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DDB1

  • Official Full Name

    damage-specific DNA binding protein 1, 127kDa

  • Overview

    This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.
  • Synonyms

    Damage specific DNA binding protein 1; Damage-specific DNA-binding protein 1; DDB 1; DDB p127 subunit; Ddb1; DDB1_HUMAN; DDBa; DNA damage binding protein 1; DNA damage-binding protein 1; DNA damage-binding protein a; HBV X-associated protein 1; UV damaged DNA binding factor; UV-damaged DNA-binding protein 1; UV DDB 1; UV DDB1; UV-damaged DNA-binding factor; X associated protein 1; XAP 1; XAP-1; XAP1; Xeroderma pigmentosum group E complementing protein; Xeroderma pigmentosum group E-complementing protein; XPCE; XPE; XPE BF; XPE binding factor; XPE-binding factor;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DDB1-28308TH Recombinant Human DDB1 protein, GST-tagged Wheat Germ GST
Human DDB1-11877H Recombinant Human DDB1 protein, His-tagged E.coli His 1-400 aa
Human DDB1-3982H Recombinant Human DDB1 Protein Insect cell
Human DDB1-6896HF Recombinant Full Length Human DDB1 Protein, GST-tagged In Vitro Cell Free System GST 1140 amino acids
Human DDB1-928H Recombinant Human DDB1/CRBN Complex Protein Insect cell
Mouse DDB1-4381M Recombinant Mouse DDB1 Protein Mammalian Cell His
Mouse DDB1-2251M Recombinant Mouse DDB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DDB1-2251M-B Recombinant Mouse DDB1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DDB1-10899Z Recombinant Zebrafish DDB1 Mammalian Cell His
Chicken DDB1-5790C Recombinant Chicken DDB1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DDB1 involved in several pathways and played different roles in them. We selected most pathways DDB1 participated on our site, such as DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DNA Damage BypassUSP10;DTL;RAD18;USP43A;UBE2L6;KIAA0101;SPRTN;ZBTB32;POLI
DNA Damage Recognition in GG-NERCETN2;DDB1;NFRKB;PARP2;INO80E;TFPT;INO80B;DDB2;GPS1
DNA RepairCHEK1;DDB2;PPP4CA;CHEK2;TDP2B;PARP2;APITD1;DNA2;COPS4
Dual Incision in GG-NERCHD1L;DDB2;DDB1;PARP2
Dual incision in TC-NERZNF830;PPIE;DDB1;KIAA1530;ERCC8;ZFP830;TCEA1
Formation of Incision Complex in GG-NERDDB1;DDB2;RNF111;CETN2;USP45;PIAS3;PARP2;CHD1L
Formation of TC-NER Pre-Incision ComplexZNF830;TCEA1;KIAA1530;COPS6;COPS7A;COPS4;COPS5;GPS1;ZFP830
Gap-filling DNA repair synthesis and ligation in TC-NERERCC8;TCEA1;DDB1;KIAA1530;PPIE;ZNF830;ZFP830

DDB1 has several biochemical functions, for example, DNA binding, contributes_to damaged DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDB1 itself. We selected most functions DDB1 had, and list some proteins which have the same functions with DDB1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingOTPA;ZFP426;MYCB;ZBTB25;ESRRGA;GM14482;BANF2;CALR;CASP8AP2
contributes_to damaged DNA bindingCUL4B;DDB2;NBN;DDB1
protein bindingHBQ1;TMEM190;CHCHD2;CDK11B;ENC1;NEK3;DNTT;SMOC1;KLF4

DDB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDB1.

CUL4B; DDB2; CUL4A

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