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DCLK1

  • Official Full Name

    doublecortin-like kinase 1

  • Overview

    This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.
  • Synonyms

    DCLK1; doublecortin-like kinase 1; serine/threonine-protein kinase DCLK1; doublecortin-like and CAM kinase-like 1; double cortin and calcium/calmodulin-dependent protein kinase-like 1; Ania4; Cpg16; Dcamkl1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DCLK1-324H Active Recombinant Human DCLK1 Protein, His & GST-tagged Insect Cell His/GST
Human DCLK1-1009H Recombinant Human Doublecortin-like Kinase 1, GST-tagged Sf9 Insect Cell GST
Human DCLK1-519H Recombinant Human DCLK1, Gly & Pro tagged Insect Cell His
Human DCLK1-2392H Active Recombinant Human DCLK1 Protein, GST-tagged Insect Cell GST
Human DCLK1-2383H Recombinant Human DCLK1 Protein, GST-tagged Wheat Germ GST
Human DCLK1-26808TH Recombinant Human DCLK1 Insect Cell N/A 740 amino acids
Human DCLK1-001HCL Recombinant Human DCLK1 cell lysate Insect Cell N/A
Human DCLK1-435HCL Recombinant Human DCLK1 cell lysate Insect Cell N/A
Human DCLK1-0399H Recombinant Human DCLK1 protein, His-tagged E.coli His 623-729 aa
Human DCLK1-1169H Recombinant Human DCLK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DCLK1-6504HF Active Recombinant Full Length Human DCLK1 Protein, GST-tagged Insect (sf21) GST 1-729
Human DCLK1-725H-B Recombinant Human DCLK1 Protein Pre-coupled Magnetic Beads HEK293
Human DCLK1-0862H Recombinant Human DCLK1 Protein (S2-F740), Tag Free Insect Cell No tag S2-F740
Human DCLK1-01H Recombinant Human DCLK1 Protein, His-tagged Insect Cell His
Human DCLK1-725H Recombinant Human DCLK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DCLK1-211H Recombinant Human DCLK1 Protein, His-tagged E.coli His Tyr390~Val647
Human DCLK1-723HFL Recombinant Full Length Human DCLK1 Protein, C-Flag-tagged Mammalian cells Flag
Human DCLK1-0863H Recombinant Human DCLK1 Protein (S2-F740), GST tagged Insect Cell GST S2-F740
Mouse Dclk1-2473M Recombinant Mouse Dclk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Chicken DCLK1-4602C Recombinant Chicken DCLK1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DCLK1 Related Research Area

DCLK1 involved in several pathways and played different roles in them. We selected most pathways DCLK1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DCLK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

DCLK1 has several biochemical functions, for example, ATP binding, protein kinase activity, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DCLK1 itself. We selected most functions DCLK1 had, and list some proteins which have the same functions with DCLK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATRX;SMC1AL;MAP3K2;TUT1;DMPK;ETNK1;DDX17;CFTR;DDX23
protein kinase activityMKNK2B;PRKACAB;PRKAG1;RPS6KB2;NPRL2;DCLK2;IGF1RA;ACVR1;PDK3
protein serine/threonine kinase activitySGK1;PDK3;ALPK2;LIMK1;PIK3R4;CAMK1GA;SLK;AKT2L;STK35
receptor signaling protein activityIFITM1;NGF;BAG4;RAF1B;DOK2;ARAF;FLRT3;PLCE1;DOK1

DCLK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCLK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DCLK1.

xmd8-92; MYC

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