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DEFA5

  • Official Full Name

    defensin, alpha 5, Paneth cell-specific

  • Overview

    Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum.
  • Synonyms

    DEFA5; defensin, alpha 5, Paneth cell-specific; DEF5; defensin-5; HD 5; defensin 5; defensin, alpha 5, preproprotein; HD-5; MGC129728;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DEFA5-450H Recombinant Human DEFA5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DEFA5-11927H Recombinant Human DEFA5, GST-tagged E.coli GST 24-94a.a.
Human DEFA5-1963H Recombinant Human DEFA5 protein, His-tagged E.coli His Glu20~Arg94
Human DEFA5-2519H Recombinant Human DEFA5 Protein, GST-tagged Wheat Germ GST
Human DEFA5-463HCL Recombinant Human DEFA5 cell lysate N/A
Human DEFA5-1403H Recombinant Human DEFA5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DEFA5-746H Recombinant Human DEFA5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DEFA5-1943H Recombinant Human DEFA5 Protein (Glu20-Arg94), His tagged E.coli His Glu20-Arg94
Human DEFA5-2427HF Recombinant Full Length Human DEFA5 Protein, GST-tagged In Vitro Cell Free System GST 94 amino acids
Human DEFA5-551HFL Recombinant Full Length Human DEFA5 Protein, C-Flag-tagged Mammalian cells Flag
Human DEFA5-746H-B Recombinant Human DEFA5 Protein Pre-coupled Magnetic Beads HEK293
Mouse Defa5-3355M Recombinant Mouse Defa5, His-tagged E.Coli or Yeast His 93
Mouse Defa5-1328M Recombinant Mouse Defa5 Protein, His&GST-tagged E.coli N-His&GST Asp20-Ser93
Mouse DEFA5-1955M Recombinant Mouse DEFA5 Protein (59-93 aa), GST-tagged E.coli GST 59-93 aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DEFA5 involved in several pathways and played different roles in them. We selected most pathways DEFA5 participated on our site, such as Alpha-defensins, Defensins, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with DEFA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alpha-defensinsDEFA3;DEFA5;ART1;DEFA1;DEFA6
DefensinsDEFA6;DEFA3;DEFB125;DEFB119;DEFB4B;DEFB4A;DEFB1;DEFB106A;DEFB129
Immune SystemTNFSF13B;FBXO17;TRIM69;SEC24A;KPNA5;TLR10;CD160;RNF216;WSB1
Innate Immune SystemTAX1BP1B;PPAPDC1B;BTR18;TAX1BP1;BTR09;DEFB106A;POLR3F;TXNIPB;NLRC5

DEFA5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DEFA5 itself. We selected most functions DEFA5 had, and list some proteins which have the same functions with DEFA5. You can find most of the proteins on our site.

Function Related Protein

DEFA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEFA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DEFA5.

DTX1

  • Q&As
  • Reviews

Q&As (7)

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Is DEFA5 linked to any diseases? 03/31/2022

Altered DEFA5 expression has been associated with various gastrointestinal disorders, including inflammatory bowel diseases (IBD).

Are there specific diseases where DEFA5 is implicated? 06/25/2021

DEFA5 has been implicated in conditions such as inflammatory bowel diseases (IBD) and other gastrointestinal disorders.

What is the significance of DEFA5? 09/26/2020

DEFA5, known as Defensin Alpha 5, is a crucial member of the defensin family, functioning as an antimicrobial peptide.

What role does DEFA5 play in innate immunity? 12/22/2019

DEFA5 contributes to innate immunity by directly targeting and inhibiting the growth of pathogenic microorganisms in the gut.

How does DEFA5 function in host defense? 06/15/2019

DEFA5 acts as an antimicrobial peptide, defending the gut against bacterial infections and helping maintain a balanced gut microbiota.

Can DEFA5 be a potential therapeutic target? 10/11/2018

DEFA5 is being investigated as a potential therapeutic target for conditions involving gut infections and imbalances in the gut microbiota.

What is the primary tissue of expression for DEFA5? 01/18/2018

DEFA5 is primarily expressed in Paneth cells located in the small intestine, contributing to innate immune defense in the gut.

Customer Reviews (3)

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Reviews
08/16/2019

    The product's established reputation in the scientific community provided assurance of its reliability.

    07/07/2019

      The product's innovative features hinted at its potential for advancing our research in uncharted territories.

      12/20/2016

        We were excited about the product's role in driving future discoveries in our field of study.

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