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DBF4-2777H-B Recombinant Human DBF4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DBF4-7188Z Recombinant Zebrafish DBF4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DBF4 Related Articles

DBF4 involved in several pathways and played different roles in them. We selected most pathways DBF4 participated on our site, such as Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with DBF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of ATR in response to replication stressRAD9;RAD1;RAD9A;MCM10;CHEK1;HUS1;RAD9B;RAD17;MCM8
Activation of the pre-replicative complexCDK2;MCM8;MCM10;CDT1;DBF4
Cell CycleDCTN2;POLD3;OFD1;SDCCAG8;PSMC3IP;CDC6;CLIP1;CTDNEP1A;GADD45AB
Cell Cycle CheckpointsRAD17;CDK2;BABAM1;RNF168;BRE;THRSP;BRCC3;RAD9;CDKN1B
Cell Cycle, MitoticOFD1;NSL1;RANGAP1B;GINS4;NDEL1;SET;WAPAL;CCDC99;CTDNEP1B
DNA ReplicationRFC2;RNASEH2C;RNASEH1;MCM3;RPA3;RFC1;POLE2;MCM3L;MCM6
DNA Replication Pre-InitiationCDT1;DBF4;MCM10;GMNN

DBF4 has several biochemical functions, for example, enzyme activator activity, nucleic acid binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DBF4 itself. We selected most functions DBF4 had, and list some proteins which have the same functions with DBF4. You can find most of the proteins on our site.

Function Related Protein
enzyme activator activityTIMP2;GTF3C4;DBF4;MMP17;SAE1;MMP16;CTSA;TRIM23;RAB3GAP2
nucleic acid bindingZFP35;RBAK;SRSF7B;ZNF292A;SALL3;GFI1AA;REXO1L1;ZXDB;PRDM12B
zinc ion bindingADA;NR2F6A;RNF148;TRIM47;CA4B;SKI;LMO4;CPXM1;NR5A2

DBF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DBF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DBF4.

CDC7; CHAF1A; LSM8

Charych, DH; Coyne, M; et al. Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells. JOURNAL OF CELLULAR BIOCHEMISTRY 104:1075-1086(2008).
Tsuji, T; Ficarro, SB; et al. Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. MOLECULAR BIOLOGY OF THE CELL 17:4459-4472(2006).
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