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DBT

  • Official Full Name

    dihydrolipoamide branched chain transacylase E2

  • Overview

    The branched-chain alpha-keto acid dehydrogenase complex (BCKD) is an inner-mitochondrial enzyme complex involved in the breakdown of the branched-chain amino acids isoleucine, leucine, and valine. The BCKD complex is thought to be composed of a core of 24 transacylase (E2) subunits, and associated decarboxylase (E1), dehydrogenase (E3), and regulatory subunits. This gene encodes the transacylase (E2) subunit. Mutations in this gene result in maple syrup urine disease, type 2. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
  • Synonyms

    DBT; dihydrolipoamide branched chain transacylase E2; dihydrolipoamide branched chain transacylase (E2 component of branched chain keto acid dehydrogenase complex; maple syrup urine disease); lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial; E2B; BCATE2; BCKAD E2 subunit; Branched chain acyltransferase, E2 component; Dihydrolipoamide branched chain transacylase; Dihydrolipoyl transacylase; Dihydrolipoyllysine residue (2 methylpropanoyl)transferase; E2; E2 component of branched chain alpha keto acid dehydrogenase complex; Lipoamide acyltransferase component of mitochondrial branched chain alpha keto acid dehydrogenase complex; Mitochondrial branched chain alpha keto acid dehydrogenase transacylase subunit (E2b); BCKADE2; BCKAD-E2; dihydrolipoyllysine-residue (2-methylpropanoyl)transferase; branched-chain alpha-keto acid dehydrogenase complex component E2; E2 component of branched chain alpha-keto acid dehydrogenase complex; mitochondrial branched chain alpha-keto acid dehydrogenase transacylase subunit (E2b); dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; lipoamide acyltransferase component of mitochondrial branched-chain alpha-keto acid dehydrogenase complex;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DBT-4930H Recombinant Human DBT protein, His-tagged Insect Cell His
Human DBT-2376H Recombinant Human DBT Protein, GST-tagged Wheat Germ GST
Human DBT-7061H Recombinant Human DBT protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DBT-7061HCL Recombinant Human DBT 293 Cell Lysate HEK293 N/A
Human DBT-7658HFL Recombinant Full Length Human DBT protein, Flag-tagged Mamanlian cells Flag
Human DBT-2712HF Recombinant Full Length Human DBT Protein, GST-tagged In Vitro Cell Free System GST 482 amino acids
Human DBT-10H Recombinant Human DBT protein, His-tagged E.coli C-His 71-330 aa
Mouse DBT-4326M Recombinant Mouse DBT Protein Mammalian Cell His
Mouse DBT-2213M-B Recombinant Mouse DBT Protein Pre-coupled Magnetic Beads HEK293
Mouse Dbt-2467M Recombinant Mouse Dbt Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DBT-2213M Recombinant Mouse DBT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DBT-1182R Recombinant Rhesus monkey DBT Protein, His-tagged Mammalian Cell His
Rhesus Macaque DBT-1007R-B Recombinant Rhesus Macaque DBT Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DBT-1007R Recombinant Rhesus Macaque DBT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DBT-2183Z Recombinant Zebrafish DBT Mammalian Cell His
Chicken DBT-6224C Recombinant Chicken DBT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DBT Related Articles

DBT involved in several pathways and played different roles in them. We selected most pathways DBT participated on our site, such as 2-oxobutanoate degradation, 2-oxobutanoate degradation I, 2-oxoisovalerate decarboxylation to isobutanoyl-CoA, which may be useful for your reference. Also, other proteins which involved in the same pathway with DBT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
2-oxobutanoate degradationDBT;DLD
2-oxobutanoate degradation IDBT;DLD
2-oxoisovalerate decarboxylation to isobutanoyl-CoADLD;DBT
Biosynthesis of antibioticsAMDHD2;SDS;ACAA2;GALM;pykF;ADH5;DLST;EHHADH;ADSL
Branched-chain amino acid catabolismDLD;IVD;DBT;ALDH9A1A.2;HIBADHA;PPM1K;HIBADH;BCKDK
L-isoleucine degradation I
L-leucine degradation I
L-threonine degradation VDBT;SDS;SDSL

DBT has several biochemical functions, for example, dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DBT itself. We selected most functions DBT had, and list some proteins which have the same functions with DBT. You can find most of the proteins on our site.

Function Related Protein
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity
ubiquitin protein ligase bindingGLMN;DTX1;HSPD1;TRIOBP;PIAS1;Fzd4;XRCC5;WFS1;TRAF2

DBT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DBT here. Most of them are supplied by our site. Hope this information will be useful for your research of DBT.

TNFRSF1B; ADI1; USP16; IFIT2; YBX1; ICT1; ACAD9; AGO3; AGO4; HDAC6; SIRT4; Hdac6

Cato, A; Celada, L; et al. Brominated flame retardants, tetrabromobisphenol A and hexabromocyclododecane, activate mitogen-activated protein kinases (MAPKs) in human natural killer cells. CELL BIOLOGY AND TOXICOLOGY 30:345-360(2014).
Celada, LJ; Whalen, MM; et al. Effects of butyltins on mitogen-activated-protein kinase kinase kinase and Ras activity in human natural killer cells. JOURNAL OF APPLIED TOXICOLOGY 34:1002-1011(2014).
  • Q&As
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