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DEDD2

  • Official Full Name

    death effector domain containing 2

  • Overview

    Death effector domain-containing protein is a protein that in humans is encoded by the DEDD gene. This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    DEDD2; death effector domain containing 2; FLAME-3; DNA-binding death effector domain-containing protein 2; DED-containing protein FLAME-3; FADD-like anti-apoptotic molecule 3; death effector domain-containing DNA binding protein 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DEDD2-2515H Recombinant Human DEDD2 Protein, GST-tagged Wheat Germ GST
Human DEDD2-6994HCL Recombinant Human DEDD2 293 Cell Lysate HEK293 N/A
Human DEDD2-2418HF Recombinant Full Length Human DEDD2 Protein, GST-tagged In Vitro Cell Free System GST 185 amino acids
Mouse DEDD2-4441M Recombinant Mouse DEDD2 Protein Mammalian Cell His
Mouse DEDD2-2283M-B Recombinant Mouse DEDD2 Protein Pre-coupled Magnetic Beads HEK293
Mouse DEDD2-2283M Recombinant Mouse DEDD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DEDD2 involved in several pathways and played different roles in them. We selected most pathways DEDD2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DEDD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

DEDD2 has several biochemical functions, for example, DNA binding, protein binding, receptor signaling complex scaffold activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DEDD2 itself. We selected most functions DEDD2 had, and list some proteins which have the same functions with DEDD2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingPOU3F2A;ZBTB3;INSM1A;HNF1BB;ZSCAN1;ZNF484;LHX2B;HIST1H2BG;NR6A1
protein bindingPOLDIP3;UBXN4;GNS;ROPN1L;MAP3K5;APLP1;CACNA2D1A;FBXL3;STAP1
receptor signaling complex scaffold activityRGS14;SPAG9;NCK2;LDLRAP1;GRIP1;CD3E;DEDD2;AXIN1;LRRK2

DEDD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEDD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DEDD2.

CDK6; ATG16L1

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