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DCP2

  • Official Full Name

    decapping mRNA 2

  • Overview

    The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5 end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
  • Synonyms

    DCP2; decapping mRNA 2; NUDT20; m7GpppN-mRNA hydrolase; hDpc; mRNA-decapping enzyme 2; DCP2 decapping enzyme homolog; nudix (nucleoside diphosphate linked moiety X)-type motif 20;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DCP2-1570H Recombinant Human DCP2 protein E.coli N/A
Human DCP2-11861H Recombinant Human DCP2 protein, His-tagged E.coli His 1-385aa
Human DCP2-2402H Recombinant Human DCP2 Protein, GST-tagged Wheat Germ GST
Human DCP2-446HCL Recombinant Human DCP2 cell lysate N/A
Human DCP2-1690H Recombinant Human DCP2 Protein (1-385 aa), His-tagged Yeast His 1-385 aa
Human DCP2-2893HF Recombinant Full Length Human DCP2 Protein, GST-tagged In Vitro Cell Free System GST 385 amino acids
Rhesus Macaque DCP2-1193R Recombinant Rhesus monkey DCP2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DCP2-1018R Recombinant Rhesus Macaque DCP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DCP2-1018R-B Recombinant Rhesus Macaque DCP2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DCP2-10499Z Recombinant Zebrafish DCP2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DCP2 involved in several pathways and played different roles in them. We selected most pathways DCP2 participated on our site, such as ATF4 activates genes, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ATF4 activates genesDCP2;EXOSC8;KCNA3;DDIT3
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNAZFP36L1A;EXOSC8;DCP2;ZFP36L1B;ZFP36L1;MAPKAPK2B
Deadenylation-dependent mRNA decayNT5C3B;PAIP1;EIF4A1;C2orf29;LSM6;DCP1B;EIF4E;DDX6;EIF4G1
Gene ExpressionZNF561;CHST13;YBX1;EIF2S1A;HNRPL;ZNF483;CTDP1;NRBF2B;NXF1
KSRP (KHSRP) binds and destabilizes mRNADCP2;EXOSC8;KHSRP
Metabolism of proteinsADAMTSL1;TOMM22;ST3GAL3A;KIFC3;DNAJC24;TMED10;TIMM50;NAT8B;MAN1A2
PERK regulates gene expressionDCP2;EXOSC8
RNA degradationCNOT6L;CNOT7;ENO1B;PFKP;SMX5;ENO1;DIS3L;TTC37;CNOT10

DCP2 has several biochemical functions, for example, RNA binding, exoribonuclease activity, producing 5-phosphomonoesters, m7G(5)pppN diphosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DCP2 itself. We selected most functions DCP2 had, and list some proteins which have the same functions with DCP2. You can find most of the proteins on our site.

Function Related Protein
RNA bindingRNASEL2;RPL5;ATXN2;EXOSC9;SYNCRIP;SNRPD1;TDRKH;PABPN1;RPS15A
exoribonuclease activity, producing 5-phosphomonoesters
m7G(5)pppN diphosphatase activityDCP2;DCPS;NUDT16
manganese ion bindingPPEF2;TDP2B;ENDOU;B4GALT7;TDP2;DYRK2;GALNT1;PAPOLA;ABL1
protein bindingZDHHC13;DCPS;IQCE;HTR3E;CFTR;CST1;TNFRSF11A;FOXH1;FXR2

DCP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DCP2.

DCP1A; UPF1; EDC4; Edc4; DCP1B

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