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DEF6

  • Official Full Name

    differentially expressed in FDCP 6 homolog (mouse)

  • Overview

    DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly;expressed in B and T cells (Gupta et al., 2003 (PubMed 12923183)).
  • Synonyms

    DEF6; differentially expressed in FDCP 6 homolog (mouse); differentially expressed in FDCP (mouse homolog) 6; differentially expressed in FDCP 6 homolog; IBP; SLAT; SWAP 70 like adaptor protein of T cells; SWAP70L; DEF-6; IRF4-binding protein; SWAP-70-lik;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DEF6-11923H Recombinant Human DEF6, GST-tagged E.coli GST N-term-336a.a.
Human DEF6-491H Recombinant Human DEF6 Protein, His-tagged E.coli His
Human DEF6-460H Recombinant Human DEF6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DEF6-2516H Recombinant Human DEF6 Protein, GST-tagged Wheat Germ GST
Human DEF6-6993HCL Recombinant Human DEF6 293 Cell Lysate HEK293 N/A
Human DEF6-4588H Recombinant Human DEF6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DEF6-2421HF Recombinant Full Length Human DEF6 Protein, GST-tagged In Vitro Cell Free System GST 336 amino acids
Mouse DEF6-4442M Recombinant Mouse DEF6 Protein Mammalian Cell His
Mouse DEF6-2284M Recombinant Mouse DEF6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DEF6-2284M-B Recombinant Mouse DEF6 Protein Pre-coupled Magnetic Beads HEK293
Mouse Def6-2517M Recombinant Mouse Def6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DEF6 involved in several pathways and played different roles in them. We selected most pathways DEF6 participated on our site, such as Regulation of RAC1 activity, Regulation of RhoA activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with DEF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Regulation of RAC1 activityABR;EPS8;ARHGAP9;SPATA13;DEF6;ARHGAP17;CHN2;PREX2;ARHGAP1
Regulation of RhoA activityARHGAP9;AKAP13;ARHGEF18;NET1;DEF6;OBSCN;ECT2;MCF2L;ARHGEF10L

DEF6 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DEF6 itself. We selected most functions DEF6 had, and list some proteins which have the same functions with DEF6. You can find most of the proteins on our site.

Function Related Protein
protein bindingNOS2;FAM90A1;SOX4;DNAJB6;POLE4;THOC2;TRIM35;CABP1;ITGA2B

DEF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DEF6.

PTK2; PLSCR1; TCF4; CDC42EP1; HOMEZ; PBXIP1; EIF4ENIF1

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