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DDX58

  • Official Full Name

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

  • Overview

    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. [provided by RefSeq, Jul 2008]
  • Synonyms

    DDX58; DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; RIGI; RIG-I; RLR-1; probable ATP-dependent RNA helicase DDX58; RIG-1; RNA helicase RIG-I; DEAD box protein 58; RIG-I-like receptor 1; retinoic acid inducible gene I; retinoic acid-inducible gene 1 protein; retinoic acid-inducible gene I protein; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DDX58-7087H Recombinant Human DDX58 protein, His-tagged E.coli His Asp550~Phe776
Human DDX58-10H Recombinant Human DDX58, GST-tagged Wheat Germ GST
Human DDX58-11H Recombinant Human DDX58, MYC/DDK-tagged HEK293 Myc/DDK
Human DDX58-7000HCL Recombinant Human DDX58 293 Cell Lysate HEK293 N/A
Human DDX58-6897HF Recombinant Full Length Human DDX58 Protein, GST-tagged In Vitro Cell Free System GST 925 amino acids
Human DDX58-452H Recombinant Human DDX58 Protein (1-430 aa), His-tagged E.coli His 1-430 aa
Human DDX58-2702H Recombinant Human DDX58 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DDX58-2069H Recombinant Human DDX58 Protein (Ile725-Lys925), N-His tagged E.coli N-His Ile725-Lys925
Human DDX58-1275HFL Recombinant Full Length Human DDX58, Flag-tagged Mamanlian cells Flag
Human DDX58-2070H Recombinant Human DDX58 Protein () E.coli Tag Free
Mouse Ddx58-7088M Recombinant Mouse Ddx58 protein, His-tagged E.coli His Met1~Gln211
Mouse Ddx58-2513M Recombinant Mouse Ddx58 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque DDX58-1223R Recombinant Rhesus monkey DDX58 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DDX58-1048R-B Recombinant Rhesus Macaque DDX58 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DDX58-1048R Recombinant Rhesus Macaque DDX58 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DDX58 Related Articles

DDX58 involved in several pathways and played different roles in them. We selected most pathways DDX58 participated on our site, such as NF-kappa B signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX58 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayNFKB2;BCL2A1;GM13304;LTA;PIAS4;PLCG2;NFKB1;ATM;IKBKB
RIG-I-like receptor signaling pathwayISG15;ATG12;IFNA2;DDX58;IL12B;TANK;MAPK9;IFNA21;TBKBP1
Cytosolic DNA-sensing pathwayRIPK1;TBK1;MAVS;CCL5;CXCL10;POLR1D;IL18;POLR2F;IFNA6
Hepatitis CIRF1;MAPK10;IRF7;NFKB1;SCARB1;BAD;PIAS1;IL-8;IFNA1
Hepatitis BPRKCB;MAVS;TLR2;Ifna15;CREB3L1;FAS;ATP6AP1;CYCS;CXCL8
MeaslesCD209C;EIF2AK3;TYK2;PIK3R2;CCNE2;PIK3CG;TBK1;Cd209g;IL1B
Influenza AIFNA5;TNFSF10;MAPK10;HSPA1B;TMPRSS4;NFKB1;MAP2K2;MAPK1;CASP9
Herpes simplex infectionTAP1;IFNPHI1;CD74A;TAP2;HLA-DOB;IFNA6;CYCS;HCFC1;BLB2
Epstein-Barr virus infectionTBPL2;PSMD1;RIPK1;HLA-DRA;PSMD7;POLR3D;RAN;MAP2K7;MAPK12

DDX58 has several biochemical functions, for example, ATP binding, double-stranded DNA binding, double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX58 itself. We selected most functions DDX58 had, and list some proteins which have the same functions with DDX58. You can find most of the proteins on our site.

Function Related Protein
ATP bindingNLRP4C;CAMKK1A;UBE2E2;MAP3K15;MKNK2;SMG1;CSNK1G2;ERCC6;MAPK14B
double-stranded DNA bindingMEN1;HNRPDL;PRKDC;HNRNPDL;XRCC2;TP53;NKX2-8;NEIL3;TP73
double-stranded RNA bindingILF2;OAS1;LRRFIP1;MBNL1;MYH4;HSPD1;SUPV3L1;LSM14A;DROSHA
helicase activityWRN;MOV10;DHX57;RAD54L;ATRX;HELZ2;DDX52;DDX19B;HELZ
identical protein bindingCAV1;DIAP1;IAPP;MRI1;CD247;L3MBTL1;TGFB3;ADIPOR2;SHARPIN
protein bindingIFT88;XPO6;SETX;COL1A1;MYOM1;HTN1;GTF2I;DEDD;RAB11FIP3
single-stranded RNA bindingLUZP4;STRBP;CNBP;AGO3;NXF1;EIF2C3;HNRNPA1;HNRNPF;POLR2G
zinc ion bindingMLLT10;ZNF385D;TRIML1;RNF141;ZNF330;LHX3;NR1D4A;ZCCHC6;PHF13

DDX58 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX58 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX58.

MAVS; ZC3HAV1; TRIM25

Ovsyannikova, IG; Salk, HM; et al. Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines. IMMUNOGENETICS 66:663-669(2014).
Enevold, C; Kjaer, L; et al. Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes. RHEUMATOLOGY INTERNATIONAL 34:1401-1408(2014).
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