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DDX5

  • Official Full Name

    DEAD (Asp-Glu-Ala-Asp) box helicase 5

  • Overview

    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified. [provided by RefSeq, Jul 2008]
  • Synonyms

    DDX5; DEAD (Asp-Glu-Ala-Asp) box helicase 5; p68; HLR1; G17P1; HUMP68; probable ATP-dependent RNA helicase DDX5; DEAD box-5; RNA helicase p68; DEAD box protein 5; ATP-dependent RNA helicase DDX5; DEAD (Asp-Glu-Ala-Asp) box polypeptide 5; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DDX5-464H Recombinant Human DDX5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DDX5-2497H Recombinant Human DDX5 Protein, GST-tagged Wheat Germ GST
Human DDX5-7004HCL Recombinant Human DDX5 293 Cell Lysate HEK293 N/A
Human DDX5-745H Recombinant Human DDX5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DDX5-4592H Recombinant Human DDX5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DDX5-745H-B Recombinant Human DDX5 Protein Pre-coupled Magnetic Beads HEK293
Human DDX5-2809H Recombinant Human DDX5 protein, His&Myc-tagged E.coli His&Myc 1-614aa
Human DDX5-2646HF Recombinant Full Length Human DDX5 Protein, GST-tagged In Vitro Cell Free System GST 614 amino acids
Human DDX5-49HFL Active Recombinant Full Length Human DDX5 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Ddx5-2510M Recombinant Mouse Ddx5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Cynomolgus Monkey DDX5-458C Recombinant Cynomolgus DDX5 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey DDX5-204C Recombinant Cynomolgus Monkey DDX5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey DDX5-204C-B Recombinant Cynomolgus Monkey DDX5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DDX5-1221R Recombinant Rhesus monkey DDX5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DDX5-1046R Recombinant Rhesus Macaque DDX5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DDX5-1046R-B Recombinant Rhesus Macaque DDX5 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DDX5-11891Z Recombinant Zebrafish DDX5 Mammalian Cell His
Chicken DDX5-6390C Recombinant Chicken DDX5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DDX5 Related Articles

DDX5 involved in several pathways and played different roles in them. We selected most pathways DDX5 participated on our site, such as Direct p53 effectors, Proteoglycans in cancer, Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Direct p53 effectorsPCBP4;GDF15;GADD45A;PLK3;HIC1;CEBPZ;DGCR8;FDXR;BNIP3L
Proteoglycans in cancerTFAP4;CAMK2G;FZD7;FLNC;LUM;HSPB2;AKT2;WNT11;ITGAV
SpliceosomeHNRNPUB;SF3A1;LSM5;HSPA1L;SF3B2;SRSF1A;U2AF2B;AQR;DHX8
Transcriptional misregulation in cancerHOXA9;MMP3;PPARG;PAX7;WNT16;PROM1;HOXA11;TLX3;HIST2H3C1

DDX5 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, RNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX5 itself. We selected most functions DDX5 had, and list some proteins which have the same functions with DDX5. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTARS2;UBE2NA;PCCA;RFC4;MYO1H;LATS1;QRSL1;UBE2Q1;GRK7A
ATP-dependent RNA helicase activityDDX3;DDX5;DQX1;DDX53;DHX9;DDX24;DDX25;DDX39B;FAM120B
RNA helicase activityCTU1;UAP1L1;CHST13;DDX24;SKIV2L2;DDX5;DHX16;PRIM2;DHX9
androgen receptor bindingDAXX;GRIP1;NRIP1;TRIM68;NCOA3;RNF6;BRCA1;SMARCA4;KDM1A
calcium-dependent protein bindingTNNC1;RAC3;CASQ2;CPNE3;ANXA2;DMBT1;MMP13;TNNT3;S100PBP
calmodulin bindingSLC8A2;TJP1;RIT2;KCNN2;RRAD;ITPKC;PHKB;REM1;CAMK2B
enzyme bindingCPSF1;UGT1A6;CCDC99;NPC2;USP22;HSPA8;HIST1H2AL;MLEC;CD4
estrogen receptor bindingPRMT2;MED1;XBP1;MMS19;STRN;PPARGC1A;NKX3-1;NCOA1;PCNA
poly(A) RNA bindingMBNL3;NDUFV3;AGO2;DSP;FAM98A;SRRT;NSBP1;ZNF346;SNRPD2
pre-mRNA bindingRBM22;SRSF2;DDX5;TARBP2;PTBP1
protein bindingUSP20;GPATCH4;DVL1;LOC780933;ATP6V0C;EPHA4;TUBA1B;CCDC50;SMARCC1
transcription coactivator activitySRA1;CEBPA;TADA1;TRIM32;MNT;PPARGC1A;MYCBP;NCOA3;TAF5L

DDX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX5.

ESR1; p27958-pro_0000037577

Nishida, Y; Aida, K; et al. Antibody-Validated Proteins in Inflamed Islets of Fulminant Type 1 Diabetes Profiled by Laser-Capture Microdissection Followed by Mass Spectrometry. PLOS ONE 9:-(2014).
Geissler, V; Altmeyer, S; et al. The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA. NUCLEIC ACIDS RESEARCH 41:7875-7888(2013).
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