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DDX6

  • Official Full Name

    DEAD (Asp-Glu-Ala-Asp) box helicase 6

  • Overview

    The lymphoma-associated Rck/p54 gene product is a member of the DEAD box protein/RNA helicase family which has a variety of functions including translation initiation, pre-mRNA splicing, and ribosome assembly. Overexpression of human Rck in a guinea pig c
  • Synonyms

    DDX6; DEAD (Asp-Glu-Ala-Asp) box helicase 6; DEAD (Asp Glu Ala Asp) box polypeptide 6 , DEAD/H (Asp Glu Ala Asp/His) box polypeptide 6 (RNA helicase, 54kD) , HLR2; probable ATP-dependent RNA helicase DDX6; RCK; DEAD box-6; oncogene RCK; DEAD box protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DDX6-28328TH Recombinant Human DDX6 protein, GST-tagged Wheat Germ GST
Human DDX6-45H Recombinant Human DDX6 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DDX6-6998HCL Recombinant Human DDX6 293 Cell Lysate HEK293 N/A
Human DDX6-6899HF Recombinant Full Length Human DDX6 Protein, GST-tagged In Vitro Cell Free System GST 483 amino acids
Mouse DDX6-4433M Recombinant Mouse DDX6 Protein Mammalian Cell His
Mouse Ddx6-2515M Recombinant Mouse Ddx6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DDX6-2280M Recombinant Mouse DDX6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DDX6-2280M-B Recombinant Mouse DDX6 Protein Pre-coupled Magnetic Beads HEK293
Chicken DDX6-5430C Recombinant Chicken DDX6 Mammalian Cell His
Chicken DDX6-1464C Recombinant Chicken DDX6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DDX6 Related Articles

DDX6 involved in several pathways and played different roles in them. We selected most pathways DDX6 participated on our site, such as Deadenylation-dependent mRNA decay, Gene Expression, RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Deadenylation-dependent mRNA decayEIF4A2;EIF4EB;TNKS1BP1;EIF4G1;EIF4A1;DDX6;D1BWG0212E;DCP1B;EIF4B
Gene ExpressionCLP1;MANEA;GTF3AB;RARG;MBD3;ZNF200;SETB;ALKBH8;NR1I3
RNA degradationPFKM;CNOT10;PABPC1;PAN3;PARN;LSM6;DCPS;LSM7;EXOSC5
mRNA decay by 5 to 3 exoribonucleaseDDX6;LSM6;DCP1B

DDX6 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, RNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX6 itself. We selected most functions DDX6 had, and list some proteins which have the same functions with DDX6. You can find most of the proteins on our site.

Function Related Protein
ATP bindingGSK3AA;BMPR1BB;DDX17;ABCD2;SETX;HLCS;LRRK1;FIGNL1;GUCY2E
ATP-dependent RNA helicase activityDDX39AA;DHX32;DHX16;DDX39A;EIF4A2;DHX9;DDX55;DDX19A;DDX43
RNA helicase activityDHX15;SKIV2L2;FAM120B;DDX24;DDX5;DDX17;CTU1;CHST13;CCDC111
helicase activityTDRD12;DHX57;DNA2;HELZ;HELLS;CHD9;CHD1L;DDX6;DDX52
poly(A) RNA bindingMRPS35;RRP7A;PEF1;SUB1;C11orf68;KCTD12;ARCN1;DYNC1H1;TMSB4X
protein bindingArid4b;TERF1;SERPINF1;SOX13;PLD2;PIGK;PLLP;ZBTB8A;PIBF1
protein domain specific bindingCACNB2;TFDP2;CRB3;CALM1;LIN7C;HGS;HIST1H4F;SP100;OCLN

DDX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX6.

DCP1A; EDC3; YBX1; TRIM37

Johanneson, B; Chen, D; et al. Systematic validation of hypothesis-driven candidate genes for cervical cancer in a genome-wide association study. CARCINOGENESIS 35:2084-2088(2014).
Kawahara, C; Yokota, S; et al. DDX6 localizes to nuage structures and the annulus of mammalian spermatogenic cells. HISTOCHEMISTRY AND CELL BIOLOGY 141:111-121(2014).
  • Q&As
  • Reviews

Q&As (5)

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Can targeting DDX6 be a therapeutic strategy for cancer treatment? 12/13/2022

There is emerging interest in developing therapies that target DDX6 to modulate its activity, potentially impacting cancer cell growth.

Does DDX6 have a role in antiviral defense mechanisms? 06/25/2022

Yes, DDX6 has been implicated in antiviral responses, influencing the replication of certain viruses.

How does DDX6 influence RNA granules in cells? 12/01/2016

DDX6 is a component of RNA granules and is involved in their assembly, influencing mRNA storage and translation repression.

How is DDX6 implicated in cancer? 07/23/2016

DDX6 dysregulation has been observed in various cancers, suggesting its involvement in tumorigenesis and progression.

Are there clinical trials exploring DDX6 as a therapeutic target? 03/13/2016

Some preclinical studies suggest the therapeutic potential of targeting DDX6, but clinical trials are still in the early stages.

Customer Reviews (3)

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Reviews
01/25/2023

    Whether it's troubleshooting experimental issues, providing guidance on experimental design, or answering any inquiries related to the DDX6 protein, the manufacturer is committed to helping researchers overcome challenges and achieve their scientific goals.

    09/09/2019

      The manufacturer also values customer satisfaction and strives to maintain a strong relationship with researchers.

      01/13/2016

        They actively seek feedback and incorporate it into their product development process, continuously improving the quality and performance of the DDX6 protein.

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