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DDX23

  • Official Full Name

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

  • Overview

    This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined.
  • Synonyms

    DDX23; DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; PRP28 homolog, yeast; probable ATP-dependent RNA helicase DDX23; prp28; PRPF28; U5 100K; PRP28p homolog; DEAD box protein 23; U5 snRNP 100 kD protein; 100 kDa U5 snRNP-specific protein; U5-100K; U5-100KD;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DDX23-2475H Recombinant Human DDX23 Protein, GST-tagged Wheat Germ GST
Human DDX23-11896H Recombinant Human DDX23, GST-tagged E.coli GST 614-820a.a.
Human DDX23-7014HCL Recombinant Human DDX23 293 Cell Lysate HEK293 N/A
Human DDX23-2562HF Recombinant Full Length Human DDX23 Protein, GST-tagged In Vitro Cell Free System GST 820 amino acids
Human DDX23-2963H Recombinant Human DDX23 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DDX23-1267H Recombinant Human DDX23 protein, His-SUMO-tagged E.coli His Ile422~Pro799
Mouse Ddx23-2503M Recombinant Mouse Ddx23 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque DDX23-1213R Recombinant Rhesus monkey DDX23 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DDX23-1038R Recombinant Rhesus Macaque DDX23 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DDX23-1038R-B Recombinant Rhesus Macaque DDX23 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DDX23-10254Z Recombinant Zebrafish DDX23 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DDX23 involved in several pathways and played different roles in them. We selected most pathways DDX23 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX23 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
SpliceosomeSMNDC1;HSP70;PRP19;SNRPF;PRPF6;U2AF2B;LSM6;SF3B14;SFRS3B

DDX23 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, NOT ATP-dependent helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX23 itself. We selected most functions DDX23 had, and list some proteins which have the same functions with DDX23. You can find most of the proteins on our site.

Function Related Protein
ATP bindingADRBK1;PIP5KL1;EPHA1;HSPH1;MARK3;HYOU1;SNRNP200;KIF3A;DAPK3
ATP-dependent RNA helicase activityDDX5;DHX8;EIF4A2;SKIV2L;DDX42;BAT1;DDX39B;DHX9;DHX34
NOT ATP-dependent helicase activity
poly(A) RNA bindingANKRD17;IFIT5;UCHL5;RSL24D1;PRAC;RRP12;NCBP1;PPP1CC;RPUSD3
protein bindingFAM46D;ATOX1;APBB3;TIPRL;NLRP3;MALT1;CD163;NPBWR1;CWC15

DDX23 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX23 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX23.

PRPF4; SNW1; TERF1; WBP4; CD2BP2; RNPS1; SF3A2; USP39; SNRNP40; Prpf8; BNLF1; q7cia4_yerpe; TERF2IP; ssrna_ag; Junb; TOP1

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