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DDOST

  • Official Full Name

    dolichyl-diphosphooligosaccharide--protein glycosyltransferase

  • Overview

    This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.
  • Synonyms

    DDOST; dolichyl-diphosphooligosaccharide--protein glycosyltransferase; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; KIAA0115; MGC2191; OK/SW-cl.45; OST; OST48; WBP1; AGE R1; DDOST 48 kDa subunit; Dolichyl-diphosphooligosaccharide-protein glycosyltransferase; EC 2.4.1.119; Oligosaccharyl transferase 48 kDa subunit; RP23-25C1.4; wu:fa11d01; zgc:66068; zgc:77478; advanced glycation endproduct receptor 1; oligosaccharyltransferase 48 kDa subunit; dolichyl-diphosphooligosaccharide-protein glycotransferase; AGER1; OKSWcl45;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DDOST-11884H Recombinant Human DDOST, His-tagged E.coli His 92-433a.a.
Human DDOST-2451H Recombinant Human DDOST Protein, GST-tagged Wheat Germ GST
Human DDOST-1127H Recombinant Human DDOST protein E.coli N/A Ser43-Pro427
Human DDOST-211H Recombinant Human DDOST Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DDOST-7024HCL Recombinant Human DDOST 293 Cell Lysate HEK293 N/A
Human DDOST-1937H Recombinant Human DDOST Protein (Ser43-Pro427), N-His tagged E.coli N-His Ser43-Pro427
Human DDOST-2468HF Recombinant Full Length Human DDOST Protein, GST-tagged In Vitro Cell Free System GST 456 amino acids
Human DDOST-6049H Recombinant Human DDOST Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse DDOST-4392M Recombinant Mouse DDOST Protein Mammalian Cell His
Mouse DDOST-2258M Recombinant Mouse DDOST Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ddost-2495M Recombinant Mouse Ddost Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Ddost-1653M Recombinant Mouse Ddost protein, His-tagged E.coli His Gly29~Pro412 (Accession # O54734)
Mouse DDOST-2258M-B Recombinant Mouse DDOST Protein Pre-coupled Magnetic Beads HEK293
Rat DDOST-1814R Recombinant Rat DDOST Protein Mammalian Cell His
Rat DDOST-1472R-B Recombinant Rat DDOST Protein Pre-coupled Magnetic Beads HEK293
Rat DDOST-1472R Recombinant Rat DDOST Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL6348BF Recombinant Full Length Bovine Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 48 Kda Subunit(Ddost) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-439)
Gallus gallus (Chicken) RFL10395GF Recombinant Full Length Chicken Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 48 Kda Subunit(Ddost) Protein, His-Tagged E.coli expression system His Full Length (1-413)
Homo sapiens (Human) RFL15341HF Recombinant Full Length Human Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 48 Kda Subunit(Ddost) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (43-456)
Mus musculus (Mouse) RFL21581MF Recombinant Full Length Mouse Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 48 Kda Subunit(Ddost) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (29-441)
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) RFL34520XF Recombinant Full Length Xenopus Tropicalis Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 48 Kda Subunit(Ddost) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-437)
Zebrafish DDOST-12319Z Recombinant Zebrafish DDOST Mammalian Cell His
Chicken DDOST-4040C Recombinant Chicken DDOST Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DDOST involved in several pathways and played different roles in them. We selected most pathways DDOST participated on our site, such as AGE/RAGE pathway, Advanced glycosylation endproduct receptor signaling, Asparagine N-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDOST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AGE/RAGE pathwayCHUK;EGFR;AGER;DIAPH1;JAK2;MMP13;TIRAP;MAPK14;ATF2
Advanced glycosylation endproduct receptor signalingAPPA;S100A12;AGER;LGALS3;DDOST;APPB;ALCAMB;SAA1;S100B
Asparagine N-linked glycosylationNSFB;SEC24A;TRAPPC6A;TMED10;GOLGA2;NEU3;NAPAA;SEC16B;OS9
Gene ExpressionDDX20;TSNAX;SUPT4H1;TRMT5;ZNF136;ZNF324;ZCRB1;ZNF571;CD2BP2
Immune SystemIRF6;CTSE;KIR2DS2;GZMM;RNF220;DYNLL2;BTR12;LAIR1;CD200R1
Innate Immune SystemPLD4;RNF135;BTR29;RIPK3;HBL3;PANX1;BTR30;DDX41;TAX1BP1
Metabolic pathwaysPEMT;PPT2;LTA4H;PIGS;PAPSS2A;B3GNT5A;DBH;NDST4;BPNT1
Metabolism of proteinsTOMM7;CEACAM21;EIF5A;YY2;ADAMTS1;TRAPPC6BL;ALG10B;SLC25A13;GALNTL2

DDOST has several biochemical functions, for example, contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity, contributes_to oligosaccharyl transferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDOST itself. We selected most functions DDOST had, and list some proteins which have the same functions with DDOST. You can find most of the proteins on our site.

Function Related Protein
contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activitySTT3A;OSTC;DDOST;RPN1;TUSC3;DAD1;RPN2
contributes_to oligosaccharyl transferase activityDAD1;DDOST
protein bindingHSPA13;ANXA10;ATF6B;TRAPPC6B;MAGEE1;LGALS1;AGTR1A;ZNF335;LILRB4

DDOST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDOST here. Most of them are supplied by our site. Hope this information will be useful for your research of DDOST.

TMEM173; SEC27; copa_schpo; 7242199; PGRMC1; SAP18; RFXANK; PTP4A3; TNFRSF1A; TNFRSF1B; MCC; HLA-B; MAGEA6; BRCC3; COP1; EIF6; ARF6; SMYD3; TMBIM4

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